PGS Publication: PGP000306

Publication Information (EuropePMC)
Title Common genetic variants do not predict recurrent events in coronary heart disease patients.
PubMed ID 35264114(Europe PMC)
doi 10.1186/s12872-022-02520-0
Publication Date March 9, 2022
Journal BMC Cardiovasc Disord
Author(s) Thompson PL, Hui J, Beilby J, Palmer LJ, Watts GF, West MJ, Kirby A, Marschner S, Simes RJ, Sullivan DR, White HD, Stewart R, Tonkin AM.
Released in PGS Catalog: April 13, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000010
(GRS27)
 PGP000003 |
Mega JL et al. Lancet (2015)
 Coronary heart disease coronary artery disease 27
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000010/ScoringFiles/PGS000010.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012951 PGS000010
(GRS27)
 PSS009630|
European Ancestry|
4,932 individuals
 PGP000306 |
Thompson PL et al. BMC Cardiovasc Disord (2022)
|Ext.		 Reported Trait: Reccurent cardiovascular event (coronary heart disease death, non-fatal myocardial infraction, unstable angina pectoris, coronary artery bypass graft and Percutaneous coronary intervention) — C-index: 0.7 NRI (GRS-added vs. baseline model): 0.097 Hypertension, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, diabetes, sex, age, current smoking Basline model C-index = 0.69

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009630 Entry to the trial had required a history of acute coronary syndrome 3–36 months previously, and patients were in the trial for a mean of 36 months. 1558 deaths, 898 cardiovascular deaths, 727 CHD deaths and 375 cancer deaths Mean = 36.0 months
[
  • 898 cases
  • , 4,034 controls
]
,
84.0 % Male samples
 Mean = 60.2 years
Sd = 8.41 years		 European — NR LIPID (Long-term Intervention with Pravastatin in Ischaemic Disease) randomised controlled trial