| Publication Information (EuropePMC) | |
| Title | Associations of polygenic risk for attention-deficit/hyperactivity disorder with general and specific dimensions of childhood psychological problems and facets of impulsivity. |
| PubMed ID | 35752070(Europe PMC) |
| doi | 10.1016/j.jpsychires.2022.06.019 |
| Publication Date | June 14, 2022 |
| Journal | J Psychiatr Res |
| Author(s) | Lahey BB, Tong L, Pierce B, Hedeker D, Berman MG, Cardenas-Iniguez C, Moore TM, Applegate B, Tiemeier H, Kaczkurkin AN. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS002746 (PRS_ADHD) |
PGP000358 | Lahey BB et al. J Psychiatr Res (2022) |
Attention-deficit hyperactivity disorder | attention deficit hyperactivity disorder | 513,659 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002746/ScoringFiles/PGS002746.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM014920 | PGS002746 (PRS_ADHD) |
PSS009931| European Ancestry| 4,483 individuals |
PGP000358 | Lahey BB et al. J Psychiatr Res (2022) |
Reported Trait: Specific internalizing (at baseline) | β: -0.06 (0.02) | — | — | — | — |
| PPM014921 | PGS002746 (PRS_ADHD) |
PSS009931| European Ancestry| 4,483 individuals |
PGP000358 | Lahey BB et al. J Psychiatr Res (2022) |
Reported Trait: Specific conduct problem (1-year follow-up) | β: 0.09 (0.02) | — | — | — | — |
| PPM014922 | PGS002746 (PRS_ADHD) |
PSS009931| European Ancestry| 4,483 individuals |
PGP000358 | Lahey BB et al. J Psychiatr Res (2022) |
Reported Trait: Specific ADHD (1-year follow-up) | β: 0.11 (0.03) | — | — | — | — |
| PPM014924 | PGS002746 (PRS_ADHD) |
PSS009931| European Ancestry| 4,483 individuals |
PGP000358 | Lahey BB et al. J Psychiatr Res (2022) |
Reported Trait: UPPS Impulsive Behavior Scale (Positive urgency) | β: 0.046 (0.016) | — | — | Age, sex, and the first 10 principal components of population structure | — |
| PPM014925 | PGS002746 (PRS_ADHD) |
PSS009931| European Ancestry| 4,483 individuals |
PGP000358 | Lahey BB et al. J Psychiatr Res (2022) |
Reported Trait: Latent executive functioning | β: -0.042 | — | — | Age, sex, and the first 10 principal components of population structure | — |
| PPM014919 | PGS002746 (PRS_ADHD) |
PSS009931| European Ancestry| 4,483 individuals |
PGP000358 | Lahey BB et al. J Psychiatr Res (2022) |
Reported Trait: General factor of psychological problems (1-year follow-up) | β: 0.07 (0.02) | — | — | — | — |
| PPM014923 | PGS002746 (PRS_ADHD) |
PSS009931| European Ancestry| 4,483 individuals |
PGP000358 | Lahey BB et al. J Psychiatr Res (2022) |
Reported Trait: UPPS Impulsive Behavior Scale (Low perseverance) | β: 0.043 (0.017) | — | — | Age, sex, and the first 10 principal components of population structure | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS009931 | — | 4,483 individuals, 53.2 % Male samples |
Mean = 118.94 months Sd = 7.48 months |
European | — | NR | ABCD |