Trait: attention deficit hyperactivity disorder

Experimental Factor Ontology (EFO) Information
Identifier EFO_0003888
Description A disorder characterized by a marked pattern of inattention and/or hyperactivity-impulsivity that is inconsistent with developmental level and clearly interferes with functioning in at least two settings (e.g. at home and at school). When present, the symptoms of hyperactivity are most often present before the age of 7 years. There are three recognized presentations or subtypes from most to least common: combined type, inattentive/distractible type, hyperactive/impulsive type. [NCIT: C97160]
Trait category
Neurological disorder
Synonyms 22 synonyms
  • ADDH
  • ADHD
  • ATTENTION DEFICIT DIS
  • ATTENTION DEFICIT DIS WITH HYPERACTIVITY
  • ATTENTION DEFICIT HYPERACTIVITY DIS
  • Attention Deficit Disorder
  • Attention Deficit Disorder with Hyperactivity
  • Attention Deficit Disorders
  • Attention Deficit Disorders with Hyperactivity
  • Attention Deficit Hyperactivity Disorders
  • Brain Dysfunction, Minimal
  • Deficit Disorder, Attention
  • Deficit Disorders, Attention
  • Disorder, Attention Deficit
  • Disorders, Attention Deficit
  • Dysfunction, Minimal Brain
  • Hyperkinetic Syndrome
  • Minimal Brain Dysfunction
  • Syndromes, Hyperkinetic
  • attention deficit hyperactivity disorder
  • attention deficit-hyperactivity disorder
  • attention deficit/hyperactivity disorder
Mapped terms 14 mapped terms
  • DOID:1094
  • ICD9:314.01
  • MEDGEN:220387
  • MONDO:0007743
  • MeSH:D001289
  • MedDRA:10003735
  • MedDRA:10003736
  • MedDRA:10083622
  • NCIT:C97160
  • NCIt:C97160
  • OMIM:143465
  • OMIM:613003
  • SNOMEDCT:406506008
  • UMLS:C1263846

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002746
(PRS_ADHD)
 PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
 Attention-deficit hyperactivity disorder attention deficit hyperactivity disorder 513,659
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002746/ScoringFiles/PGS002746.txt.gz
PGS003753
(PRS35445_ADHD)
 PGP000473 |
Sato JR et al. Genes Brain Behav (2023)
 Attention deficit hyperactivity disorder attention deficit hyperactivity disorder 35,445
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003753/ScoringFiles/PGS003753.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014920 PGS002746
(PRS_ADHD)
 PSS009931|
European Ancestry|
4,483 individuals
 PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
 Reported Trait: Specific internalizing (at baseline) β: -0.06 (0.02) — — — —
PPM014921 PGS002746
(PRS_ADHD)
 PSS009931|
European Ancestry|
4,483 individuals
 PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
 Reported Trait: Specific conduct problem (1-year follow-up) β: 0.09 (0.02) — — — —
PPM014922 PGS002746
(PRS_ADHD)
 PSS009931|
European Ancestry|
4,483 individuals
 PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
 Reported Trait: Specific ADHD (1-year follow-up) β: 0.11 (0.03) — — — —
PPM014924 PGS002746
(PRS_ADHD)
 PSS009931|
European Ancestry|
4,483 individuals
 PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
 Reported Trait: UPPS Impulsive Behavior Scale (Positive urgency) β: 0.046 (0.016) — — Age, sex, and the first 10 principal components of population structure —
PPM014925 PGS002746
(PRS_ADHD)
 PSS009931|
European Ancestry|
4,483 individuals
 PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
 Reported Trait: Latent executive functioning β: -0.042 — — Age, sex, and the first 10 principal components of population structure —
PPM014919 PGS002746
(PRS_ADHD)
 PSS009931|
European Ancestry|
4,483 individuals
 PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
 Reported Trait: General factor of psychological problems (1-year follow-up) β: 0.07 (0.02) — — — —
PPM014923 PGS002746
(PRS_ADHD)
 PSS009931|
European Ancestry|
4,483 individuals
 PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
 Reported Trait: UPPS Impulsive Behavior Scale (Low perseverance) β: 0.043 (0.017) — — Age, sex, and the first 10 principal components of population structure —
PPM018515 PGS003753
(PRS35445_ADHD)
 PSS011004|
Hispanic or Latin American Ancestry|
237 individuals
 PGP000473 |
Sato JR et al. Genes Brain Behav (2023)
 Reported Trait: ADHD scores from DAWBA questionnaire β: 1.35e-06 — — — —
PPM018516 PGS003753
(PRS35445_ADHD)
 PSS011004|
Hispanic or Latin American Ancestry|
237 individuals
 PGP000473 |
Sato JR et al. Genes Brain Behav (2023)
 Reported Trait: Segregation of brain functional network (cingulo-opercular network) β: -3e-05 (1.28e-05) — — — —
PPM018517 PGS003753
(PRS35445_ADHD)
 PSS011004|
Hispanic or Latin American Ancestry|
237 individuals
 PGP000473 |
Sato JR et al. Genes Brain Behav (2023)
 Reported Trait: Segregation of brain functional network (default mode) β: 2e-05 (1.05e-05) — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011004 — — 237 individuals,
51.0 % Male samples
 — Hispanic or Latin American
(Brazilian)		 — NR BHRCS
PSS009931 — 4,483 individuals,
53.2 % Male samples
 Mean = 118.94 months
Sd = 7.48 months		 European — NR ABCD