PGS Publication: PGP000473

Publication Information (EuropePMC)
Title Polygenic risk score for attention-deficit/hyperactivity disorder and brain functional networks segregation in a community-based sample.
PubMed ID 36811275(Europe PMC)
doi 10.1111/gbb.12838
Publication Date Feb. 21, 2023
Journal Genes Brain Behav
Author(s) Sato JR, Biazoli CE, Bueno APA, Caye A, Pan PM, Santoro M, Honorato-Mauer J, Salum GA, Hoexter MQ, Bressan RA, Jackowski AP, Miguel EC, Belangero S, Rohde LA.
Released in PGS Catalog: June 22, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003753
(PRS35445_ADHD)
 PGP000473 |
Sato JR et al. Genes Brain Behav (2023)
 Attention deficit hyperactivity disorder attention deficit hyperactivity disorder 35,445
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003753/ScoringFiles/PGS003753.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018515 PGS003753
(PRS35445_ADHD)
 PSS011004|
Hispanic or Latin American Ancestry|
237 individuals
 PGP000473 |
Sato JR et al. Genes Brain Behav (2023)
 Reported Trait: ADHD scores from DAWBA questionnaire β: 1.35e-06 — — — —
PPM018516 PGS003753
(PRS35445_ADHD)
 PSS011004|
Hispanic or Latin American Ancestry|
237 individuals
 PGP000473 |
Sato JR et al. Genes Brain Behav (2023)
 Reported Trait: Segregation of brain functional network (cingulo-opercular network) β: -3e-05 (1.28e-05) — — — —
PPM018517 PGS003753
(PRS35445_ADHD)
 PSS011004|
Hispanic or Latin American Ancestry|
237 individuals
 PGP000473 |
Sato JR et al. Genes Brain Behav (2023)
 Reported Trait: Segregation of brain functional network (default mode) β: 2e-05 (1.05e-05) — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011004 — — 237 individuals,
51.0 % Male samples
 — Hispanic or Latin American
(Brazilian)		 — NR BHRCS