PGS Publication: PGP000363

Publication Information (EuropePMC)
Title Genetic risk score enhances the risk prediction of severe obesity in adult survivors of childhood cancer.
PubMed ID 35879615(Europe PMC)
doi 10.1038/s41591-022-01902-3
Publication Date July 25, 2022
Journal Nat Med
Author(s) Sapkota Y, Qiu W, Dixon SB, Wilson CL, Wang Z, Zhang J, Leisenring W, Chow EJ, Bhatia S, Armstrong G... T, Robison LL, Hudson MM, Delaney A, Yasui Y.Show more
Released in PGS Catalog: Sept. 8, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS002751
(GRSrare)
PGP000363 |
Sapkota Y et al. Nat Med (2022)
Body mass index (BMI)body mass index14
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002751/ScoringFiles/PGS002751.txt.gz
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External PGS Evaluated By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000027
(GPS_BMI)
PGP000017 |
Khera AV et al. Cell (2019)
Body mass index (BMI)body mass index2,100,302
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000027/ScoringFiles/PGS000027.txt.gz - Check Terms/Licenses
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM014943PGS002751
(GRSrare)
PSS009938|
European Ancestry|
6,064 individuals
PGP000363 |
Sapkota Y et al. Nat Med (2022)
Reported Trait: Overweight——Odds Ratio (OR, 10th vs. 1st decile): 1.78 [1.14, 2.79]Cubic splines (five knots at 19.8, 24.0, 28.9, 34.9 and 46.9 years) of age at body mass index assess... ment, 10 genetic PCsShow more—
PPM014944PGS002751
(GRSrare)
PSS009938|
European Ancestry|
6,064 individuals
PGP000363 |
Sapkota Y et al. Nat Med (2022)
Reported Trait: Obesity——Odds Ratio (OR, 10th vs. 1st decile): 1.37 [0.66, 2.88]Cubic splines (five knots at 19.8, 24.0, 28.9, 34.9 and 46.9 years) of age at body mass index assess... ment, 10 genetic PCsShow more—
PPM014945PGS000027
(GPS_BMI)
PSS009938|
European Ancestry|
6,064 individuals
PGP000363 |
Sapkota Y et al. Nat Med (2022)
|Ext.		Reported Trait: Overweight——Odds Ratio (OR, 10th vs. 1st decile): 2.74 [1.64, 4.57]Cubic splines (five knots at 19.8, 24.0, 28.9, 34.9 and 46.9 years) of age at body mass index assess... ment, 10 genetic PCsShow more—
PPM014946PGS000027
(GPS_BMI)
PSS009938|
European Ancestry|
6,064 individuals
PGP000363 |
Sapkota Y et al. Nat Med (2022)
|Ext.		Reported Trait: Obesity——Odds Ratio (OR, 10th vs. 1st decile): 10.04 [5.92, 17.01]Cubic splines (five knots at 19.8, 24.0, 28.9, 34.9 and 46.9 years) of age at body mass index assess... ment, 10 genetic PCsShow more—
PPM014947PGS000027
(GPS_BMI)
PSS009938|
European Ancestry|
6,064 individuals
PGP000363 |
Sapkota Y et al. Nat Med (2022)
|Ext.		Reported Trait: Severe obesity——Odds Ratio (OR, 10th vs. 1st decile): 53.05 [17.64, 159.54]Cubic splines (five knots at 19.8, 24.0, 28.9, 34.9 and 46.9 years) of age at body mass index assess... ment, 10 genetic PCsShow more—
PPM014948PGS000027
(GPS_BMI)
PSS009937|
African Ancestry|
449 individuals
PGP000363 |
Sapkota Y et al. Nat Med (2022)
|Ext.		Reported Trait: Underweight——Odds Ratio (OR, 10th vs. 1st decile): 0.0 [0.0, 0.37]Cubic splines (five knots at 19.8, 24.0, 28.9, 34.9 and 46.9 years) of age at body mass index assess... ment, 10 genetic PCsShow more—
PPM014949PGS000027
(GPS_BMI)
PSS009937|
African Ancestry|
449 individuals
PGP000363 |
Sapkota Y et al. Nat Med (2022)
|Ext.		Reported Trait: Overweight——Odds Ratio (OR, 10th vs. 1st decile): 3.53 [1.03, 12.09]Cubic splines (five knots at 19.8, 24.0, 28.9, 34.9 and 46.9 years) of age at body mass index assess... ment, 10 genetic PCsShow more—
PPM014950PGS000027
(GPS_BMI)
PSS009937|
African Ancestry|
449 individuals
PGP000363 |
Sapkota Y et al. Nat Med (2022)
|Ext.		Reported Trait: Obesity——Odds Ratio (OR, 10th vs. 1st decile): 5.92 [1.67, 20.96]Cubic splines (five knots at 19.8, 24.0, 28.9, 34.9 and 46.9 years) of age at body mass index assess... ment, 10 genetic PCsShow more—
PPM014951PGS000027
(GPS_BMI)
PSS009937|
African Ancestry|
449 individuals
PGP000363 |
Sapkota Y et al. Nat Med (2022)
|Ext.		Reported Trait: Severe obesity——Odds Ratio (OR, 10th vs. 1st decile): 19.68 [2.87, 135.02]Cubic splines (five knots at 19.8, 24.0, 28.9, 34.9 and 46.9 years) of age at body mass index assess... ment, 10 genetic PCsShow more—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS009937——449 individuals,
48.3 % Male samples
—African American or Afro-Caribbean—NR—
PSS009938——6,064 individuals,
47.9 % Male samples
—European—NR—
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