PGS Publication: PGP000372

Publication Information (EuropePMC)
Title Broad clinical manifestations of polygenic risk for coronary artery disease in the Women's Health Initiative.
PubMed ID 36034645(Europe PMC)
doi 10.1038/s43856-022-00171-y
Publication Date Aug. 25, 2022
Journal Commun Med (Lond)
Author(s) Clarke SL, Parham M, Lankester J, Shadyab AH, Liu S, Kooperberg C, Manson JE, Tcheandjieu C, Assimes TL.
Released in PGS Catalog: Sept. 29, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000018
(metaGRS_CAD)
 PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
 Coronary artery disease coronary artery disease 1,745,179
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000018/ScoringFiles/PGS000018.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015480 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Uterine cancer death HR: 0.68 [0.46, 1.0] — — — —
PPM015451 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Self-reported hypertension OR: 1.2 [1.16, 1.24] — — — —
PPM015478 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Brain cancer death HR: 0.71 [0.52, 0.97] — — — —
PPM015479 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Pneumonia death HR: 1.14 [1.0, 1.3] — — — —
PPM015476 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Cerebrovascular death HR: 1.11 [1.03, 1.2] — — — —
PPM015477 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Dementia death HR: 1.11 [1.02, 1.21] — — — —
PPM015454 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Self-reported family history of myocardial infarction OR: 1.16 [1.13, 1.2] — — — —
PPM015455 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Self-reported family history of stroke OR: 1.07 [1.04, 1.11] — — — —
PPM015456 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Self-reported history of breast cancer OR: 0.81 [0.69, 0.95] — — — —
PPM015457 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Self-reported history of non-melanoma skin cancer OR: 0.93 [0.89, 0.98] — — — —
PPM015458 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Self-reported family history of colon cancer OR: 0.95 [0.91, 0.99] — — — —
PPM015459 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Self-reported history of colonoscopy OR: 0.96 [0.93, 0.99] — — — —
PPM015461 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident PTCA OR: 1.53 [1.43, 1.63] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015462 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident myocardial infarction OR: 1.41 [1.32, 1.5] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015463 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident coronary heart disease OR: 1.31 [1.23, 1.38] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015464 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident CABG OR: 1.53 [1.39, 1.7] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015465 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident all angina OR: 1.38 [1.26, 1.51] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015466 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident ischemic stroke OR: 1.11 [1.04, 1.19] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015467 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident all stroke OR: 1.09 [1.03, 1.16] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015468 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident TIA OR: 1.21 [1.04, 1.41] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015469 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident peripheral artery disease OR: 1.16 [1.01, 1.32] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015470 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident carotid disease OR: 1.14 [1.0, 1.3] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015471 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident any cancer OR: 0.96 [0.93, 0.99] — — Smoking status, alcohol consumption, weekly physical activity, dietary health measured by the alternative healthy eating index, and BMI —
PPM015472 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident lung cancer OR: 0.91 [0.83, 0.99] — — Smoking status, alcohol consumption, weekly physical activity, dietary health measured by the alternative healthy eating index, and BMI —
PPM015473 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident breast cancer OR: 0.96 [0.92, 1.0] — — Smoking status, alcohol consumption, weekly physical activity, dietary health measured by the alternative healthy eating index, and BMI —
PPM015474 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Coronary heart disease death HR: 1.29 [1.16, 1.43] — — — —
PPM015475 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Death of unknown cause HR: 1.28 [1.07, 1.54] — — — —
PPM015452 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Self-reported hypercholesterolemia OR: 1.17 [1.12, 1.23] — — — —
PPM015453 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Self-reported rheumatoid arthritis OR: 1.11 [1.03, 1.19] — — — —
PPM015460 PGS000018
(metaGRS_CAD)
 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident coronary revascularization OR: 1.54 [1.45, 1.63] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009958 — — 21,863 individuals,
0.0 % Male samples
 Mean = 65.3 years European
(Non-Hispanic White)		 — WHI —