PGS Publication: PGP000524

Publication Information (EuropePMC)
Title Secondhand smoke, genetic susceptibility, and incident chronic kidney disease in never smokers: A prospective study of a selected population from the UK Biobank.
PubMed ID 37181462(Europe PMC)
doi 10.18332/tid/162607
Publication Date May 10, 2023
Journal Tob Induc Dis
Author(s) Lan R, Li X, Chen X, Hu J, Luo W, Lv L, Shen Y, Qin Y, Mao L, Ye H, Li Q, Wang Z.
Released in PGS Catalog: Dec. 15, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004224
(GRS241_CKD)
 PGP000524 |
Lan R et al. Tob Induc Dis (2023)
 Chronic kidney disease chronic kidney disease 241
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004224/ScoringFiles/PGS004224.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020162 PGS004224
(GRS241_CKD)
 PSS011300|
Multi-ancestry (including European)|
214,244 individuals
 PGP000524 |
Lan R et al. Tob Induc Dis (2023)
 Reported Trait: Incident CKD with second hand smoke exposure — — Hazard ratio (HR, second hand smoke exposure and high PRS vs. no exposure and low PRS): 1.34 [1.21, 1.48] Age, sex, race, physical activity, Townsend deprivation index, alcohol consumption, total triglyceride, body mass index, hypertension, and diabetes mellitus —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011300 — — 196,354 individuals — European — UKB Full combined ancestry cohort: percent males = 57.9%
PSS011300 — — 17,890 individuals — Not reported — UKB Full combined ancestry cohort: percent males = 57.9%