PGS Publication: PGP000528

Publication Information (EuropePMC)
Title Leveraging related health phenotypes for polygenic prediction of impulsive choice, impulsive action, and impulsive personality traits in 1534 European ancestry community adults.
PubMed ID 37060189(Europe PMC)
doi 10.1111/gbb.12848
Publication Date April 14, 2023
Journal Genes Brain Behav
Author(s) Deng WQ, Belisario K, Gray JC, Levitt EE, Mohammadi-Shemirani P, Singh D, Pare G, MacKillop J.
Released in PGS Catalog: Dec. 15, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004230
(Impulsivity_combined)
 PGP000528 |
Deng WQ et al. Genes Brain Behav (2023)
 Impulsivity behavioural disinhibition measurement 3,465,707
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004230/ScoringFiles/PGS004230.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020224 PGS004230
(Impulsivity_combined)
 PSS011308|
European Ancestry|
1,534 individuals
 PGP000528 |
Deng WQ et al. Genes Brain Behav (2023)
 Reported Trait: Negative urgency β: 0.172 — R²: 0.0381
adjusted R2 only by the PRS: 0.0246		 first 10 genetic PC, sex, age, income, an indicator for genotying array version. beta between standardized PRS and standardized trait
PPM020225 PGS004230
(Impulsivity_combined)
 PSS011308|
European Ancestry|
1,534 individuals
 PGP000528 |
Deng WQ et al. Genes Brain Behav (2023)
 Reported Trait: Lack of premeditation β: 0.167 — R²: 0.0217
adjusted R2 only by the PRS: 0.0211		 first 10 genetic PC, sex, age, income, an indicator for genotying array version. beta between standardized PRS and standardized trait
PPM020226 PGS004230
(Impulsivity_combined)
 PSS011308|
European Ancestry|
1,534 individuals
 PGP000528 |
Deng WQ et al. Genes Brain Behav (2023)
 Reported Trait: Delayed reward discounting (small magnitude rewards) β: 0.166 — R²: 0.0811
adjusted R2 only by the PRS: 0.0212 %		 first 10 genetic PC, sex, age, income, an indicator for genotying array version. beta between standardized PRS and standardized trait
PPM020228 PGS004230
(Impulsivity_combined)
 PSS011308|
European Ancestry|
1,534 individuals
 PGP000528 |
Deng WQ et al. Genes Brain Behav (2023)
 Reported Trait: Delayed reward discounting (large magnitude rewards) β: 0.151 — R²: 0.1294
adjusted R2 only by the PRS: 0.0176		 first 10 genetic PC, sex, age, income, an indicator for genotying array version. beta between standardized PRS and standardized trait
PPM020227 PGS004230
(Impulsivity_combined)
 PSS011308|
European Ancestry|
1,534 individuals
 PGP000528 |
Deng WQ et al. Genes Brain Behav (2023)
 Reported Trait: Delayed reward discounting (medium magnitude rewards) β: 0.161 — R²: 0.1081
adjusted R2 only by the PRS: 0.0195 %		 first 10 genetic PC, sex, age, income, an indicator for genotying array version. beta between standardized PRS and standardized trait

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011308 — — 1,534 individuals,
43.0 % Male samples
 Mean = 34.9 years
Sd = 14.2 years		 European — NR Existing research registry at St. Joseph's Healthcare, Hamilton