Trait: behavioural disinhibition measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0006946
Description quantification of some aspect of behavioural disinhibition, including risky and impulsive behaviours. Behavioural disinhibition can be a marker for certain kinds of mental or behavioural disorders.
Trait category
Other measurement

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004230
(Impulsivity_combined)
 PGP000528 |
Deng WQ et al. Genes Brain Behav (2023)
 Impulsivity behavioural disinhibition measurement 3,465,707
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004230/ScoringFiles/PGS004230.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020224 PGS004230
(Impulsivity_combined)
 PSS011308|
European Ancestry|
1,534 individuals
 PGP000528 |
Deng WQ et al. Genes Brain Behav (2023)
 Reported Trait: Negative urgency β: 0.172 — R²: 0.0381
adjusted R2 only by the PRS: 0.0246		 first 10 genetic PC, sex, age, income, an indicator for genotying array version. beta between standardized PRS and standardized trait
PPM020225 PGS004230
(Impulsivity_combined)
 PSS011308|
European Ancestry|
1,534 individuals
 PGP000528 |
Deng WQ et al. Genes Brain Behav (2023)
 Reported Trait: Lack of premeditation β: 0.167 — R²: 0.0217
adjusted R2 only by the PRS: 0.0211		 first 10 genetic PC, sex, age, income, an indicator for genotying array version. beta between standardized PRS and standardized trait
PPM020226 PGS004230
(Impulsivity_combined)
 PSS011308|
European Ancestry|
1,534 individuals
 PGP000528 |
Deng WQ et al. Genes Brain Behav (2023)
 Reported Trait: Delayed reward discounting (small magnitude rewards) β: 0.166 — R²: 0.0811
adjusted R2 only by the PRS: 0.0212 %		 first 10 genetic PC, sex, age, income, an indicator for genotying array version. beta between standardized PRS and standardized trait
PPM020228 PGS004230
(Impulsivity_combined)
 PSS011308|
European Ancestry|
1,534 individuals
 PGP000528 |
Deng WQ et al. Genes Brain Behav (2023)
 Reported Trait: Delayed reward discounting (large magnitude rewards) β: 0.151 — R²: 0.1294
adjusted R2 only by the PRS: 0.0176		 first 10 genetic PC, sex, age, income, an indicator for genotying array version. beta between standardized PRS and standardized trait
PPM020227 PGS004230
(Impulsivity_combined)
 PSS011308|
European Ancestry|
1,534 individuals
 PGP000528 |
Deng WQ et al. Genes Brain Behav (2023)
 Reported Trait: Delayed reward discounting (medium magnitude rewards) β: 0.161 — R²: 0.1081
adjusted R2 only by the PRS: 0.0195 %		 first 10 genetic PC, sex, age, income, an indicator for genotying array version. beta between standardized PRS and standardized trait

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011308 — — 1,534 individuals,
43.0 % Male samples
 Mean = 34.9 years
Sd = 14.2 years		 European — NR Existing research registry at St. Joseph's Healthcare, Hamilton