PGS Publication: PGP000533

Publication Information (EuropePMC)
Title Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography.
PubMed ID 34143812(Europe PMC)
doi 10.1371/journal.pone.0252855
Publication Date June 18, 2021
Journal PLoS One
Author(s) Skals R, Krogager ML, Appel EVR, Schnurr TM, Have CT, Gislason G, Poulsen HE, Køber L, Engstrøm T, Stender S, Hansen T, Grarup N, Lee CJ, Andersson C, Torp-Pedersen C, Weeke PE.
Released in PGS Catalog: Dec. 15, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000877
(uwGRS53_IR)
 PGP000223 |
Lotta LA et al. Nat Genet (2016)
 Insulin resistance insulin resistance 53
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000877/ScoringFiles/PGS000877.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020263 PGS000877
(uwGRS53_IR)
 PSS011314|
European Ancestry|
4,963 individuals
 PGP000533 |
Skals R et al. PLoS One (2021)
|Ext.		 Reported Trait: Coronary artey disease — — Odds Ratio (OR, top 25% vs bottom 25%): 1.21 [1.03, 1.42] — —
PPM020264 PGS000877
(uwGRS53_IR)
 PSS011314|
European Ancestry|
4,963 individuals
 PGP000533 |
Skals R et al. PLoS One (2021)
|Ext.		 Reported Trait: Coronary artey disease — — Odds Ratio (OR, top 25% vs bottom 25%): 1.25 [1.06, 1.48] Gender, age, smoking status, hypertension —
PPM020265 PGS000877
(uwGRS53_IR)
 PSS011314|
European Ancestry|
4,963 individuals
 PGP000533 |
Skals R et al. PLoS One (2021)
|Ext.		 Reported Trait: Three-vessel coronary artery disease — — Odds Ratio (OR, top 25% vs bottom 25%): 1.41 [1.1, 1.82] Gender, age, smoking status, hypertension —
PPM020266 PGS000877
(uwGRS53_IR)
 PSS011314|
European Ancestry|
4,963 individuals
 PGP000533 |
Skals R et al. PLoS One (2021)
|Ext.		 Reported Trait: Three-vessel coronary artery disease — — Odds Ratio (OR, top 25% vs bottom 25%): 1.36 [1.06, 1.47] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011314 Cases are individuals with significant coronary artery disease. Of the 2,725 individuals with coronary artery disease, 1,345 were defined as having one-vessel, 705 were defined as having two-vessel and 675 were defined as having three-vessel coronary artey disease. —
[
  • 2,725 cases
  • , 2,238 controls
]
,
64.7 % Male samples
 Mean = 65.2 years
Sd = 11.3 years		 European — COGEN —