Trait: insulin resistance

Experimental Factor Ontology (EFO) Information
Identifier EFO_0002614
Description diminished effectiveness of insulin in lowering plasma glucose levels
Trait category
Other trait
Synonyms 2 synonyms
  • Drug resistance to insulin (disorder)
  • IR
Mapped terms 5 mapped terms
  • HP:0000855
  • MP:0005331
  • MeSH:D007333
  • MedDRA:10022489
  • NCIt:C113101

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Loading, please wait
Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000877
(uwGRS53_IR)
PGP000223 |
Lotta LA et al. Nat Genet (2016)
Insulin resistanceinsulin resistance53
G
-
E
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000877/ScoringFiles/PGS000877.txt.gz
Showing 1 to 1 of 1 rows

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

Loading, please wait
PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM002508PGS000877
(uwGRS53_IR)
PSS001129|
Ancestry Not Reported|
2,764 individuals
PGP000223 |
Lotta LA et al. Nat Genet (2016)
Reported Trait: Insulin sensitivityβ: -0.09 (0.019)
PPM002509PGS000877
(uwGRS53_IR)
PSS001130|
Ancestry Not Reported|
4,769 individuals
PGP000223 |
Lotta LA et al. Nat Genet (2016)
Reported Trait: Insulin sensitivity indexβ: -0.1 (0.016)
PPM002510PGS000877
(uwGRS53_IR)
PSS001132|
Multi-ancestry (including European)|
276,194 individuals
PGP000223 |
Lotta LA et al. Nat Genet (2016)
Reported Trait: Type II diabetesOR: 1.12 [1.11, 1.14]
PPM002511PGS000877
(uwGRS53_IR)
PSS001128|
Ancestry Not Reported|
194,427 individuals
PGP000223 |
Lotta LA et al. Nat Genet (2016)
Reported Trait: Coronary heart diseaseOR: 1.05 [1.04, 1.06]
PPM002512PGS000877
(uwGRS53_IR)
PSS001134|
Ancestry Not Reported|
9,747 individuals
PGP000223 |
Lotta LA et al. Nat Genet (2016)
Reported Trait: Leg fat massBeta (top 20% vs bottom 20%): -712.0 [-905.0, -519.0]Beta value = fat mass in grams
PPM002513PGS000877
(uwGRS53_IR)
PSS001131|
European Ancestry|
16,687 individuals
PGP000223 |
Lotta LA et al. Nat Genet (2016)
Reported Trait: Incident type II diabetesHazard Ratio (HR, top 20% vs. bottom 20%): 1.39 [1.25, 1.54]
PPM002514PGS000877
(uwGRS53_IR)
PSS001133|
Ancestry Not Reported|
10,330 individuals
PGP000223 |
Lotta LA et al. Nat Genet (2016)
Reported Trait: Alanine aminotransferase levelsβ: 0.054 (0.009)
PPM002515PGS000877
(uwGRS53_IR)
PSS001133|
Ancestry Not Reported|
10,330 individuals
PGP000223 |
Lotta LA et al. Nat Genet (2016)
Reported Trait: Gamma glutamyl transferase levelsβ: 0.054 (0.009)
PPM020263PGS000877
(uwGRS53_IR)
PSS011314|
European Ancestry|
4,963 individuals
PGP000533 |
Skals R et al. PLoS One (2021)
|Ext.
Reported Trait: Coronary artey diseaseOdds Ratio (OR, top 25% vs bottom 25%): 1.21 [1.03, 1.42]
PPM020264PGS000877
(uwGRS53_IR)
PSS011314|
European Ancestry|
4,963 individuals
PGP000533 |
Skals R et al. PLoS One (2021)
|Ext.
Reported Trait: Coronary artey diseaseOdds Ratio (OR, top 25% vs bottom 25%): 1.25 [1.06, 1.48]Gender, age, smoking status, hypertension
PPM020265PGS000877
(uwGRS53_IR)
PSS011314|
European Ancestry|
4,963 individuals
PGP000533 |
Skals R et al. PLoS One (2021)
|Ext.
Reported Trait: Three-vessel coronary artery diseaseOdds Ratio (OR, top 25% vs bottom 25%): 1.41 [1.1, 1.82]Gender, age, smoking status, hypertension
PPM020266PGS000877
(uwGRS53_IR)
PSS011314|
European Ancestry|
4,963 individuals
PGP000533 |
Skals R et al. PLoS One (2021)
|Ext.
Reported Trait: Three-vessel coronary artery diseaseOdds Ratio (OR, top 25% vs bottom 25%): 1.36 [1.06, 1.47]
Showing 1 to 12 of 12 rows

Evaluated Samples

Loading, please wait
PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS001128Cases were individuals with coronary heart disease
[
  • 63,746 cases
  • , 130,681 controls
]
Not reportedCARDIoGRAMplusC4D
PSS001129All individuals had insulin sensitivity measured by euglycemic clamp or insulin suppression.2,764 individualsNot reportedGENESIS
PSS001130All individuals had insulin sensitivity index calculated via frequently sampled oral glucose toleran... ce tests.Show more4,769 individualsNot reportedMAGIC
PSS001131Cases were individuals that developed type II diabetesMean = 8.0 years
[
  • 7,420 cases
  • , 9,267 controls
]
EuropeanInterAct
PSS001132Cases were individuals with type II diabetes
[
  • 45,836 cases
  • , 230,358 controls
]
European, NREuropean, NRDIAGRAM, InterAct, UKB
PSS001133Individuals were used to calculate alanine aminotransferase and gamma glutamyl transferase levels10,330 individualsNot reportedFenland
PSS001134Individuals were used to calculate leg fat mass using dual-energy X-ray absorptiometry.9,747 individualsNot reportedFenland
PSS011314Cases are individuals with significant coronary artery disease. Of the 2,725 individuals with corona... ry artery disease, 1,345 were defined as having one-vessel, 705 were defined as having two-vessel and 675 were defined as having three-vessel coronary artey disease.Show more
[
  • 2,725 cases
  • , 2,238 controls
]
,
64.7 % Male samples
Mean = 65.2 years
Sd = 11.3 years
EuropeanCOGEN
Showing 1 to 8 of 8 rows