PGS Publication: PGP000584

Publication Information (EuropePMC)
Title Transdiagnostic behavioral and genetic contributors to repetitive negative thinking: A machine learning approach.
PubMed ID 37178517(Europe PMC)
doi 10.1016/j.jpsychires.2023.05.039
Publication Date May 5, 2023
Journal J Psychiatr Res
Author(s) Forthman KL, Kuplicki R, Yeh HW, Khalsa SS, Paulus MP, Guinjoan SM.
Released in PGS Catalog: Feb. 20, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004608
(neuroticism)
 PGP000584 |
Forthman KL et al. J Psychiatr Res (2023)
 Neuroticism neuroticism measurement 1,000,537
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004608/ScoringFiles/PGS004608.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020770 PGS004608
(neuroticism)
 PSS011400|
Multi-ancestry (including European)|
486 individuals
 PGP000584 |
Forthman KL et al. J Psychiatr Res (2023)
 Reported Trait: Repetitive negative thinking — — R²: 0.0275
p-value (inferior to): 0.001		 Age, sex, PCs of predictor features from behavioral and neuropsychological tasks —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011400 — — 321 individuals — European — T1000 —
PSS011400 — — 90 individuals — Native American — T1000 —
PSS011400 — — 31 individuals — African unspecified — T1000 —
PSS011400 — — 20 individuals — Hispanic or Latin American — T1000 —
PSS011400 — — 4 individuals — Asian unspecified — T1000 —
PSS011400 — — 20 individuals — Not reported — T1000 —