PGS Publication: PGP000627

Publication Information (EuropePMC)
Title Joint association between education and polygenic risk score for incident coronary heart disease events: a longitudinal population-based study of 26 203 men and women.
PubMed ID 33408166(Europe PMC)
doi 10.1136/jech-2020-214358
Publication Date Jan. 6, 2021
Journal J Epidemiol Community Health
Author(s) Martikainen P, Korhonen K, Jelenkovic A, Lahtinen H, Havulinna A, Ripatti S, Borodulin K, Salomaa V,...  Davey Smith G, Silventoinen K.Show more
Released in PGS Catalog: May 8, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000011
(GRS50)
PGP000004 |
Tada H et al. Eur Heart J (2015)
Coronary artery diseasecoronary artery disease50
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000011/ScoringFiles/PGS000011.txt.gz
PGS000012
(GRS49K)
PGP000005 |
Abraham G et al. Eur Heart J (2016)
Coronary artery diseasecoronary artery disease49,310
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000012/ScoringFiles/PGS000012.txt.gz
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM021300PGS000012
(GRS49K)
PSS011680|
European Ancestry|
26,203 individuals
PGP000627 |
Martikainen P et al. J Epidemiol Community Health (2021)
|Ext.		Reported Trait: Incident coronary heart disease hospitalization or death——Hazard Ratio (HR, top 25% vs bottom 25%): 2.26 [1.97, 2.59]Age as timescale, sex, region of residence, calendar year, study batch, PCs(1-10)—
PPM021301PGS000012
(GRS49K)
PSS011680|
European Ancestry|
26,203 individuals
PGP000627 |
Martikainen P et al. J Epidemiol Community Health (2021)
|Ext.		Reported Trait: Incident coronary heart disease hospitalization or death——Hazard Ratio (HR, top 25% vs bottom 25%): 2.27 [1.98, 2.61]Age as timescale, sex, region of residence, calendar year, study batch, PCs(1-10), education—
PPM021302PGS000012
(GRS49K)
PSS011680|
European Ancestry|
26,203 individuals
PGP000627 |
Martikainen P et al. J Epidemiol Community Health (2021)
|Ext.		Reported Trait: Incident coronary heart disease hospitalization or death——Hazard Ratio (HR, top 25% vs bottom 25%): 2.12 [1.48, 2.43]Age as timescale, sex, region of residence, calendar year, study batch, PCs(1-10), smoking, alcohol ... use, body mass index, high-density lipoprotein and total cholesterol, blood pressure, diabetesShow more—
PPM021303PGS000011
(GRS50)
PSS011680|
European Ancestry|
26,203 individuals
PGP000627 |
Martikainen P et al. J Epidemiol Community Health (2021)
|Ext.		Reported Trait: Incident coronary heart disease hospitalization or death——Hazard Ratio (HR, top 25% vs bottom 25%): 1.55 [1.38, 1.76]Age as timescale, sex, region of residence, calendar year, study batch, PCs(1-10)—
PPM021304PGS000011
(GRS50)
PSS011680|
European Ancestry|
26,203 individuals
PGP000627 |
Martikainen P et al. J Epidemiol Community Health (2021)
|Ext.		Reported Trait: Incident coronary heart disease hospitalization or death——Hazard Ratio (HR, top 25% vs bottom 25%): 1.56 [1.38, 1.77]Age as timescale, sex, region of residence, calendar year, study batch, PCs(1-10), education—
PPM021305PGS000011
(GRS50)
PSS011680|
European Ancestry|
26,203 individuals
PGP000627 |
Martikainen P et al. J Epidemiol Community Health (2021)
|Ext.		Reported Trait: Incident coronary heart disease hospitalization or death——Hazard Ratio (HR, top 25% vs bottom 25%): 1.53 [1.35, 1.73]Age as timescale, sex, region of residence, calendar year, study batch, PCs(1-10), smoking, alcohol ... use, body mass index, high-density lipoprotein and total cholesterol, blood pressure, diabetesShow more—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011680At baseline, all individuals were free from coronary heart disease (CHD). Cases included individuals...  who were hospitalised due to CHD or suffered a fatal CHD event. CHD events were defined for non-fatal cases as the International Classification of Diseases ninth revision (ICD-9) codes 410 and 4110 (years 1992-1995) and ICD-10 codes I200, I21 or I22 (1996-2015) and Nordic Medico-Statistical Committee codes for coronary artery bypass graft or percutaneous coronary intervention in the hospital discharge register, and for fatal cases as ICD-9 codes 410-414 and 798 (not 7980A) and ICD-10 codes I20-25, I46, R96 and R98 in the causes of death register.Show moreMean = 13.8 years
[
  • 2,063 cases
  • , 24,140 controls
]
,
46.74 % Male samples
Mean = 48.0 yearsEuropean
(Finnish)		—FINRISK—
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