PGS Publication: PGP000627

Publication Information (EuropePMC)
Title Joint association between education and polygenic risk score for incident coronary heart disease events: a longitudinal population-based study of 26 203 men and women.
PubMed ID 33408166(Europe PMC)
doi 10.1136/jech-2020-214358
Publication Date Jan. 6, 2021
Journal J Epidemiol Community Health
Author(s) Martikainen P, Korhonen K, Jelenkovic A, Lahtinen H, Havulinna A, Ripatti S, Borodulin K, Salomaa V, Davey Smith G, Silventoinen K.
Released in PGS Catalog: May 8, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000011
(GRS50)
 PGP000004 |
Tada H et al. Eur Heart J (2015)
 Coronary artery disease coronary artery disease 50
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000011/ScoringFiles/PGS000011.txt.gz
PGS000012
(GRS49K)
 PGP000005 |
Abraham G et al. Eur Heart J (2016)
 Coronary artery disease coronary artery disease 49,310
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000012/ScoringFiles/PGS000012.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021300 PGS000012
(GRS49K)
 PSS011680|
European Ancestry|
26,203 individuals
 PGP000627 |
Martikainen P et al. J Epidemiol Community Health (2021)
|Ext.		 Reported Trait: Incident coronary heart disease hospitalization or death — — Hazard Ratio (HR, top 25% vs bottom 25%): 2.26 [1.97, 2.59] Age as timescale, sex, region of residence, calendar year, study batch, PCs(1-10) —
PPM021301 PGS000012
(GRS49K)
 PSS011680|
European Ancestry|
26,203 individuals
 PGP000627 |
Martikainen P et al. J Epidemiol Community Health (2021)
|Ext.		 Reported Trait: Incident coronary heart disease hospitalization or death — — Hazard Ratio (HR, top 25% vs bottom 25%): 2.27 [1.98, 2.61] Age as timescale, sex, region of residence, calendar year, study batch, PCs(1-10), education —
PPM021302 PGS000012
(GRS49K)
 PSS011680|
European Ancestry|
26,203 individuals
 PGP000627 |
Martikainen P et al. J Epidemiol Community Health (2021)
|Ext.		 Reported Trait: Incident coronary heart disease hospitalization or death — — Hazard Ratio (HR, top 25% vs bottom 25%): 2.12 [1.48, 2.43] Age as timescale, sex, region of residence, calendar year, study batch, PCs(1-10), smoking, alcohol use, body mass index, high-density lipoprotein and total cholesterol, blood pressure, diabetes —
PPM021303 PGS000011
(GRS50)
 PSS011680|
European Ancestry|
26,203 individuals
 PGP000627 |
Martikainen P et al. J Epidemiol Community Health (2021)
|Ext.		 Reported Trait: Incident coronary heart disease hospitalization or death — — Hazard Ratio (HR, top 25% vs bottom 25%): 1.55 [1.38, 1.76] Age as timescale, sex, region of residence, calendar year, study batch, PCs(1-10) —
PPM021304 PGS000011
(GRS50)
 PSS011680|
European Ancestry|
26,203 individuals
 PGP000627 |
Martikainen P et al. J Epidemiol Community Health (2021)
|Ext.		 Reported Trait: Incident coronary heart disease hospitalization or death — — Hazard Ratio (HR, top 25% vs bottom 25%): 1.56 [1.38, 1.77] Age as timescale, sex, region of residence, calendar year, study batch, PCs(1-10), education —
PPM021305 PGS000011
(GRS50)
 PSS011680|
European Ancestry|
26,203 individuals
 PGP000627 |
Martikainen P et al. J Epidemiol Community Health (2021)
|Ext.		 Reported Trait: Incident coronary heart disease hospitalization or death — — Hazard Ratio (HR, top 25% vs bottom 25%): 1.53 [1.35, 1.73] Age as timescale, sex, region of residence, calendar year, study batch, PCs(1-10), smoking, alcohol use, body mass index, high-density lipoprotein and total cholesterol, blood pressure, diabetes —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011680 At baseline, all individuals were free from coronary heart disease (CHD). Cases included individuals who were hospitalised due to CHD or suffered a fatal CHD event. CHD events were defined for non-fatal cases as the International Classification of Diseases ninth revision (ICD-9) codes 410 and 4110 (years 1992-1995) and ICD-10 codes I200, I21 or I22 (1996-2015) and Nordic Medico-Statistical Committee codes for coronary artery bypass graft or percutaneous coronary intervention in the hospital discharge register, and for fatal cases as ICD-9 codes 410-414 and 798 (not 7980A) and ICD-10 codes I20-25, I46, R96 and R98 in the causes of death register. Mean = 13.8 years
[
  • 2,063 cases
  • , 24,140 controls
]
,
46.74 % Male samples
 Mean = 48.0 years European
(Finnish)		 — FINRISK —