PGS Publication: PGP000658

Publication Information (EuropePMC)
Title Genetic Predisposition, Sedentary Behavior, and Incident Coronary Artery Disease: A Prospective Chinese Cohort Study.
PubMed ID 37703277(Europe PMC)
doi 10.1249/mss.0000000000003277
Publication Date Aug. 30, 2023
Journal Med Sci Sports Exerc
Author(s) Hu C, Huang K, Cai C, Liu F, Li J, Hu D, Zhao Y, Liu X, Cao J, Chen S, Li H, Yu L, Li Y, Shen C, Huang J, Gu D, Lu X.
Released in PGS Catalog: July 31, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002262
(metaPRS_CAD)
 PGP000289 |
Lu X et al. Eur Heart J (2022)
 Coronary artery disease coronary artery disease 540
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002262/ScoringFiles/PGS002262.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021704 PGS002262
(metaPRS_CAD)
 PSS011752|
East Asian Ancestry|
39,164 individuals
 PGP000658 |
Hu C et al. Med Sci Sports Exerc (2023)
|Ext.		 Reported Trait: Incident CAD HR: 1.38 [1.3, 1.47] — — Age, sex, cohort source, living geographical zone, urban or rural residents, education attainment, family history of CVD, current smoking status, drinking, healthy diet score, sleep duration, physical activity level, BMI, hypertension, diabetes, and dyslipidemia —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011752 — Median = 11.6 years 39,164 individuals,
42.4 % Male samples
 Mean = 53.9 years
Sd = 10.5 years		 East Asian
(Chinese)		 — CIMIC, ChinaMUCA-1998, InterASIA —