PGS Publication: PGP000669

Publication Information (EuropePMC)
Title Polygenic Risk, Rare Variants, and Family History: Independent and Additive Effects on Coronary Heart Disease.
PubMed ID 38939477(Europe PMC)
doi 10.1016/j.jacadv.2023.100567
Publication Date Aug. 26, 2023
Journal JACC Adv
Author(s) Saadatagah S, Naderian M, Dikilitas O, Hamed ME, Bangash H, Kullo IJ.
Released in PGS Catalog: Aug. 29, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (including European)
Multi-ancestry (excluding European)
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South Asian
Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000018
(metaGRS_CAD)
 PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
 Coronary artery disease coronary artery disease 1,745,179
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000018/ScoringFiles/PGS000018.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021742 PGS000018
(metaGRS_CAD)
 PSS011775|
Multi-ancestry (including European)|
199,997 individuals
 PGP000669 |
Saadatagah S et al. JACC Adv (2023)
|Ext.		 Reported Trait: Coronary heart disease onset > 70 years — — Odds ratio (OR, top 5th percentile vs 20-80th percentile): 1.91 [1.68, 2.17] Sex, 4 PCs —
PPM021743 PGS000018
(metaGRS_CAD)
 PSS011775|
Multi-ancestry (including European)|
199,997 individuals
 PGP000669 |
Saadatagah S et al. JACC Adv (2023)
|Ext.		 Reported Trait: Coronary heart disease onset < 50 years — — Odds ratio (OR, top 5th percentile vs 20-80th percentile): 3.25 [2.73, 3.85] Sex, 4 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011775 — — 190,489 individuals — European — UKB —
PSS011775 — — 4,412 individuals — South Asian — UKB —
PSS011775 — — 3,795 individuals — African unspecified — UKB —
PSS011775 — — 1,230 individuals — East Asian — UKB —
PSS011775 — — 71 individuals — Not reported — UKB —