PGS Publication: PGP000689

Publication Information (EuropePMC)
Title Genetic risk score for coronary artery calcification and its predictive ability for coronary artery disease.
PubMed ID 39483246(Europe PMC)
doi 10.1016/j.ajpc.2024.100884
Publication Date Oct. 10, 2024
Journal Am J Prev Cardiol
Author(s) Mishra PP, Mishra BH, Lyytikäinen LP, Goebeler S, Martiskainen M, Hakamaa E, Kleber ME, Delgado GE, März W, Kähönen M, Karhunen PJ, Lehtimäki T.
Released in PGS Catalog: Nov. 21, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Asian Ancestries
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005096
(CAC_GRS)
 PGP000689 |
Mishra PP et al. Am J Prev Cardiol (2024)
 Coronary artery calcification coronary artery calcification 11
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005096/ScoringFiles/PGS005096.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022192 PGS005096
(CAC_GRS)
 PSS011838|
European Ancestry|
2,742 individuals
 PGP000689 |
Mishra PP et al. Am J Prev Cardiol (2024)
 Reported Trait: Coronary artery disease OR: 1.41 [1.28, 1.55] — — Age, sex, systolic blood pressure, total cholesterol, HDL cholesterol, smoking status, hypertension medication, 5 PCs —
PPM022193 PGS005096
(CAC_GRS)
 PSS011839|
European Ancestry|
622 individuals
 PGP000689 |
Mishra PP et al. Am J Prev Cardiol (2024)
 Reported Trait: Coronary artery disease OR: 4.2 [1.74, 10.52] — — Age, sex, BMI, smoking status, hypertension medication, 5 PCs —
PPM022194 PGS005096
(CAC_GRS)
 PSS011840|
European Ancestry|
133 individuals
 PGP000689 |
Mishra PP et al. Am J Prev Cardiol (2024)
 Reported Trait: Coronary artery disease OR: 1.79 [1.05, 3.21] — — Age, sex, systolic blood pressure, total cholesterol, HDL cholesterol, smoking status, hypertension medication, 5 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011839 — —
[
  • 327 cases
  • , 295 controls
]
,
75.0 % Male samples
 — European — TSDS —
PSS011840 — —
[
  • 98 cases
  • , 35 controls
]
,
71.0 % Male samples
 — European — TVS —
PSS011838 — —
[
  • 1,912 cases
  • , 830 controls
]
,
71.0 % Male samples
 — European — LURIC —