Trait: coronary artery calcification

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004723
Description Calcification of the coronary artery, used as a measure of coronary atherosclerosis, a risk factor for myocardial infarction.
Trait category
Cardiovascular disease
Mapped term MedDRA:10064747

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS005096
(CAC_GRS)
PGP000689 |
Mishra PP et al. Am J Prev Cardiol (2024)
Coronary artery calcification coronary artery calcification 11
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005096/ScoringFiles/PGS005096.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022192 PGS005096
(CAC_GRS)
PSS011838|
European Ancestry|
2,742 individuals
PGP000689 |
Mishra PP et al. Am J Prev Cardiol (2024)
Reported Trait: Coronary artery disease OR: 1.41 [1.28, 1.55] Age, sex, systolic blood pressure, total cholesterol, HDL cholesterol, smoking status, hypertension medication, 5 PCs
PPM022193 PGS005096
(CAC_GRS)
PSS011839|
European Ancestry|
622 individuals
PGP000689 |
Mishra PP et al. Am J Prev Cardiol (2024)
Reported Trait: Coronary artery disease OR: 4.2 [1.74, 10.52] Age, sex, BMI, smoking status, hypertension medication, 5 PCs
PPM022194 PGS005096
(CAC_GRS)
PSS011840|
European Ancestry|
133 individuals
PGP000689 |
Mishra PP et al. Am J Prev Cardiol (2024)
Reported Trait: Coronary artery disease OR: 1.79 [1.05, 3.21] Age, sex, systolic blood pressure, total cholesterol, HDL cholesterol, smoking status, hypertension medication, 5 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011839
[
  • 327 cases
  • , 295 controls
]
,
75.0 % Male samples
European TSDS
PSS011840
[
  • 98 cases
  • , 35 controls
]
,
71.0 % Male samples
European TVS
PSS011838
[
  • 1,912 cases
  • , 830 controls
]
,
71.0 % Male samples
European LURIC