PGS Publication: PGP000714

Publication Information (EuropePMC)
Title The interaction and mediation effects between the host genetic factors and Epstein-Barr virus VCA-IgA in the risk of nasopharyngeal carcinoma.
PubMed ID 37970759(Europe PMC)
doi 10.1002/jmv.29224
Publication Date Nov. 1, 2023
Journal J Med Virol
Author(s) Diao H, Xue WQ, Wang TM, Yang DW, Deng CM, Li DH, Zhang WL, Liao Y, Wu YX, Chen XY, Zhou T, Li XZ, Zhang PF, Zheng XH, Zhang SD, Hu YZ, Cao SM, Liu Q, Ye WM, He YQ, Jia WH.
Released in PGS Catalog: March 17, 2025

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002291
(PRS12_NPC)
 PGP000320 |
He YQ et al. Nat Commun (2022)
 Nasopharyngeal carcinoma nasopharyngeal neoplasm 12
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002291/ScoringFiles/PGS002291.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022453 PGS002291
(PRS12_NPC)
 PSS011948|
East Asian Ancestry|
4,804 individuals
 PGP000714 |
Diao H et al. J Med Virol (2023)
|Ext.		 Reported Trait: Nasopharyngeal carcinoma — — Odds ratio (OR, high vs low tertile): 2.57 [2.28, 2.9] — —
PPM022454 PGS002291
(PRS12_NPC)
 PSS011948|
East Asian Ancestry|
4,804 individuals
 PGP000714 |
Diao H et al. J Med Virol (2023)
|Ext.		 Reported Trait: Nasopharyngeal carcinoma x VCA-IgA interaction — — Odds ratio (OR, positive VCA-IgA and high PRS vs. negative VCA-IgA and low PRS): 257.96 [178.2, 386.23]
Synergy index (SI): 3.1 [2.17, 4.44]		 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011948 — —
[
  • 2,393 cases
  • , 2,411 controls
]
 — East Asian — EPI-NPC-2005, NPCGEE —