| Predicted Trait | |
| Reported Trait | Coronary artery disease |
| Mapped Trait(s) | coronary artery disease (EFO_0001645) |
| Score Construction | |
| PGS Name | CAD-GRS |
| Development Method | |
| Name | Known CAD loci |
| Parameters | NR |
| Variants | |
| Original Genome Build | NR |
| Number of Variants | 161 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000654 |
| Citation (link to publication) | Huang Y et al. Circ Genom Precis Med (2020) |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
|---|---|---|---|
GWAS Catalog: GCST005194 Europe PMC: 29212778 |
296,525 individuals | Not reported | UKB |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
GWAS Catalog: GCST003116 Europe PMC: 26343387 |
141,217 individuals | European | 41 cohorts
|
— | — | — | — | Used to determine SNP weights |
GWAS Catalog: GCST003116 Europe PMC: 26343387 |
3,139 individuals | African American or Afro-Caribbean | 41 cohorts
|
— | — | — | — | Used to determine SNP weights |
GWAS Catalog: GCST003116 Europe PMC: 26343387 |
4,095 individuals | Hispanic or Latin American | 41 cohorts
|
— | — | — | — | Used to determine SNP weights |
GWAS Catalog: GCST003116 Europe PMC: 26343387 |
25,557 individuals | South Asian | 41 cohorts
|
— | — | — | — | Used to determine SNP weights |
GWAS Catalog: GCST003116 Europe PMC: 26343387 |
2,268 individuals | Greater Middle Eastern (Middle Eastern, North African or Persian) | 41 cohorts
|
— | — | — | — | Used to determine SNP weights |
GWAS Catalog: GCST003116 Europe PMC: 26343387 |
11,323 individuals | East Asian | 41 cohorts
|
— | — | — | — | Used to determine SNP weights |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM021399 | PSS011730| European Ancestry| 317,509 individuals |
PGP000654 | Huang Y et al. Circ Genom Precis Med (2020) |
Reported Trait: Prevalent coronary artery disease | OR: 1.41 [1.38, 1.44] | — | — | Age, population stratification, smoking status, alcohol consumption, BMI, history of diabetes or hypertension, cholesterol medication use, education, Townsend deprivation index | — |
| PPM021400 | PSS011731| European Ancestry| 146,246 individuals |
PGP000654 | Huang Y et al. Circ Genom Precis Med (2020) |
Reported Trait: Prevalent coronary artery disease | OR: 1.44 [1.4, 1.48] | — | — | Age, population stratification, smoking status, alcohol consumption, BMI, history of diabetes or hypertension, cholesterol medication use, education, Townsend deprivation index | — |
| PPM021401 | PSS011732| European Ancestry| 171,263 individuals |
PGP000654 | Huang Y et al. Circ Genom Precis Med (2020) |
Reported Trait: Prevalent coronary artery disease | OR: 1.33 [1.27, 1.39] | — | — | Age, population stratification, smoking status, alcohol consumption, BMI, history of diabetes or hypertension, cholesterol medication use, education, Townsend deprivation index | — |
| PPM021402 | PSS011727| European Ancestry| 307,151 individuals |
PGP000654 | Huang Y et al. Circ Genom Precis Med (2020) |
Reported Trait: Incident coronary artery disease | OR: 1.34 [1.31, 1.36] | — | — | Age, population stratification, smoking status, alcohol consumption, BMI, history of diabetes or hypertension, cholesterol medication use, education, Townsend deprivation index | — |
| PPM021403 | PSS011728| European Ancestry| 138,270 individuals |
PGP000654 | Huang Y et al. Circ Genom Precis Med (2020) |
Reported Trait: Incident coronary artery disease | OR: 1.38 [1.34, 1.41] | — | — | Age, population stratification, smoking status, alcohol consumption, BMI, history of diabetes or hypertension, cholesterol medication use, education, Townsend deprivation index | — |
| PPM021404 | PSS011729| European Ancestry| 168,881 individuals |
PGP000654 | Huang Y et al. Circ Genom Precis Med (2020) |
Reported Trait: Incident coronary artery disease | OR: 1.25 [1.21, 1.3] | — | — | Age, population stratification, smoking status, alcohol consumption, BMI, history of diabetes or hypertension, cholesterol medication use, education, Townsend deprivation index | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS011727 | A participant was defined as a CAD case if he/she had at least one occurrence of International Classification of Diseases, 10th edition (ICD-10) codes I21-I25 (covering ischemic heart diseases) or at least one occurrence of the following codes in Office of Population Censuses and Surveys Classification of Interventions and Procedures, version 4 (OPCS-4): K40- K46, K49, K50 or K75, which include replacement, transluminal balloon angioplasty, and other therapeutic transluminal operations on coronary artery, and percutaneous transluminal balloon angioplasty and insertion of stents. Death because of CAD was defined as an occurrence of any of the ICD-10 codes stated above as the primary cause of death. Primary incident CAD events were either captured on the earliest date of CAD event/CAD death after enrollment, or censored at the end of HES-based follow-up or at time of competing death, whichever occurred first. Those who have had CAD diagnosis before enrollment were excluded from the incident CAD analysis. 10358 CAD cases were prevalent and 9847 were incident. | Median = [0.0, 8.4] years | [ ,
46.1 % Male samples |
Mean = 57.4 years Sd = 8.0 years |
European | — | UKB | — |
| PSS011728 | A participant was defined as a CAD case if he/she had at least one occurrence of International Classification of Diseases, 10th edition (ICD-10) codes I21-I25 (covering ischemic heart diseases) or at least one occurrence of the following codes in Office of Population Censuses and Surveys Classification of Interventions and Procedures, version 4 (OPCS-4): K40- K46, K49, K50 or K75, which include replacement, transluminal balloon angioplasty, and other therapeutic transluminal operations on coronary artery, and percutaneous transluminal balloon angioplasty and insertion of stents. Death because of CAD was defined as an occurrence of any of the ICD-10 codes stated above as the primary cause of death. Primary incident CAD events were either captured on the earliest date of CAD event/CAD death after enrollment, or censored at the end of HES-based follow-up or at time of competing death, whichever occurred first. Those who have had CAD diagnosis before enrollment were excluded from the incident CAD analysis. 7976 CAD cases were prevalent and 6774 were incident. | Median = [0.0, 8.4] years | [ ,
100.0 % Male samples |
Mean = 57.6 years Sd = 8.1 years |
European | — | UKB | — |
| PSS011729 | A participant was defined as a CAD case if he/she had at least one occurrence of International Classification of Diseases, 10th edition (ICD-10) codes I21-I25 (covering ischemic heart diseases) or at least one occurrence of the following codes in Office of Population Censuses and Surveys Classification of Interventions and Procedures, version 4 (OPCS-4): K40- K46, K49, K50 or K75, which include replacement, transluminal balloon angioplasty, and other therapeutic transluminal operations on coronary artery, and percutaneous transluminal balloon angioplasty and insertion of stents. Death because of CAD was defined as an occurrence of any of the ICD-10 codes stated above as the primary cause of death. Primary incident CAD events were either captured on the earliest date of CAD event/CAD death after enrollment, or censored at the end of HES-based follow-up or at time of competing death, whichever occurred first. Those who have had CAD diagnosis before enrollment were excluded from the incident CAD analysis. 2382 CAD cases were prevalent and 3073 were incident. | Median = [0.0, 8.4] years | [ ,
0.0 % Male samples |
Mean = 57.2 years Sd = 7.9 years |
European | — | UKB | — |
| PSS011730 | A participant was defined as a CAD case if he/she had at least one occurrence of International Classification of Diseases, 10th edition (ICD-10) codes I21-I25 (covering ischemic heart diseases) or at least one occurrence of the following codes in Office of Population Censuses and Surveys Classification of Interventions and Procedures, version 4 (OPCS-4): K40- K46, K49, K50 or K75, which include replacement, transluminal balloon angioplasty, and other therapeutic transluminal operations on coronary artery, and percutaneous transluminal balloon angioplasty and insertion of stents. Death because of CAD was defined as an occurrence of any of the ICD-10 codes stated above as the primary cause of death. Primary incident CAD events were either captured on the earliest date of CAD event/CAD death after enrollment, or censored at the end of HES-based follow-up or at time of competing death, whichever occurred first. Those who have had CAD diagnosis before enrollment were excluded from the incident CAD analysis. 10358 CAD cases were prevalent and 9847 were incident. | Median = [0.0, 8.4] years | [ ,
46.1 % Male samples |
Mean = 57.4 years Sd = 8.0 years |
European | — | UKB | — |
| PSS011731 | A participant was defined as a CAD case if he/she had at least one occurrence of International Classification of Diseases, 10th edition (ICD-10) codes I21-I25 (covering ischemic heart diseases) or at least one occurrence of the following codes in Office of Population Censuses and Surveys Classification of Interventions and Procedures, version 4 (OPCS-4): K40- K46, K49, K50 or K75, which include replacement, transluminal balloon angioplasty, and other therapeutic transluminal operations on coronary artery, and percutaneous transluminal balloon angioplasty and insertion of stents. Death because of CAD was defined as an occurrence of any of the ICD-10 codes stated above as the primary cause of death. Primary incident CAD events were either captured on the earliest date of CAD event/CAD death after enrollment, or censored at the end of HES-based follow-up or at time of competing death, whichever occurred first. Those who have had CAD diagnosis before enrollment were excluded from the incident CAD analysis. 7976 CAD cases were prevalent and 6774 were incident. | Median = [0.0, 8.4] years | [ ,
100.0 % Male samples |
Mean = 57.6 years Sd = 8.1 years |
European | — | UKB | — |
| PSS011732 | A participant was defined as a CAD case if he/she had at least one occurrence of International Classification of Diseases, 10th edition (ICD-10) codes I21-I25 (covering ischemic heart diseases) or at least one occurrence of the following codes in Office of Population Censuses and Surveys Classification of Interventions and Procedures, version 4 (OPCS-4): K40- K46, K49, K50 or K75, which include replacement, transluminal balloon angioplasty, and other therapeutic transluminal operations on coronary artery, and percutaneous transluminal balloon angioplasty and insertion of stents. Death because of CAD was defined as an occurrence of any of the ICD-10 codes stated above as the primary cause of death. Primary incident CAD events were either captured on the earliest date of CAD event/CAD death after enrollment, or censored at the end of HES-based follow-up or at time of competing death, whichever occurred first. Those who have had CAD diagnosis before enrollment were excluded from the incident CAD analysis. 2382 CAD cases were prevalent and 3073 were incident. | Median = [0.0, 8.4] years | [ ,
0.0 % Male samples |
Mean = 57.2 years Sd = 7.9 years |
European | — | UKB | — |