PGS Publication: PGP000654

Publication Information (EuropePMC)
Title Sexual Differences in Genetic Predisposition of Coronary Artery Disease.
PubMed ID 33332181(Europe PMC)
doi 10.1161/circgen.120.003147
Publication Date Dec. 17, 2020
Journal Circ Genom Precis Med
Author(s) Huang Y, Hui Q, Gwinn M, Hu YJ, Quyyumi AA, Vaccarino V, Sun YV.
Released in PGS Catalog: June 27, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004921
(CAD-GRS)
 PGP000654 |
Huang Y et al. Circ Genom Precis Med (2020)
 Coronary artery disease coronary artery disease 161
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004921/ScoringFiles/PGS004921.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021399 PGS004921
(CAD-GRS)
 PSS011730|
European Ancestry|
317,509 individuals
 PGP000654 |
Huang Y et al. Circ Genom Precis Med (2020)
 Reported Trait: Prevalent coronary artery disease OR: 1.41 [1.38, 1.44] — — Age, population stratification, smoking status, alcohol consumption, BMI, history of diabetes or hypertension, cholesterol medication use, education, Townsend deprivation index —
PPM021400 PGS004921
(CAD-GRS)
 PSS011731|
European Ancestry|
146,246 individuals
 PGP000654 |
Huang Y et al. Circ Genom Precis Med (2020)
 Reported Trait: Prevalent coronary artery disease OR: 1.44 [1.4, 1.48] — — Age, population stratification, smoking status, alcohol consumption, BMI, history of diabetes or hypertension, cholesterol medication use, education, Townsend deprivation index —
PPM021401 PGS004921
(CAD-GRS)
 PSS011732|
European Ancestry|
171,263 individuals
 PGP000654 |
Huang Y et al. Circ Genom Precis Med (2020)
 Reported Trait: Prevalent coronary artery disease OR: 1.33 [1.27, 1.39] — — Age, population stratification, smoking status, alcohol consumption, BMI, history of diabetes or hypertension, cholesterol medication use, education, Townsend deprivation index —
PPM021402 PGS004921
(CAD-GRS)
 PSS011727|
European Ancestry|
307,151 individuals
 PGP000654 |
Huang Y et al. Circ Genom Precis Med (2020)
 Reported Trait: Incident coronary artery disease OR: 1.34 [1.31, 1.36] — — Age, population stratification, smoking status, alcohol consumption, BMI, history of diabetes or hypertension, cholesterol medication use, education, Townsend deprivation index —
PPM021403 PGS004921
(CAD-GRS)
 PSS011728|
European Ancestry|
138,270 individuals
 PGP000654 |
Huang Y et al. Circ Genom Precis Med (2020)
 Reported Trait: Incident coronary artery disease OR: 1.38 [1.34, 1.41] — — Age, population stratification, smoking status, alcohol consumption, BMI, history of diabetes or hypertension, cholesterol medication use, education, Townsend deprivation index —
PPM021404 PGS004921
(CAD-GRS)
 PSS011729|
European Ancestry|
168,881 individuals
 PGP000654 |
Huang Y et al. Circ Genom Precis Med (2020)
 Reported Trait: Incident coronary artery disease OR: 1.25 [1.21, 1.3] — — Age, population stratification, smoking status, alcohol consumption, BMI, history of diabetes or hypertension, cholesterol medication use, education, Townsend deprivation index —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011727 A participant was defined as a CAD case if he/she had at least one occurrence of International Classification of Diseases, 10th edition (ICD-10) codes I21-I25 (covering ischemic heart diseases) or at least one occurrence of the following codes in Office of Population Censuses and Surveys Classification of Interventions and Procedures, version 4 (OPCS-4): K40- K46, K49, K50 or K75, which include replacement, transluminal balloon angioplasty, and other therapeutic transluminal operations on coronary artery, and percutaneous transluminal balloon angioplasty and insertion of stents. Death because of CAD was defined as an occurrence of any of the ICD-10 codes stated above as the primary cause of death. Primary incident CAD events were either captured on the earliest date of CAD event/CAD death after enrollment, or censored at the end of HES-based follow-up or at time of competing death, whichever occurred first. Those who have had CAD diagnosis before enrollment were excluded from the incident CAD analysis. 10358 CAD cases were prevalent and 9847 were incident. Median = [0.0, 8.4] years
[
  • 9,847 cases
  • , 297,304 controls
]
,
46.1 % Male samples
 Mean = 57.4 years
Sd = 8.0 years		 European — UKB —
PSS011728 A participant was defined as a CAD case if he/she had at least one occurrence of International Classification of Diseases, 10th edition (ICD-10) codes I21-I25 (covering ischemic heart diseases) or at least one occurrence of the following codes in Office of Population Censuses and Surveys Classification of Interventions and Procedures, version 4 (OPCS-4): K40- K46, K49, K50 or K75, which include replacement, transluminal balloon angioplasty, and other therapeutic transluminal operations on coronary artery, and percutaneous transluminal balloon angioplasty and insertion of stents. Death because of CAD was defined as an occurrence of any of the ICD-10 codes stated above as the primary cause of death. Primary incident CAD events were either captured on the earliest date of CAD event/CAD death after enrollment, or censored at the end of HES-based follow-up or at time of competing death, whichever occurred first. Those who have had CAD diagnosis before enrollment were excluded from the incident CAD analysis. 7976 CAD cases were prevalent and 6774 were incident. Median = [0.0, 8.4] years
[
  • 6,774 cases
  • , 131,496 controls
]
,
100.0 % Male samples
 Mean = 57.6 years
Sd = 8.1 years		 European — UKB —
PSS011729 A participant was defined as a CAD case if he/she had at least one occurrence of International Classification of Diseases, 10th edition (ICD-10) codes I21-I25 (covering ischemic heart diseases) or at least one occurrence of the following codes in Office of Population Censuses and Surveys Classification of Interventions and Procedures, version 4 (OPCS-4): K40- K46, K49, K50 or K75, which include replacement, transluminal balloon angioplasty, and other therapeutic transluminal operations on coronary artery, and percutaneous transluminal balloon angioplasty and insertion of stents. Death because of CAD was defined as an occurrence of any of the ICD-10 codes stated above as the primary cause of death. Primary incident CAD events were either captured on the earliest date of CAD event/CAD death after enrollment, or censored at the end of HES-based follow-up or at time of competing death, whichever occurred first. Those who have had CAD diagnosis before enrollment were excluded from the incident CAD analysis. 2382 CAD cases were prevalent and 3073 were incident. Median = [0.0, 8.4] years
[
  • 3,073 cases
  • , 165,808 controls
]
,
0.0 % Male samples
 Mean = 57.2 years
Sd = 7.9 years		 European — UKB —
PSS011730 A participant was defined as a CAD case if he/she had at least one occurrence of International Classification of Diseases, 10th edition (ICD-10) codes I21-I25 (covering ischemic heart diseases) or at least one occurrence of the following codes in Office of Population Censuses and Surveys Classification of Interventions and Procedures, version 4 (OPCS-4): K40- K46, K49, K50 or K75, which include replacement, transluminal balloon angioplasty, and other therapeutic transluminal operations on coronary artery, and percutaneous transluminal balloon angioplasty and insertion of stents. Death because of CAD was defined as an occurrence of any of the ICD-10 codes stated above as the primary cause of death. Primary incident CAD events were either captured on the earliest date of CAD event/CAD death after enrollment, or censored at the end of HES-based follow-up or at time of competing death, whichever occurred first. Those who have had CAD diagnosis before enrollment were excluded from the incident CAD analysis. 10358 CAD cases were prevalent and 9847 were incident. Median = [0.0, 8.4] years
[
  • 10,358 cases
  • , 307,151 controls
]
,
46.1 % Male samples
 Mean = 57.4 years
Sd = 8.0 years		 European — UKB —
PSS011731 A participant was defined as a CAD case if he/she had at least one occurrence of International Classification of Diseases, 10th edition (ICD-10) codes I21-I25 (covering ischemic heart diseases) or at least one occurrence of the following codes in Office of Population Censuses and Surveys Classification of Interventions and Procedures, version 4 (OPCS-4): K40- K46, K49, K50 or K75, which include replacement, transluminal balloon angioplasty, and other therapeutic transluminal operations on coronary artery, and percutaneous transluminal balloon angioplasty and insertion of stents. Death because of CAD was defined as an occurrence of any of the ICD-10 codes stated above as the primary cause of death. Primary incident CAD events were either captured on the earliest date of CAD event/CAD death after enrollment, or censored at the end of HES-based follow-up or at time of competing death, whichever occurred first. Those who have had CAD diagnosis before enrollment were excluded from the incident CAD analysis. 7976 CAD cases were prevalent and 6774 were incident. Median = [0.0, 8.4] years
[
  • 7,976 cases
  • , 138,270 controls
]
,
100.0 % Male samples
 Mean = 57.6 years
Sd = 8.1 years		 European — UKB —
PSS011732 A participant was defined as a CAD case if he/she had at least one occurrence of International Classification of Diseases, 10th edition (ICD-10) codes I21-I25 (covering ischemic heart diseases) or at least one occurrence of the following codes in Office of Population Censuses and Surveys Classification of Interventions and Procedures, version 4 (OPCS-4): K40- K46, K49, K50 or K75, which include replacement, transluminal balloon angioplasty, and other therapeutic transluminal operations on coronary artery, and percutaneous transluminal balloon angioplasty and insertion of stents. Death because of CAD was defined as an occurrence of any of the ICD-10 codes stated above as the primary cause of death. Primary incident CAD events were either captured on the earliest date of CAD event/CAD death after enrollment, or censored at the end of HES-based follow-up or at time of competing death, whichever occurred first. Those who have had CAD diagnosis before enrollment were excluded from the incident CAD analysis. 2382 CAD cases were prevalent and 3073 were incident. Median = [0.0, 8.4] years
[
  • 2,382 cases
  • , 168,881 controls
]
,
0.0 % Male samples
 Mean = 57.2 years
Sd = 7.9 years		 European — UKB —