Polygenic Score (PGS) ID: PGS004924

Predicted Trait
Reported Trait Parkinson's disease
Mapped Trait(s) Parkinson disease (MONDO_0005180)
Released in PGS Catalog: July 31, 2024
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Score Details

Score Construction
PGS Name PRS90_PD
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 90
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000657
Citation (link to publication) Cao Z et al. Parkinsonism Relat Disord (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
482,730 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • African
  • Not Reported
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST009325
Europe PMC: 31701892
 482,730 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021702 PSS011750|
Multi-ancestry (including European)|
3,482 individuals
 PGP000657 |
Cao Z et al. Parkinsonism Relat Disord (2023)
 Reported Trait: Parkinson's disease — — Odds ratio (OR, top vs bottom PGS quartile): 3.79 [1.64, 8.73] Age, race, 5 PCs, self-reported sense of smell, education, smoking status, self-reported health status, and PM2.5 and NO2 in 2006 —
PPM021703 PSS011751|
Multi-ancestry (including European)|
3,482 individuals
 PGP000657 |
Cao Z et al. Parkinsonism Relat Disord (2023)
 Reported Trait: Olfactory impairment (B-SIT score ≤6) — — Odds ratio (OR, top vs bottom PGS quartile): 1.42 [1.04, 1.92] Age, race, 5 PCs, self-reported sense of smell, education, smoking status, self-reported health status, and PM2.5 and NO2 in 2006 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011750 — —
[
  • 72 cases
  • , 3,410 controls
]
,
0.0 % Male samples
 — European, African unspecified, Not reported — SISTER —
PSS011751 — —
[
  • 456 cases
  • , 3,026 controls
]
,
0.0 % Male samples
 — European, African unspecified, Not reported — SISTER —