PGS Publication: PGP000657

Publication Information (EuropePMC)
Title Polygenic risk score for Parkinson's disease and olfaction among middle-aged to older women.
PubMed ID 37611509(Europe PMC)
doi 10.1016/j.parkreldis.2023.105815
Publication Date Aug. 17, 2023
Journal Parkinsonism Relat Disord
Author(s) Cao Z, Hernandez DG, Li C, Berghausen J, Luo Z, Iwaki H, D'Aloisio AA, Huang X, Pinto JM, Sandler DP, Singleton AB, Chen H.
Released in PGS Catalog: July 31, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004924
(PRS90_PD)
 PGP000657 |
Cao Z et al. Parkinsonism Relat Disord (2023)
 Parkinson's disease Parkinson disease 90
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004924/ScoringFiles/PGS004924.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021702 PGS004924
(PRS90_PD)
 PSS011750|
Multi-ancestry (including European)|
3,482 individuals
 PGP000657 |
Cao Z et al. Parkinsonism Relat Disord (2023)
 Reported Trait: Parkinson's disease — — Odds ratio (OR, top vs bottom PGS quartile): 3.79 [1.64, 8.73] Age, race, 5 PCs, self-reported sense of smell, education, smoking status, self-reported health status, and PM2.5 and NO2 in 2006 —
PPM021703 PGS004924
(PRS90_PD)
 PSS011751|
Multi-ancestry (including European)|
3,482 individuals
 PGP000657 |
Cao Z et al. Parkinsonism Relat Disord (2023)
 Reported Trait: Olfactory impairment (B-SIT score ≤6) — — Odds ratio (OR, top vs bottom PGS quartile): 1.42 [1.04, 1.92] Age, race, 5 PCs, self-reported sense of smell, education, smoking status, self-reported health status, and PM2.5 and NO2 in 2006 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011750 — —
[
  • 72 cases
  • , 3,410 controls
]
,
0.0 % Male samples
 — European, African unspecified, Not reported — SISTER —
PSS011751 — —
[
  • 456 cases
  • , 3,026 controls
]
,
0.0 % Male samples
 — European, African unspecified, Not reported — SISTER —