Polygenic Score (PGS) ID: PGS005120

Predicted Trait
Reported Trait Systolic blood pressure
Mapped Trait(s) systolic blood pressure (EFO_0006335)
Released in PGS Catalog: Feb. 4, 2025
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PGS_Teixeira_2024_SBP
Development Method
Name LDPred2 auto
Parameters NR
Variants
Original Genome Build hg19
Number of Variants 944,279
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000702
Citation (link to publication) Teixeira SK et al. Sci Rep (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
286,581 individuals (100%)
Score Development/Training
European: 100%
73,810 individuals (100%)
PGS Evaluation
Hispanic or Latin American: 66.7%
European: 33.3%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
286,581 individuals,
46.0 % Male samples
 European NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
73,810 individuals,
46.0 % Male samples
 European NR Systolic blood pressure (adjusted for medication use: +15 mmHg) — — Homogeneous European population PRS development employed LDPred2-auto, a Bayesian framework for polygenic risk scoring.

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022323 PSS011913|
Hispanic or Latin American Ancestry|
2,374 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Systolic Blood Pressure β: 2.8 [2.1, 3.5] — — Age, sex, BMI, first four genetic principal components —
PPM022324 PSS011914|
Hispanic or Latin American Ancestry|
2,904 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Systolic Blood Pressure β: 2.6 [2.2, 3.0] — — Age, sex, BMI, first four genetic principal components —
PPM022325 PSS011915|
European Ancestry|
73,790 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Systolic Blood Pressure β: 5.2 [5.1, 5.3] — — Age, sex, BMI, first four genetic principal components —
PPM022326 PSS011913|
Hispanic or Latin American Ancestry|
2,374 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Diastolic Blood Pressure β: 1.2 [0.7, 1.7] — — Age, sex, BMI, first four genetic principal components —
PPM022327 PSS011914|
Hispanic or Latin American Ancestry|
2,904 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Diastolic Blood Pressure β: 1.8 [1.4, 2.1] — — Age, sex, BMI, first four genetic principal components —
PPM022328 PSS011915|
European Ancestry|
73,790 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Diastolic Blood Pressure β: 2.1 [2.0, 2.2] — — Age, sex, BMI, first four genetic principal components —
PPM022329 PSS011913|
Hispanic or Latin American Ancestry|
2,374 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Hypertension OR: 1.28 [1.2, 1.4] AUROC: 0.79 [0.75, 0.84] — Age, sex, BMI, first four genetic principal components —
PPM022330 PSS011914|
Hispanic or Latin American Ancestry|
2,904 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Hypertension OR: 1.47 [1.3, 1.6] AUROC: 0.77 [0.74, 0.81] — Age, sex, BMI, first four genetic principal components —
PPM022331 PSS011915|
European Ancestry|
73,790 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Hypertension OR: 1.56 [1.54, 1.56] AUROC: 0.73 [0.72, 0.74] — Age, sex, BMI, first four genetic principal components —
PPM022332 PSS011913|
Hispanic or Latin American Ancestry|
2,374 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Elevated hypertension OR: 1.2 [0.5, 2.66] — — Age, sex, BMI, first four genetic principal components —
PPM022333 PSS011914|
Hispanic or Latin American Ancestry|
2,904 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Elevated hypertension OR: 1.87 [1.2, 2.8] — — Age, sex, BMI, first four genetic principal components —
PPM022335 PSS011913|
Hispanic or Latin American Ancestry|
2,374 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Stage 1 hypertension OR: 1.4 [0.77, 2.7] — — Age, sex, BMI, first four genetic principal components —
PPM022336 PSS011914|
Hispanic or Latin American Ancestry|
2,904 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Stage 1 hypertension OR: 2.14 [1.53, 3.1] — — Age, sex, BMI, first four genetic principal components —
PPM022337 PSS011915|
European Ancestry|
73,790 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Stage 1 hypertension OR: 2.52 [2.2, 2.8] — — Age, sex, BMI, first four genetic principal components —
PPM022338 PSS011913|
Hispanic or Latin American Ancestry|
2,374 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Stage 2 hypertension OR: 2.5 [1.4, 5.0] — — Age, sex, BMI, first four genetic principal components —
PPM022339 PSS011914|
Hispanic or Latin American Ancestry|
2,904 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Stage 2 hypertension OR: 2.14 [1.53, 3.1] — — Age, sex, BMI, first four genetic principal components —
PPM022340 PSS011915|
European Ancestry|
73,790 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Stage 2 hypertension OR: 4.9 [4.42, 5.56] — — Age, sex, BMI, first four genetic principal components —
PPM022334 PSS011915|
European Ancestry|
73,790 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Elevated hypertension OR: 1.8 [1.6, 2.1] — — Age, sex, BMI, first four genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011914 Systolic blood pressure (adjusted for medication use: +15 mmHg) — 2,904 individuals,
49.3 % Male samples
 — Hispanic or Latin American
(Brazilian)		 Admixed population 1982 PELOTAS Genotyping using Illumina arrays
PSS011915 Systolic blood pressure (adjusted for medication use: +15 mmHg) — 73,790 individuals,
46.0 % Male samples
 — European Homogeneous European population UKB —
PSS011913 Systolic blood pressure (adjusted for medication use: +15 mmHg) — 2,374 individuals,
42.4 % Male samples
 — Hispanic or Latin American
(Brazilian)		 Admixed population Baependi Genotyping using Affymetrix arrays