PGS Publication: PGP000702

Publication Information (EuropePMC)
Title Assessing the predictive efficacy of European-based systolic blood pressure polygenic risk scores in diverse Brazilian cohorts.
PubMed ID 39548300(Europe PMC)
doi 10.1038/s41598-024-79683-7
Publication Date Nov. 15, 2024
Journal Sci Rep
Author(s) Teixeira SK, Rossi FPN, Patane JL, Neyra JM, Jensen AVV, Horta BL, Pereira AC, Krieger JE.
Released in PGS Catalog: Feb. 4, 2025

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005120
(PGS_Teixeira_2024_SBP)
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Systolic blood pressure systolic blood pressure 944,279
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005120/ScoringFiles/PGS005120.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022323 PGS005120
(PGS_Teixeira_2024_SBP)
 PSS011913|
Hispanic or Latin American Ancestry|
2,374 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Systolic Blood Pressure β: 2.8 [2.1, 3.5] — — Age, sex, BMI, first four genetic principal components —
PPM022324 PGS005120
(PGS_Teixeira_2024_SBP)
 PSS011914|
Hispanic or Latin American Ancestry|
2,904 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Systolic Blood Pressure β: 2.6 [2.2, 3.0] — — Age, sex, BMI, first four genetic principal components —
PPM022325 PGS005120
(PGS_Teixeira_2024_SBP)
 PSS011915|
European Ancestry|
73,790 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Systolic Blood Pressure β: 5.2 [5.1, 5.3] — — Age, sex, BMI, first four genetic principal components —
PPM022326 PGS005120
(PGS_Teixeira_2024_SBP)
 PSS011913|
Hispanic or Latin American Ancestry|
2,374 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Diastolic Blood Pressure β: 1.2 [0.7, 1.7] — — Age, sex, BMI, first four genetic principal components —
PPM022327 PGS005120
(PGS_Teixeira_2024_SBP)
 PSS011914|
Hispanic or Latin American Ancestry|
2,904 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Diastolic Blood Pressure β: 1.8 [1.4, 2.1] — — Age, sex, BMI, first four genetic principal components —
PPM022328 PGS005120
(PGS_Teixeira_2024_SBP)
 PSS011915|
European Ancestry|
73,790 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Diastolic Blood Pressure β: 2.1 [2.0, 2.2] — — Age, sex, BMI, first four genetic principal components —
PPM022329 PGS005120
(PGS_Teixeira_2024_SBP)
 PSS011913|
Hispanic or Latin American Ancestry|
2,374 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Hypertension OR: 1.28 [1.2, 1.4] AUROC: 0.79 [0.75, 0.84] — Age, sex, BMI, first four genetic principal components —
PPM022330 PGS005120
(PGS_Teixeira_2024_SBP)
 PSS011914|
Hispanic or Latin American Ancestry|
2,904 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Hypertension OR: 1.47 [1.3, 1.6] AUROC: 0.77 [0.74, 0.81] — Age, sex, BMI, first four genetic principal components —
PPM022331 PGS005120
(PGS_Teixeira_2024_SBP)
 PSS011915|
European Ancestry|
73,790 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Hypertension OR: 1.56 [1.54, 1.56] AUROC: 0.73 [0.72, 0.74] — Age, sex, BMI, first four genetic principal components —
PPM022332 PGS005120
(PGS_Teixeira_2024_SBP)
 PSS011913|
Hispanic or Latin American Ancestry|
2,374 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Elevated hypertension OR: 1.2 [0.5, 2.66] — — Age, sex, BMI, first four genetic principal components —
PPM022333 PGS005120
(PGS_Teixeira_2024_SBP)
 PSS011914|
Hispanic or Latin American Ancestry|
2,904 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Elevated hypertension OR: 1.87 [1.2, 2.8] — — Age, sex, BMI, first four genetic principal components —
PPM022335 PGS005120
(PGS_Teixeira_2024_SBP)
 PSS011913|
Hispanic or Latin American Ancestry|
2,374 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Stage 1 hypertension OR: 1.4 [0.77, 2.7] — — Age, sex, BMI, first four genetic principal components —
PPM022336 PGS005120
(PGS_Teixeira_2024_SBP)
 PSS011914|
Hispanic or Latin American Ancestry|
2,904 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Stage 1 hypertension OR: 2.14 [1.53, 3.1] — — Age, sex, BMI, first four genetic principal components —
PPM022337 PGS005120
(PGS_Teixeira_2024_SBP)
 PSS011915|
European Ancestry|
73,790 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Stage 1 hypertension OR: 2.52 [2.2, 2.8] — — Age, sex, BMI, first four genetic principal components —
PPM022338 PGS005120
(PGS_Teixeira_2024_SBP)
 PSS011913|
Hispanic or Latin American Ancestry|
2,374 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Stage 2 hypertension OR: 2.5 [1.4, 5.0] — — Age, sex, BMI, first four genetic principal components —
PPM022339 PGS005120
(PGS_Teixeira_2024_SBP)
 PSS011914|
Hispanic or Latin American Ancestry|
2,904 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Stage 2 hypertension OR: 2.14 [1.53, 3.1] — — Age, sex, BMI, first four genetic principal components —
PPM022340 PGS005120
(PGS_Teixeira_2024_SBP)
 PSS011915|
European Ancestry|
73,790 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Stage 2 hypertension OR: 4.9 [4.42, 5.56] — — Age, sex, BMI, first four genetic principal components —
PPM022334 PGS005120
(PGS_Teixeira_2024_SBP)
 PSS011915|
European Ancestry|
73,790 individuals
 PGP000702 |
Teixeira SK et al. Sci Rep (2024)
 Reported Trait: Elevated hypertension OR: 1.8 [1.6, 2.1] — — Age, sex, BMI, first four genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011914 Systolic blood pressure (adjusted for medication use: +15 mmHg) — 2,904 individuals,
49.3 % Male samples
 — Hispanic or Latin American
(Brazilian)		 Admixed population 1982 PELOTAS Genotyping using Illumina arrays
PSS011915 Systolic blood pressure (adjusted for medication use: +15 mmHg) — 73,790 individuals,
46.0 % Male samples
 — European Homogeneous European population UKB —
PSS011913 Systolic blood pressure (adjusted for medication use: +15 mmHg) — 2,374 individuals,
42.4 % Male samples
 — Hispanic or Latin American
(Brazilian)		 Admixed population Baependi Genotyping using Affymetrix arrays