Trait: serum albumin measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004535
Description An albumin measurement is a quantification of albumin in blood. Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Low levels of albumin in the blood may indicate liver disease.
Trait category
Other measurement
Synonym blood albumin
Mapped term NCIt:C61015

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000669
(snpnet.Albumin)
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Albumin [g/L] serum albumin measurement 11,912
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000669/ScoringFiles/PGS000669.txt.gz - Check Terms/Licenses
PGS001886
(portability-PLR_albumin)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Albumin serum albumin measurement 60,423
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001886/ScoringFiles/PGS001886.txt.gz
PGS002099
(portability-ldpred2_albumin)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Albumin serum albumin measurement 816,264
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002099/ScoringFiles/PGS002099.txt.gz
PGS004328
(X30600.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Albumin serum albumin measurement 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004328/ScoringFiles/PGS004328.txt.gz
PGS004707
(Albumin_PRSmix_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Albumin serum albumin measurement 589,303
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004707/ScoringFiles/PGS004707.txt.gz
PGS004708
(Albumin_PRSmix_sas)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Albumin serum albumin measurement 2,071,924
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004708/ScoringFiles/PGS004708.txt.gz
PGS004709
(Albumin_PRSmixPlus_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Albumin serum albumin measurement 2,659,200
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004709/ScoringFiles/PGS004709.txt.gz
PGS004710
(Albumin_PRSmixPlus_sas)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Albumin serum albumin measurement 2,071,924
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004710/ScoringFiles/PGS004710.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001397 PGS000669
(snpnet.Albumin)
 PSS000627|
African Ancestry|
5,573 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Albumin [g/L] — — R²: 0.10081
Spearman's ρ: 0.121		 Age, sex, PCs(1-40) —
PPM001432 PGS000669
(snpnet.Albumin)
 PSS000628|
East Asian Ancestry|
984 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Albumin [g/L] — — R²: 0.08916
Spearman's ρ: 0.198		 Age, sex, PCs(1-40) —
PPM001467 PGS000669
(snpnet.Albumin)
 PSS000629|
European Ancestry|
21,516 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Albumin [g/L] — — R²: 0.13257
Spearman's ρ: 0.25		 Age, sex, PCs(1-40) —
PPM001502 PGS000669
(snpnet.Albumin)
 PSS000630|
South Asian Ancestry|
6,687 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Albumin [g/L] — — R²: 0.15158
Spearman's ρ: 0.216		 Age, sex, PCs(1-40) —
PPM001537 PGS000669
(snpnet.Albumin)
 PSS000631|
European Ancestry|
58,196 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Albumin [g/L] — — R²: 0.13054
Spearman's ρ: 0.262		 Age, sex, PCs(1-40) —
PPM007271 PGS000669
(snpnet.Albumin)
 PSS007067|
East Asian Ancestry|
1,472 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Albumin — — R²: 0.02049 [0.0072, 0.03378]
Incremental R2 (full-covars): 0.00193
PGS R2 (no covariates): 0.05108 [0.03075, 0.0714]		 age, sex, UKB array type, Genotype PCs —
PPM007274 PGS000669
(snpnet.Albumin)
 PSS007070|
European Ancestry|
59,097 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Albumin — — R²: 0.03793 [0.0351, 0.04076]
Incremental R2 (full-covars): 0.00267
PGS R2 (no covariates): 0.06779 [0.06413, 0.07145]		 age, sex, UKB array type, Genotype PCs —
PPM007270 PGS000669
(snpnet.Albumin)
 PSS007066|
African Ancestry|
5,658 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Albumin — — R²: 0.07255 [0.06041, 0.08469]
Incremental R2 (full-covars): 0.00087
PGS R2 (no covariates): 0.01339 [0.00784, 0.01894]		 age, sex, UKB array type, Genotype PCs —
PPM007272 PGS000669
(snpnet.Albumin)
 PSS007068|
European Ancestry|
21,759 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Albumin — — R²: 0.04362 [0.03866, 0.04859]
Incremental R2 (full-covars): 0.00252
PGS R2 (no covariates): 0.0618 [0.05601, 0.06759]		 age, sex, UKB array type, Genotype PCs —
PPM007273 PGS000669
(snpnet.Albumin)
 PSS007069|
South Asian Ancestry|
6,786 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Albumin — — R²: 0.0904 [0.07829, 0.10251]
Incremental R2 (full-covars): 0.00198
PGS R2 (no covariates): 0.04739 [0.03821, 0.05657]		 age, sex, UKB array type, Genotype PCs —
PPM009972 PGS001886
(portability-PLR_albumin)
 PSS009382|
European Ancestry|
17,457 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.2949 [0.2813, 0.3084] sex, age, birth date, deprivation index, 16 PCs —
PPM009973 PGS001886
(portability-PLR_albumin)
 PSS009156|
European Ancestry|
3,593 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.2758 [0.2452, 0.3058] sex, age, birth date, deprivation index, 16 PCs —
PPM009974 PGS001886
(portability-PLR_albumin)
 PSS008710|
European Ancestry|
5,803 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.2722 [0.2482, 0.2959] sex, age, birth date, deprivation index, 16 PCs —
PPM009975 PGS001886
(portability-PLR_albumin)
 PSS008484|
Greater Middle Eastern Ancestry|
1,036 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.2704 [0.2124, 0.3264] sex, age, birth date, deprivation index, 16 PCs —
PPM009976 PGS001886
(portability-PLR_albumin)
 PSS008262|
South Asian Ancestry|
5,478 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.2714 [0.2467, 0.2958] sex, age, birth date, deprivation index, 16 PCs —
PPM009977 PGS001886
(portability-PLR_albumin)
 PSS008040|
East Asian Ancestry|
1,560 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.226 [0.178, 0.2729] sex, age, birth date, deprivation index, 16 PCs —
PPM009978 PGS001886
(portability-PLR_albumin)
 PSS007826|
African Ancestry|
2,159 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.1475 [0.1058, 0.1887] sex, age, birth date, deprivation index, 16 PCs —
PPM009979 PGS001886
(portability-PLR_albumin)
 PSS008930|
African Ancestry|
3,401 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.1407 [0.1075, 0.1736] sex, age, birth date, deprivation index, 16 PCs —
PPM011648 PGS002099
(portability-ldpred2_albumin)
 PSS009382|
European Ancestry|
17,457 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.289 [0.2754, 0.3026] sex, age, birth date, deprivation index, 16 PCs —
PPM011649 PGS002099
(portability-ldpred2_albumin)
 PSS009156|
European Ancestry|
3,593 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.2771 [0.2465, 0.3071] sex, age, birth date, deprivation index, 16 PCs —
PPM011650 PGS002099
(portability-ldpred2_albumin)
 PSS008710|
European Ancestry|
5,803 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.2717 [0.2476, 0.2954] sex, age, birth date, deprivation index, 16 PCs —
PPM011651 PGS002099
(portability-ldpred2_albumin)
 PSS008484|
Greater Middle Eastern Ancestry|
1,036 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.2567 [0.1983, 0.3132] sex, age, birth date, deprivation index, 16 PCs —
PPM011652 PGS002099
(portability-ldpred2_albumin)
 PSS008262|
South Asian Ancestry|
5,478 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.265 [0.2402, 0.2895] sex, age, birth date, deprivation index, 16 PCs —
PPM011653 PGS002099
(portability-ldpred2_albumin)
 PSS008040|
East Asian Ancestry|
1,560 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.2305 [0.1827, 0.2773] sex, age, birth date, deprivation index, 16 PCs —
PPM011654 PGS002099
(portability-ldpred2_albumin)
 PSS007826|
African Ancestry|
2,159 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.1481 [0.1063, 0.1893] sex, age, birth date, deprivation index, 16 PCs —
PPM011655 PGS002099
(portability-ldpred2_albumin)
 PSS008930|
African Ancestry|
3,401 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.1569 [0.1238, 0.1896] sex, age, birth date, deprivation index, 16 PCs —
PPM020443 PGS004328
(X30600.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Albumin — — PGS R2 (no covariates): 0.18905 — —
PPM020932 PGS004707
(Albumin_PRSmix_eur)
 PSS011480|
European Ancestry|
4,879 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Albumin — — Incremental R2 (Full model versus model with only covariates): 0.029 [0.019, 0.038] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)
PPM020933 PGS004708
(Albumin_PRSmix_sas)
 PSS011460|
South Asian Ancestry|
6,864 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Albumin — — Incremental R2 (Full model versus model with only covariates): 0.029 [0.021, 0.037] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)
PPM020934 PGS004709
(Albumin_PRSmixPlus_eur)
 PSS011480|
European Ancestry|
4,879 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Albumin — — Incremental R2 (Full model versus model with only covariates): 0.042 [0.031, 0.053] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)
PPM020935 PGS004710
(Albumin_PRSmixPlus_sas)
 PSS011460|
South Asian Ancestry|
6,864 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Albumin — — Incremental R2 (Full model versus model with only covariates): 0.033 [0.025, 0.041] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009156 — — 3,593 individuals — European Poland (NE Europe) UKB —
PSS008262 — — 5,478 individuals — South Asian India (South Asia) UKB —
PSS011460 — — 6,864 individuals — South Asian — G&H —
PSS008930 — — 3,401 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008040 — — 1,560 individuals — East Asian China (East Asia) UKB —
PSS011480 — — 4,879 individuals — European — AllofUs —
PSS008710 — — 5,803 individuals — European Italy (South Europe) UKB —
PSS000627 — — 5,573 individuals — African unspecified — UKB —
PSS000628 — — 984 individuals — East Asian — UKB —
PSS000629 — — 21,516 individuals — European Non-British White UKB —
PSS000630 — — 6,687 individuals — South Asian — UKB —
PSS000631 — — 58,196 individuals — European
(British)		 — UKB —
PSS007826 — — 2,159 individuals — African American or Afro-Caribbean Carribean UKB —
PSS011364 — — 56,192 individuals — European — UKB —
PSS007066 — — 5,658 individuals — African unspecified — UKB —
PSS007067 — — 1,472 individuals — East Asian — UKB —
PSS007068 — — 21,759 individuals — European non-white British ancestry UKB —
PSS007069 — — 6,786 individuals — South Asian — UKB —
PSS007070 — — 59,097 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS009382 — — 17,457 individuals — European UK (+ Ireland) UKB —
PSS008484 — — 1,036 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —