Trait: thyroid stimulating hormone measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004748
Description Is a quantification of thyroid-stimulating hormone, a glycoprotein and hormone secreted from the pituitary which regulates the thryoid.
Trait category
Other measurement
Synonyms 3 synonyms
  • thyroid stimulating hormone level
  • thyroid stimulating hormone levels
  • thyrotropin measurement
Mapped terms 2 mapped terms
  • NCIt:C64813
  • SNOMEDCT:61167004

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (excluding European)
African
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Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004906
(PRS60_TSH)
 PGP000639 |
Mulder TA et al. Eur J Endocrinol (2023)
 Thyroid stimulating hormone concentration thyroid stimulating hormone measurement 60
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004906/ScoringFiles/PGS004906.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021356 PGS004906
(PRS60_TSH)
 PSS011701|
European Ancestry|
7,231 individuals
 PGP000639 |
Mulder TA et al. Eur J Endocrinol (2023)
 Reported Trait: Thyroid stimulating hormone concentration β: 0.16 (0.01) — — — —
PPM021357 PGS004906
(PRS60_TSH)
 PSS011701|
European Ancestry|
7,231 individuals
 PGP000639 |
Mulder TA et al. Eur J Endocrinol (2023)
 Reported Trait: Free thyroxine (FT4) concentration β: -0.04 (0.01) — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011701 — — 1,680 individuals,
49.3 % Male samples
 Median = 12.1 years
95% Range = [12.0, 12.5] years		 European — BLTS —
PSS011701 — — 2,169 individuals,
50.8 % Male samples
 Median = 6.0 years
95% Range = [5.7, 7.5] years		 European — Generation_R —
PSS011701 — — 3,382 individuals,
52.0 % Male samples
 Median = 7.5 years
95% Range = [7.3, 8.9] years		 European — ALSPAC —