Trait: adipose tissue measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004764
Description Is a quantification of some aspect of adipose tissue, for example used in the diagnosis and research into obesity.
Trait category
Other measurement
Child trait(s) visceral adipose tissue measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "adipose tissue measurement" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000844
(VAT_Mass)
 PGP000211 |
Aly DM et al. Nat Genet (2021)
 Predicted visceral adipose tissue visceral adipose tissue measurement 518
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000844/ScoringFiles/PGS000844.txt.gz
PGS002811
(ASATadjbmi3_weights_select)
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Abdominal adipose tissue volumes adjusted for BMI and height adipose tissue measurement 1,125,301
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002811/ScoringFiles/PGS002811.txt.gz
PGS002812
(GFATadjbmi3_weights_select)
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Gluteofemoral adipose tissue volumes adjusted for BMI and height adipose tissue measurement 1,125,301
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002812/ScoringFiles/PGS002812.txt.gz
PGS002813
(VATadjbmi3_weights_select)
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Visceral adipose tissue volumes adjusted for BMI and height visceral adipose tissue measurement 1,125,301
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002813/ScoringFiles/PGS002813.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002303 PGS000844
(VAT_Mass)
 PSS001086|
European Ancestry|
3,194 individuals
 PGP000211 |
Aly DM et al. Nat Genet (2021)
 Reported Trait: Severe Autoimmune Diabetes OR: 1.17 [1.06, 1.29] — — PC1-10 —
PPM002305 PGS000844
(VAT_Mass)
 PSS001088|
European Ancestry|
3,869 individuals
 PGP000211 |
Aly DM et al. Nat Genet (2021)
 Reported Trait: Severe Insulin-Resistant Diabetes OR: 1.26 [1.18, 1.36] — — PC1-10 —
PPM002306 PGS000844
(VAT_Mass)
 PSS001085|
European Ancestry|
4,116 individuals
 PGP000211 |
Aly DM et al. Nat Genet (2021)
 Reported Trait: Moderate Obesity-related Diabetes OR: 1.49 [1.39, 1.6] — — PC1-10 —
PPM002307 PGS000844
(VAT_Mass)
 PSS001084|
European Ancestry|
5,597 individuals
 PGP000211 |
Aly DM et al. Nat Genet (2021)
 Reported Trait: Moderate Age-Related Diabetes OR: 1.1 [1.04, 1.16] — — PC1-10 —
PPM002304 PGS000844
(VAT_Mass)
 PSS001087|
European Ancestry|
3,930 individuals
 PGP000211 |
Aly DM et al. Nat Genet (2021)
 Reported Trait: Severe Insulin-Deficient Diabetes OR: 1.27 [1.18, 1.36] — — PC1-10 —
PPM020182 PGS000844
(VAT_Mass)
 PSS011301|
South Asian Ancestry|
1,282 individuals
 PGP000525 |
Yajnik CS et al. Lancet Reg Health Southeast Asia (2023)
|Ext.		 Reported Trait: BMI β: 0.14774 (0.027271) — — — —
PPM015587 PGS002811
(ASATadjbmi3_weights_select)
 PSS009993|
Multi-ancestry (including European)|
7,795 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Abdominal adipose tissue volumes adjusted for BMI and height β: 0.195 (0.016) — Odds ratio (OR, top 5% vs reminder): 2.13 [1.46, 3.03] Age at time of imaging, sex, and the first 10 PCs of genetic ancestry —
PPM015589 PGS002811
(ASATadjbmi3_weights_select)
 PSS009992|
European Ancestry|
7,888 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: HDL cholesterol — — Beta (top 10 % vs reminder): 0.09 [0.02, 0.17] Age at enrollment, sex, and the first 10 principal components of genetic ancestry —
PPM015588 PGS002812
(GFATadjbmi3_weights_select)
 PSS009993|
Multi-ancestry (including European)|
7,795 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Gluteofemoral adipose tissue volumes adjusted for BMI and height β: 0.262 (0.016) — Odds ratio (OR, top 5% vs reminder): 3.81 [2.76, 5.17] Age at time of imaging, sex, and the first 10 PCs of genetic ancestry —
PPM015590 PGS002812
(GFATadjbmi3_weights_select)
 PSS009992|
European Ancestry|
7,888 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: HDL cholesterol — — Beta (top 10 % vs reminder): 0.14 [0.07, 0.22] Age at enrollment, sex, and the first 10 principal components of genetic ancestry —
PPM015591 PGS002812
(GFATadjbmi3_weights_select)
 PSS009992|
European Ancestry|
7,888 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Triglycerides — — Beta (top 10 % vs reminder): -0.16 [-0.23, -0.08] Age at enrollment, sex, and the first 10 principal components of genetic ancestry —
PPM015593 PGS002812
(GFATadjbmi3_weights_select)
 PSS009992|
European Ancestry|
7,888 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Type 2 Diabetes — — Odds ratio (OR, top 10% vs reminder): 0.57 [0.41, 0.78] Age at enrollment, sex, and the first 10 principal components of genetic ancestry —
PPM015594 PGS002812
(GFATadjbmi3_weights_select)
 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: HDL cholesterol — — Beta (top 10 % vs reminder): 0.16 [0.15, 0.18] — —
PPM015595 PGS002812
(GFATadjbmi3_weights_select)
 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Triglycerides — — Beta (top 10 % vs reminder): -0.16 [-0.18, -0.15] — —
PPM015596 PGS002812
(GFATadjbmi3_weights_select)
 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Alanine aminotransferase — — Beta (top 10 % vs reminder): -0.09 [-0.1, -0.07] — —
PPM015597 PGS002812
(GFATadjbmi3_weights_select)
 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Type 2 Diabetes — — Odds ratio (OR, top 10% vs reminder): 0.75 [0.7, 0.8] — —
PPM015598 PGS002812
(GFATadjbmi3_weights_select)
 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Coronary artery disease — — Odds ratio (OR, top 10% vs reminder): 0.89 [0.85, 0.93] — —
PPM015599 PGS002813
(VATadjbmi3_weights_select)
 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Type 2 Diabetes — — Odds ratio (OR, top 10% vs reminder): 1.18 — —
PPM015600 PGS002813
(VATadjbmi3_weights_select)
 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Coronary artery disease — — Odds ratio (OR, top 10% vs reminder): 1.12 — —
PPM015601 PGS002813
(VATadjbmi3_weights_select)
 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Hypertension — — Odds ratio (OR, top 10% vs reminder): 1.09 — —
PPM015586 PGS002813
(VATadjbmi3_weights_select)
 PSS009993|
Multi-ancestry (including European)|
7,795 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Visceral adipose tissue volumes adjusted for BMI and height β: 0.221 (0.016) — Odds ratio (OR, top 5% vs reminder): 2.41 [1.7, 3.36] Age at time of imaging, sex, and the first 10 PCs of genetic ancestry —
PPM015592 PGS002813
(VATadjbmi3_weights_select)
 PSS009992|
European Ancestry|
7,888 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Triglycerides — — Beta (bottom 10 % vs reminder): -0.12 [-0.19, -0.05] Age at enrollment, sex, and the first 10 principal components of genetic ancestry —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011301 — —
[
  • 821 cases
  • , 461 controls
]
 — South Asian
(Indian)		 — WellGen —
PSS009992 — — 7,888 individuals — European
(White)		 — ARIC —
PSS009993 — — 7,795 individuals — European, African unspecified, East Asian, South Asian, Not reported White British, Black, East Asian, South Asian, Other UKB 20% of original GWAS cohort
PSS009994 — — 447,486 individuals — European, African unspecified, East Asian, South Asian, Not reported White British, Black, East Asian, South Asian, Other UKB Unimaged cohort of UKB
PSS001084 Moderate Age-Related Diabetes (MARD) vs. controls —
[
  • 2,853 cases
  • , 2,744 controls
]
 — European Swedish ANDIS —
PSS001085 Moderate Obesity-related Diabetes (MOD) vs. controls —
[
  • 1,372 cases
  • , 2,744 controls
]
 — European Swedish ANDIS —
PSS001086 Severe Autoimmune Diabetes (SAID) vs. controls —
[
  • 450 cases
  • , 2,744 controls
]
 — European Swedish ANDIS —
PSS001087 Severe Insulin-Deficient Diabetes (SIDD) vs. controls —
[
  • 1,186 cases
  • , 2,744 controls
]
 — European Swedish ANDIS —
PSS001088 Severe Insulin-Resistant Diabetes (SIRD) vs. controls —
[
  • 1,125 cases
  • , 2,744 controls
]
 — European Swedish ANDIS —