Trait: non-high density lipoprotein cholesterol measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0005689
Description The quantification of NHDL cholesterol in blood, calculated by subtracting the amount of cholesterol in the HDL fraction from total cholesterol and used as an indicator for cardiovascular disease risk
Trait categories
Cardiovascular measurement
Lipid or lipoprotein measurement
Synonym NHDL cholesterol measurement
Mapped term NCIt:C116204

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002782
(GLGC_2021_ALL_nonHDL_PRS_weights_PRS-CS)
 PGP000366 |
Kanoni S et al. Genome Biol (2022)
 nonHDL Cholesterol non-high density lipoprotein cholesterol measurement 1,239,184
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002782/ScoringFiles/PGS002782.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016162 PGS002782
(GLGC_2021_ALL_nonHDL_PRS_weights_PRS-CS)
 PSS010052|
Multi-ancestry (including European)|
461,918 individuals
 PGP000366 |
Kanoni S et al. Genome Biol (2022)
 Reported Trait: Baseline nonHDL cholesterol — — R²: 0.14 sex, batch, age at initial assessment, PCs1-4 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010052 — — 461,918 individuals — European, African unspecified, East Asian, South Asian — UKB —