Trait: cerebrospinal fluid volume measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0008080
Description quantification of the volume of cerebrospinal fluid in the brain, usually through an MRI scan
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001070
(GBE_INI25003)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Volume of ventricular cerebrospinal fluid (normalised for head size) cerebrospinal fluid volume measurement 880
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001070/ScoringFiles/PGS001070.txt.gz
PGS001639
(GBE_INI25004)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Volume of ventricular cerebrospinal fluid neuroimaging measurement,
cerebrospinal fluid volume measurement		 772
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001639/ScoringFiles/PGS001639.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008108 PGS001070
(GBE_INI25003)
 PSS005196|
African Ancestry|
200 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of ventricular cerebrospinal fluid (normalised for head size) — — R²: 0.29254 [0.27395, 0.31114]
Incremental R2 (full-covars): 0.01574
PGS R2 (no covariates): 0.00903 [0.00446, 0.01361]		 age, sex, UKB array type, Genotype PCs —
PPM008109 PGS001070
(GBE_INI25003)
 PSS005197|
East Asian Ancestry|
113 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of ventricular cerebrospinal fluid (normalised for head size) — — R²: 0.3397 [0.30323, 0.37618]
Incremental R2 (full-covars): 0.00796
PGS R2 (no covariates): 0.01224 [0.00189, 0.0226]		 age, sex, UKB array type, Genotype PCs —
PPM008110 PGS001070
(GBE_INI25003)
 PSS005198|
European Ancestry|
1,739 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of ventricular cerebrospinal fluid (normalised for head size) — — R²: 0.2568 [0.24745, 0.26615]
Incremental R2 (full-covars): 0.01559
PGS R2 (no covariates): 0.0141 [0.01119, 0.01701]		 age, sex, UKB array type, Genotype PCs —
PPM008111 PGS001070
(GBE_INI25003)
 PSS005199|
South Asian Ancestry|
329 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of ventricular cerebrospinal fluid (normalised for head size) — — R²: 0.39225 [0.3754, 0.4091]
Incremental R2 (full-covars): 0.00541
PGS R2 (no covariates): 0.00534 [0.00212, 0.00856]		 age, sex, UKB array type, Genotype PCs —
PPM008112 PGS001070
(GBE_INI25003)
 PSS005200|
European Ancestry|
5,445 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of ventricular cerebrospinal fluid (normalised for head size) — — R²: 0.25764 [0.25195, 0.26333]
Incremental R2 (full-covars): 0.01868
PGS R2 (no covariates): 0.01638 [0.01448, 0.01828]		 age, sex, UKB array type, Genotype PCs —
PPM005365 PGS001639
(GBE_INI25004)
 PSS005201|
African Ancestry|
200 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of ventricular cerebrospinal fluid — — R²: 0.32375 [0.30505, 0.34246]
Incremental R2 (full-covars): 0.01105
PGS R2 (no covariates): 0.00559 [0.00198, 0.00921]		 age, sex, UKB array type, Genotype PCs —
PPM005366 PGS001639
(GBE_INI25004)
 PSS005202|
East Asian Ancestry|
113 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of ventricular cerebrospinal fluid — — R²: 0.349 [0.31255, 0.38544]
Incremental R2 (full-covars): 0.01036
PGS R2 (no covariates): 0.00796 [-0.00043, 0.01635]		 age, sex, UKB array type, Genotype PCs —
PPM005367 PGS001639
(GBE_INI25004)
 PSS005203|
European Ancestry|
1,739 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of ventricular cerebrospinal fluid — — R²: 0.28228 [0.27281, 0.29175]
Incremental R2 (full-covars): 0.01775
PGS R2 (no covariates): 0.01813 [0.01485, 0.02141]		 age, sex, UKB array type, Genotype PCs —
PPM005368 PGS001639
(GBE_INI25004)
 PSS005204|
South Asian Ancestry|
329 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of ventricular cerebrospinal fluid — — R²: 0.36613 [0.34915, 0.38311]
Incremental R2 (full-covars): 0.00516
PGS R2 (no covariates): 0.00707 [0.00337, 0.01077]		 age, sex, UKB array type, Genotype PCs —
PPM005369 PGS001639
(GBE_INI25004)
 PSS005205|
European Ancestry|
5,445 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of ventricular cerebrospinal fluid — — R²: 0.28661 [0.28085, 0.29238]
Incremental R2 (full-covars): 0.01665
PGS R2 (no covariates): 0.01482 [0.01301, 0.01663]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS005196 — — 200 individuals — African unspecified — UKB —
PSS005197 — — 113 individuals — East Asian — UKB —
PSS005198 — — 1,739 individuals — European non-white British ancestry UKB —
PSS005199 — — 329 individuals — South Asian — UKB —
PSS005200 — — 5,445 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS005201 — — 200 individuals — African unspecified — UKB —
PSS005202 — — 113 individuals — East Asian — UKB —
PSS005203 — — 1,739 individuals — European non-white British ancestry UKB —
PSS005204 — — 329 individuals — South Asian — UKB —
PSS005205 — — 5,445 individuals — European white British ancestry UKB Testing cohort (heldout set)