Trait: anxiety measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009863
Description Quantification of the level of a generalised feeling of anxiety experienced by an individual, typically measured via a questionnaire.
Trait category
Other measurement
Mapped term PMID:30867560

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001021
(GBE_BIN1980)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Feelings of worry or anxiety worry measurement,
anxiety measurement		 9,747
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001021/ScoringFiles/PGS001021.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007868 PGS001021
(GBE_BIN1980)
 PSS003642|
African Ancestry|
6,104 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worrier / anxious feelings — AUROC: 0.60438 [0.59021, 0.61855] R²: 0.04352
Incremental AUROC (full-covars): -0.00571
PGS R2 (no covariates): 0.00129
PGS AUROC (no covariates): 0.51656 [0.50201, 0.53111]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007869 PGS001021
(GBE_BIN1980)
 PSS003643|
East Asian Ancestry|
1,544 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worrier / anxious feelings — AUROC: 0.58907 [0.5608, 0.61733] R²: 0.03544
Incremental AUROC (full-covars): 0.01078
PGS R2 (no covariates): 0.0074
PGS AUROC (no covariates): 0.54082 [0.51208, 0.56956]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007870 PGS001021
(GBE_BIN1980)
 PSS003644|
European Ancestry|
24,170 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worrier / anxious feelings — AUROC: 0.6078 [0.60064, 0.61496] R²: 0.04664
Incremental AUROC (full-covars): 0.01418
PGS R2 (no covariates): 0.01254
PGS AUROC (no covariates): 0.55518 [0.54786, 0.56249]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007871 PGS001021
(GBE_BIN1980)
 PSS003645|
South Asian Ancestry|
7,170 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worrier / anxious feelings — AUROC: 0.59978 [0.58669, 0.61287] R²: 0.03875
Incremental AUROC (full-covars): -0.00373
PGS R2 (no covariates): 0.00244
PGS AUROC (no covariates): 0.5253 [0.51187, 0.53873]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007872 PGS001021
(GBE_BIN1980)
 PSS003646|
European Ancestry|
65,798 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Worrier / anxious feelings — AUROC: 0.6164 [0.61209, 0.62072] R²: 0.05295
Incremental AUROC (full-covars): 0.0259
PGS R2 (no covariates): 0.01465
PGS AUROC (no covariates): 0.55972 [0.5553, 0.56414]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS003644 — —
[
  • 13,973 cases
  • , 10,197 controls
]
 — European non-white British ancestry UKB —
PSS003645 — —
[
  • 3,970 cases
  • , 3,200 controls
]
 — South Asian — UKB —
PSS003646 — —
[
  • 37,860 cases
  • , 27,938 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS003642 — —
[
  • 2,702 cases
  • , 3,402 controls
]
 — African unspecified — UKB —
PSS003643 — —
[
  • 746 cases
  • , 798 controls
]
 — East Asian — UKB —