Trait: blood immunoglobulin amount

Trait Information
Identifier OBA_VT0002460
Description The amount of a immunoglobulin complex. [AUTO: patterns/patterns/entity_attribute]
Trait category
Other measurement
Synonym amount of immunoglobulin complex
Child trait(s) serum IgE amount

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "blood immunoglobulin amount" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000315
(GRS7_lgE)
 PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
 Immunoglobulin E (IgE) serum IgE amount 7
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000315/ScoringFiles/PGS000315.txt.gz
PGS001772
(GBE_INI23005)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 ZEBRA antigen for Epstein-Barr Virus blood immunoglobulin amount 158
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001772/ScoringFiles/PGS001772.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000785 PGS000315
(GRS7_lgE)
 PSS000376|
European Ancestry|
1,354 individuals
 PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
 Reported Trait: Immunoglobulin E (kU/I) — — R²: 0.0206 Sex, age —
PPM005340 PGS001772
(GBE_INI23005)
 PSS005016|
African Ancestry|
119 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: ZEBRA antigen for Epstein-Barr Virus — — R²: 0.13241 [0.11706, 0.14775]
Incremental R2 (full-covars): 0.0307
PGS R2 (no covariates): 0.04734 [0.03727, 0.05742]		 age, sex, UKB array type, Genotype PCs —
PPM005341 PGS001772
(GBE_INI23005)
 PSS005017|
East Asian Ancestry|
41 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: ZEBRA antigen for Epstein-Barr Virus — — R²: 0.42791 [0.39244, 0.46337]
Incremental R2 (full-covars): 0.00179
PGS R2 (no covariates): 0.02952 [0.01372, 0.04533]		 age, sex, UKB array type, Genotype PCs —
PPM005342 PGS001772
(GBE_INI23005)
 PSS005018|
European Ancestry|
471 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: ZEBRA antigen for Epstein-Barr Virus — — R²: 0.07688 [0.07052, 0.08324]
Incremental R2 (full-covars): 0.02635
PGS R2 (no covariates): 0.02765 [0.02363, 0.03166]		 age, sex, UKB array type, Genotype PCs —
PPM005343 PGS001772
(GBE_INI23005)
 PSS005019|
South Asian Ancestry|
164 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: ZEBRA antigen for Epstein-Barr Virus — — R²: 0.15445 [0.13974, 0.16917]
Incremental R2 (full-covars): -0.01516
PGS R2 (no covariates): 0.00397 [0.00119, 0.00675]		 age, sex, UKB array type, Genotype PCs —
PPM005344 PGS001772
(GBE_INI23005)
 PSS005020|
European Ancestry|
1,275 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: ZEBRA antigen for Epstein-Barr Virus — — R²: 0.05788 [0.05445, 0.0613]
Incremental R2 (full-covars): 0.03995
PGS R2 (no covariates): 0.03909 [0.03622, 0.04196]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS005020 — — 1,275 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS000376 We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). — 1,354 individuals,
47.56 % Male samples
 Mean = 16.22 years
Sd = 0.66 years		 European — TRAILS —
PSS005016 — — 119 individuals — African unspecified — UKB —
PSS005017 — — 41 individuals — East Asian — UKB —
PSS005018 — — 471 individuals — European non-white British ancestry UKB —
PSS005019 — — 164 individuals — South Asian — UKB —