Trait Information | |
Identifier | OBA_VT0002460 |
Description | The amount of a immunoglobulin complex. [AUTO: patterns/patterns/entity_attribute] | Trait category |
Other trait
|
Synonym | amount of immunoglobulin complex |
Child trait(s) | serum IgE amount |
Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
---|---|---|---|---|---|---|
PGS000315 (GRS7_lgE) |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Immunoglobulin E (IgE) | serum IgE amount | 7 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000315/ScoringFiles/PGS000315.txt.gz |
PGS001772 (GBE_INI23005) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
ZEBRA antigen for Epstein-Barr Virus | blood immunoglobulin amount | 158 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001772/ScoringFiles/PGS001772.txt.gz |
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM000785 | PGS000315 (GRS7_lgE) |
PSS000376| European Ancestry| 1,354 individuals |
PGP000092 | Xie T et al. Circ Genom Precis Med (2020) |
Reported Trait: Immunoglobulin E (kU/I) | — | — | R²: 0.0206 | Sex, age | — |
PPM005340 | PGS001772 (GBE_INI23005) |
PSS005016| African Ancestry| 119 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: ZEBRA antigen for Epstein-Barr Virus | — | — | R²: 0.13241 [0.11706, 0.14775] Incremental R2 (full-covars): 0.0307 PGS R2 (no covariates): 0.04734 [0.03727, 0.05742] |
age, sex, UKB array type, Genotype PCs | — |
PPM005341 | PGS001772 (GBE_INI23005) |
PSS005017| East Asian Ancestry| 41 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: ZEBRA antigen for Epstein-Barr Virus | — | — | R²: 0.42791 [0.39244, 0.46337] Incremental R2 (full-covars): 0.00179 PGS R2 (no covariates): 0.02952 [0.01372, 0.04533] |
age, sex, UKB array type, Genotype PCs | — |
PPM005342 | PGS001772 (GBE_INI23005) |
PSS005018| European Ancestry| 471 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: ZEBRA antigen for Epstein-Barr Virus | — | — | R²: 0.07688 [0.07052, 0.08324] Incremental R2 (full-covars): 0.02635 PGS R2 (no covariates): 0.02765 [0.02363, 0.03166] |
age, sex, UKB array type, Genotype PCs | — |
PPM005343 | PGS001772 (GBE_INI23005) |
PSS005019| South Asian Ancestry| 164 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: ZEBRA antigen for Epstein-Barr Virus | — | — | R²: 0.15445 [0.13974, 0.16917] Incremental R2 (full-covars): -0.01516 PGS R2 (no covariates): 0.00397 [0.00119, 0.00675] |
age, sex, UKB array type, Genotype PCs | — |
PPM005344 | PGS001772 (GBE_INI23005) |
PSS005020| European Ancestry| 1,275 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: ZEBRA antigen for Epstein-Barr Virus | — | — | R²: 0.05788 [0.05445, 0.0613] Incremental R2 (full-covars): 0.03995 PGS R2 (no covariates): 0.03909 [0.03622, 0.04196] |
age, sex, UKB array type, Genotype PCs | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS005020 | — | — | 1,275 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |
PSS000376 | We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). | — | 1,354 individuals, 47.56 % Male samples |
Mean = 16.22 years Sd = 0.66 years |
European | — | TRAILS | — |
PSS005016 | — | — | 119 individuals | — | African unspecified | — | UKB | — |
PSS005017 | — | — | 41 individuals | — | East Asian | — | UKB | — |
PSS005018 | — | — | 471 individuals | — | European | non-white British ancestry | UKB | — |
PSS005019 | — | — | 164 individuals | — | South Asian | — | UKB | — |