PGS Publication: PGP000317

Publication Information (EuropePMC)
Title Association of Polygenic Risk Score With Blood Pressure and Adverse Cardiovascular Outcomes in Individuals With Type II Diabetes: Insights From the ACCORD Trial.
PubMed ID 35369713(Europe PMC)
doi 10.1161/hypertensionaha.122.18976
Publication Date April 4, 2022
Journal Hypertension
Author(s) Parcha V, Pampana A, Bress AP, Irvin MR, Arora G, Arora P.
Released in PGS Catalog: May 18, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002257
(GRS901_SBP)
 PGP000283 |
Evangelou E et al. Nat Genet (2018)
 Systolic blood pressure systolic blood pressure 884
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002257/ScoringFiles/PGS002257.txt.gz
PGS002258
(GRS901_DBP)
 PGP000283 |
Evangelou E et al. Nat Genet (2018)
 Diastolic blood pressure diastolic blood pressure 885
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002258/ScoringFiles/PGS002258.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013002 PGS002257
(GRS901_SBP)
 PSS009643|
Ancestry Not Reported|
6,335 individuals
 PGP000317 |
Parcha V et al. Hypertension (2022)
|Ext.		 Reported Trait: Diastolic blood pressure β: 0.65 — — PGS002258, age, age^2, sex, BMI, randomization arm, history of CVD event, serum creatinine, fasting blood glucose, LDL levels, 10 genetic PCs *NOTE*: PGS is calculated as an average of PGS002257 and PGS002258
PPM013003 PGS002257
(GRS901_SBP)
 PSS009643|
Ancestry Not Reported|
6,335 individuals
 PGP000317 |
Parcha V et al. Hypertension (2022)
|Ext.		 Reported Trait: Adverse cardiovascular events HR: 1.12 [1.02, 1.23] — — PGS002258 *NOTE*: PGS is calculated as an average of PGS002257 and PGS002258
PPM013004 PGS002258
(GRS901_DBP)
 PSS009643|
Ancestry Not Reported|
6,335 individuals
 PGP000317 |
Parcha V et al. Hypertension (2022)
|Ext.		 Reported Trait: Systolic blood pressure β: 1.93 — — PGS002257, age, age^2, sex, BMI, randomization arm, history of CVD event, serum creatinine, fasting blood glucose, LDL levels, 10 genetic PCs *NOTE*: PGS is calculated as an average of PGS002257 and PGS002258
PPM013005 PGS002258
(GRS901_DBP)
 PSS009643|
Ancestry Not Reported|
6,335 individuals
 PGP000317 |
Parcha V et al. Hypertension (2022)
|Ext.		 Reported Trait: Diastolic blood pressure β: 0.65 — — PGS002257, age, age^2, sex, BMI, randomization arm, history of CVD event, serum creatinine, fasting blood glucose, LDL levels, 10 genetic PCs *NOTE*: PGS is calculated as an average of PGS002257 and PGS002258
PPM013006 PGS002258
(GRS901_DBP)
 PSS009643|
Ancestry Not Reported|
6,335 individuals
 PGP000317 |
Parcha V et al. Hypertension (2022)
|Ext.		 Reported Trait: Adverse cardiovascular events HR: 1.12 [1.02, 1.23] — — PGS002257 *NOTE*: PGS is calculated as an average of PGS002257 and PGS002258
PPM013001 PGS002257
(GRS901_SBP)
 PSS009643|
Ancestry Not Reported|
6,335 individuals
 PGP000317 |
Parcha V et al. Hypertension (2022)
|Ext.		 Reported Trait: Systolic blood pressure β: 1.93 — — PGS002258, age, age^2, sex, BMI, randomization arm, history of CVD event, serum creatinine, fasting blood glucose, LDL levels, 10 genetic PCs *NOTE*: PGS is calculated as an average of PGS002257 and PGS002258

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009643 Corrected for baseline antihypertensive use — 6,335 individuals,
62.7 % Male samples
 Median = 62.1 years
Sd = [57.8, 67.1] years		 Not reported 30.4% non-White individuals ACCORD —