PGS Publication: PGP000376

Publication Information (EuropePMC)
Title Association between arterial hypertension and liver outcomes using polygenic risk scores: a population-based study.
PubMed ID 36114231(Europe PMC)
doi 10.1038/s41598-022-20084-z
Publication Date Sept. 16, 2022
Journal Sci Rep
Author(s) Åberg F, Kantojärvi K, Männistö V, But A, Salomaa V, Niiranen T, Färkkilä M, Luukkonen P, Männistö S, Lundqvist A, Perola M, Jula A.
Released in PGS Catalog: Oct. 19, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002257
(GRS901_SBP)
 PGP000283 |
Evangelou E et al. Nat Genet (2018)
 Systolic blood pressure systolic blood pressure 884
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002257/ScoringFiles/PGS002257.txt.gz
PGS002258
(GRS901_DBP)
 PGP000283 |
Evangelou E et al. Nat Genet (2018)
 Diastolic blood pressure diastolic blood pressure 885
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002258/ScoringFiles/PGS002258.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015498 PGS002257
(GRS901_SBP)
 PSS009963|
European Ancestry|
33,770 individuals
 PGP000376 |
Åberg F et al. Sci Rep (2022)
|Ext.		 Reported Trait: Liver-related outcome HR: 1.19 [1.01, 1.24] — — Age, sex, body mass index, waist circumference, weekly alcohol use, fraction of alcohol use as wine, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, diabetes, exercise habits, smoking status (current, former, never smoker) and baseline cardiovascular disease —
PPM015499 PGS002258
(GRS901_DBP)
 PSS009963|
European Ancestry|
33,770 individuals
 PGP000376 |
Åberg F et al. Sci Rep (2022)
|Ext.		 Reported Trait: Liver-related outcome HR: 1.12 [1.01, 1.25] — — Age, sex, body mass index, waist circumference, weekly alcohol use, fraction of alcohol use as wine, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, diabetes, exercise habits, smoking status (current, former, never smoker) and baseline cardiovascular disease —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009963 — Median = 12.9 years 33,770 individuals,
46.5 % Male samples
 Mean = 49.6 years European
(Finnish)		 Finland FINRISK, Health2000 —