| Publication Information (EuropePMC) | |
| Title | Associations of polygenic inheritance of physical activity with aerobic fitness, cardiometabolic risk factors and diseases: the HUNT study. |
| PubMed ID | 37603226(Europe PMC) |
| doi | 10.1007/s10654-023-01029-w |
| Publication Date | Aug. 21, 2023 |
| Journal | Eur J Epidemiol |
| Author(s) | Tynkkynen NP, Törmäkangas T, Palviainen T, Hyvärinen M, Klevjer M, Joensuu L, Kujala U, Kaprio J, Bye A, Sillanpää E. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS002254 (PRS_reported) |
PGP000280 | Kujala UM et al. Med Sci Sports Exerc (2020) |
Physical activity (self-reported) | physical activity measurement, self-reported trait |
1,142,416 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002254/ScoringFiles/PGS002254.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM021392 | PGS002254 (PRS_reported) |
PSS011726| European Ancestry| 47,148 individuals |
PGP000653 | Tynkkynen NP et al. Eur J Epidemiol (2023) |Ext. |
Reported Trait: Self-reported leisure time physical activity | β: 0.282 [0.211, 0.354] | — | R²: 0.014 | Age, sex, 10 PCs | — |
| PPM021393 | PGS002254 (PRS_reported) |
PSS011726| European Ancestry| 47,148 individuals |
PGP000653 | Tynkkynen NP et al. Eur J Epidemiol (2023) |Ext. |
Reported Trait: Waist circumference | β: -0.003 [-0.004, -0.002] | — | R²: 0.137 | Age, sex, 10 PCs | — |
| PPM021394 | PGS002254 (PRS_reported) |
PSS011726| European Ancestry| 47,148 individuals |
PGP000653 | Tynkkynen NP et al. Eur J Epidemiol (2023) |Ext. |
Reported Trait: Body mass index | β: -0.002 [-0.004, -0.001] | — | R²: 0.026 | Age, sex, 10 PCs | — |
| PPM021395 | PGS002254 (PRS_reported) |
PSS011726| European Ancestry| 47,148 individuals |
PGP000653 | Tynkkynen NP et al. Eur J Epidemiol (2023) |Ext. |
Reported Trait: HDL cholesterol | β: 0.004 [0.002, 0.006] | — | R²: 0.134 | Age, sex, 10 PCs | — |
| PPM021396 | PGS002254 (PRS_reported) |
PSS011725| European Ancestry| 24,960 individuals |
PGP000653 | Tynkkynen NP et al. Eur J Epidemiol (2023) |Ext. |
Reported Trait: Stroke | HR: 0.94 [0.903, 0.978] | — | — | — | — |
| PPM021397 | PGS002254 (PRS_reported) |
PSS011725| European Ancestry| 24,960 individuals |
PGP000653 | Tynkkynen NP et al. Eur J Epidemiol (2023) |Ext. |
Reported Trait: Hypertensive diseases | HR: 0.97 [0.951, 0.99] | — | — | — | — |
| PPM021398 | PGS002254 (PRS_reported) |
PSS011725| European Ancestry| 24,960 individuals |
PGP000653 | Tynkkynen NP et al. Eur J Epidemiol (2023) |Ext. |
Reported Trait: Type 2 diabetes | HR: 0.935 [0.902, 0.97] | — | — | — | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS011725 | — | — | 24,960 individuals, 46.5 % Male samples |
Mean = 59.1 years Sd = 14.6 years |
European | — | HUNT | — |
| PSS011726 | — | — | 47,148 individuals, 45.9 % Male samples |
Mean = 52.9 years Sd = 15.8 years |
European | — | HUNT | — |