| Publication Information (EuropePMC) | |
| Title | Integrated clinical risk prediction of type 2 diabetes with a multifactorial polygenic risk score |
| doi | 10.1101/2024.08.22.24312440 |
| Publication Date | Aug. 22, 2024 |
| Journal | medRxiv Preprint |
| Author(s) | Ritchie SC, Taylor HJ, Liang Y, Manikpurage HD, Pennells L, Foguet C, Abraham G, Gibson JT, Jiang X, Liu Y, Kim LG, Mahajan A, Mccarthy MI, Kaptoge S, Lambert SA, Wood A, Sim X, Collins FS, Denny JC, Danesh J, Butterworth AS, Di Angelantonio E, Inouye M. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS004923 (T2D_metaGRS) |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,349,896 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004923/ScoringFiles/PGS004923.txt.gz |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000014 (GPS_T2D) |
PGP000006 | Khera AV et al. Nat Genet (2018) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 6,917,436 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000014/ScoringFiles/PGS000014.txt.gz | |
| PGS001818 (portability-PLR_250.2) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 30,745 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001818/ScoringFiles/PGS001818.txt.gz |
| PGS003867 (T2D_PRScs_ARB) |
PGP000501 | Shim I et al. Nature Communications (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,068,166 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003867/ScoringFiles/PGS003867.txt.gz |
| PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PGP000393 | Ma Y et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 945,820 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003103/ScoringFiles/PGS003103.txt.gz | |
| PGS000036 (gePS_T2D) |
PGP000023 | Mahajan A et al. Nat Genet (2018) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 171,249 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000036/ScoringFiles/PGS000036.txt.gz | |
| PGS000805 (GRS582_T2Deur) |
PGP000193 | Polfus LM et al. HGG Adv (2021) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 582 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000805/ScoringFiles/PGS000805.txt.gz |
| PGS002243 (ldpred_t2d) |
PGP000271 | Mars N et al. Cell Genom (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 6,431,973 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002243/ScoringFiles/PGS002243.txt.gz | |
| PGS000713 (T2D) |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 183,830 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000713/ScoringFiles/PGS000713.txt.gz |
| PGS000330 (PRS_T2D) |
PGP000100 | Mars N et al. Nat Med (2020) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 6,437,380 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000330/ScoringFiles/PGS000330.txt.gz | |
| PGS001357 (T2D_AnnoPred_PRS) |
PGP000252 | Ye Y et al. Circ Genom Precis Med (2021) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 2,996,761 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001357/ScoringFiles/PGS001357.txt.gz | |
| PGS002771 (Type_2_diabetes_prscs) |
PGP000364 | Mars N et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,091,608 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002771/ScoringFiles/PGS002771.txt.gz |
| PGS000729 (T2D_PGS) |
PGP000137 | Ritchie SC et al. Nat Metab (2021) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 2,017,388 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000729/ScoringFiles/PGS000729.txt.gz |
| PGS002780 (GTG_T2D_SCT) |
PGP000365 | Wong CK et al. PLoS One (2022) |
Incident type 2 diabetes | type 2 diabetes mellitus | 419,209 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002780/ScoringFiles/PGS002780.txt.gz | |
| PGS000864 (T2D-gPRS) |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 389,243 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000864/ScoringFiles/PGS000864.txt.gz |
| PGS000868 (T2D_221) |
PGP000214 | Aksit MA et al. J Clin Endocrinol Metab (2020) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 221 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000868/ScoringFiles/PGS000868.txt.gz |
| PGS002026 (portability-ldpred2_250.2) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 830,783 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002026/ScoringFiles/PGS002026.txt.gz |
| PGS002671 (disease_T2D.PolyFun-pred) |
PGP000332 | Weissbrod O et al. Nat Genet (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 258,382 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002671/ScoringFiles/PGS002671.txt.gz |
| PGS003443 (PRScsx_T2D_LAT_EURweights) |
PGP000445 | Huerta-Chagoya A et al. Diabetologia (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,092,496 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003443/ScoringFiles/PGS003443.txt.gz | |
| PGS003444 (PRScsx_T2D_LAT_EASweights) |
PGP000445 | Huerta-Chagoya A et al. Diabetologia (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,001,579 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003444/ScoringFiles/PGS003444.txt.gz | |
| PGS003445 (PRScsx_T2D_LAT_LATweights) |
PGP000445 | Huerta-Chagoya A et al. Diabetologia (2023) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,149,210 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003445/ScoringFiles/PGS003445.txt.gz | |
| PGS001781 (T2D_PRSCS) |
PGP000261 | Tamlander M et al. Commun Biol (2022) |
Type 2 diabetes (T2D) | type 2 diabetes mellitus | 1,091,673 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001781/ScoringFiles/PGS001781.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM021411 | PGS002771 (Type_2_diabetes_prscs) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.89 [1.85, 1.94] | AUROC: 0.735 [0.73, 0.74] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021413 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.86 [1.82, 1.9] | AUROC: 0.731 [0.726, 0.736] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021414 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.86 [1.82, 1.9] | AUROC: 0.731 [0.726, 0.736] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021415 | PGS003867 (T2D_PRScs_ARB) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.84 [1.8, 1.88] | AUROC: 0.73 [0.725, 0.735] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021416 | PGS000330 (PRS_T2D) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.79 [1.75, 1.83] | AUROC: 0.726 [0.721, 0.73] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021417 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.77 [1.74, 1.81] | AUROC: 0.725 [0.72, 0.729] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021418 | PGS002026 (portability-ldpred2_250.2) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.67 [1.63, 1.71] | AUROC: 0.714 [0.709, 0.719] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021419 | PGS000729 (T2D_PGS) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.65 [1.61, 1.68] | AUROC: 0.712 [0.707, 0.717] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021420 | PGS000713 (T2D) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.63 [1.6, 1.67] | AUROC: 0.712 [0.707, 0.717] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021421 | PGS001818 (portability-PLR_250.2) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.62 [1.58, 1.65] | AUROC: 0.709 [0.704, 0.714] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021422 | PGS000805 (GRS582_T2Deur) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.59 [1.56, 1.63] | AUROC: 0.707 [0.702, 0.712] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021423 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.56 [1.53, 1.59] | AUROC: 0.704 [0.699, 0.709] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021424 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.55 [1.52, 1.59] | AUROC: 0.704 [0.699, 0.708] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021425 | PGS002243 (ldpred_t2d) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.55 [1.52, 1.59] | AUROC: 0.703 [0.698, 0.708] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021426 | PGS001781 (T2D_PRSCS) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.54 [1.51, 1.58] | AUROC: 0.702 [0.698, 0.707] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021427 | PGS000036 (gePS_T2D) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.53 [1.5, 1.56] | AUROC: 0.701 [0.696, 0.706] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021428 | PGS000014 (GPS_T2D) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.51 [1.48, 1.55] | AUROC: 0.7 [0.695, 0.705] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021429 | PGS000868 (T2D_221) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.48 [1.45, 1.51] | AUROC: 0.696 [0.691, 0.701] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021432 | PGS004923 (T2D_metaGRS) |
PSS011747| European Ancestry| 245,177 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Type 2 diabetes | OR: 2.3 [2.26, 2.35] | AUROC: 0.777 [0.772, 0.781] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021433 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011747| European Ancestry| 245,177 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.8 [1.77, 1.84] | AUROC: 0.739 [0.734, 0.743] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021434 | PGS002243 (ldpred_t2d) |
PSS011747| European Ancestry| 245,177 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.78 [1.75, 1.82] | AUROC: 0.737 [0.733, 0.742] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021435 | PGS001781 (T2D_PRSCS) |
PSS011747| European Ancestry| 245,177 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.77 [1.74, 1.81] | AUROC: 0.736 [0.732, 0.741] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021436 | PGS000036 (gePS_T2D) |
PSS011747| European Ancestry| 245,177 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.73 [1.69, 1.76] | AUROC: 0.733 [0.728, 0.737] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021437 | PGS000014 (GPS_T2D) |
PSS011747| European Ancestry| 245,177 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.71 [1.67, 1.74] | AUROC: 0.731 [0.726, 0.736] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021438 | PGS004923 (T2D_metaGRS) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Incident type 2 diabetes | HR: 2.07 [1.92, 2.23] | C-index: 0.774 [0.758, 0.79] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021439 | PGS002771 (Type_2_diabetes_prscs) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 2.03 [1.88, 2.18] | C-index: 0.772 [0.756, 0.788] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021441 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.98 [1.84, 2.13] | C-index: 0.77 [0.754, 0.786] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021442 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.98 [1.84, 2.13] | C-index: 0.77 [0.754, 0.786] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021443 | PGS003867 (T2D_PRScs_ARB) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.95 [1.81, 2.1] | C-index: 0.766 [0.75, 0.782] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021444 | PGS000330 (PRS_T2D) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.94 [1.8, 2.09] | C-index: 0.767 [0.75, 0.783] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021445 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.89 [1.76, 2.04] | C-index: 0.759 [0.743, 0.775] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021446 | PGS002026 (portability-ldpred2_250.2) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.81 [1.68, 1.95] | C-index: 0.752 [0.735, 0.769] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021447 | PGS001818 (portability-PLR_250.2) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.75 [1.63, 1.89] | C-index: 0.75 [0.734, 0.767] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021448 | PGS000729 (T2D_PGS) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.75 [1.62, 1.88] | C-index: 0.753 [0.737, 0.77] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021449 | PGS000713 (T2D) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.74 [1.62, 1.88] | C-index: 0.748 [0.732, 0.765] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021450 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.67 [1.56, 1.8] | C-index: 0.742 [0.724, 0.759] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021451 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.65 [1.53, 1.77] | C-index: 0.742 [0.725, 0.76] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021452 | PGS002780 (GTG_T2D_SCT) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.65 [1.53, 1.77] | C-index: 0.742 [0.725, 0.759] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021453 | PGS002243 (ldpred_t2d) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.64 [1.53, 1.77] | C-index: 0.741 [0.723, 0.758] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021454 | PGS000036 (gePS_T2D) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.63 [1.52, 1.75] | C-index: 0.742 [0.725, 0.759] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021455 | PGS001781 (T2D_PRSCS) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.61 [1.5, 1.73] | C-index: 0.741 [0.723, 0.758] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021456 | PGS000868 (T2D_221) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.6 [1.48, 1.72] | C-index: 0.736 [0.719, 0.753] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021457 | PGS000805 (GRS582_T2Deur) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.59 [1.48, 1.71] | C-index: 0.736 [0.718, 0.753] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021458 | PGS000014 (GPS_T2D) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.58 [1.47, 1.7] | C-index: 0.737 [0.719, 0.754] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021459 | PGS000864 (T2D-gPRS) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.32 [1.27, 1.38] | C-index: 0.731 [0.714, 0.749] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021460 | PGS004923 (T2D_metaGRS) |
PSS011746| European Ancestry| 232,808 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.8 [1.75, 1.85] | C-index: 0.719 [0.713, 0.725] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021461 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011746| European Ancestry| 232,808 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.51 [1.47, 1.55] | C-index: 0.69 [0.684, 0.696] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021462 | PGS002243 (ldpred_t2d) |
PSS011746| European Ancestry| 232,808 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.49 [1.45, 1.52] | C-index: 0.689 [0.683, 0.695] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021463 | PGS001781 (T2D_PRSCS) |
PSS011746| European Ancestry| 232,808 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.48 [1.45, 1.52] | C-index: 0.688 [0.682, 0.695] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021464 | PGS000036 (gePS_T2D) |
PSS011746| European Ancestry| 232,808 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.46 [1.42, 1.5] | C-index: 0.687 [0.68, 0.693] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021465 | PGS000014 (GPS_T2D) |
PSS011746| European Ancestry| 232,808 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.45 [1.42, 1.49] | C-index: 0.686 [0.679, 0.692] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021466 | PGS003867 (T2D_PRScs_ARB) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.37 [1.33, 1.41] | AUROC: 0.727 [0.72, 0.733] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021467 | PGS004923 (T2D_metaGRS) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Type 2 diabetes | OR: 1.35 [1.31, 1.39] | AUROC: 0.725 [0.718, 0.731] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021468 | PGS002771 (Type_2_diabetes_prscs) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.33 [1.3, 1.37] | AUROC: 0.724 [0.717, 0.73] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021469 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.32 [1.28, 1.36] | AUROC: 0.723 [0.717, 0.729] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021470 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.32 [1.28, 1.36] | AUROC: 0.723 [0.717, 0.729] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021471 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.32 [1.28, 1.36] | AUROC: 0.723 [0.717, 0.729] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021473 | PGS002026 (portability-ldpred2_250.2) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.28 [1.24, 1.32] | AUROC: 0.721 [0.714, 0.727] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021474 | PGS000330 (PRS_T2D) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.27 [1.23, 1.31] | AUROC: 0.72 [0.714, 0.727] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021475 | PGS001818 (portability-PLR_250.2) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.27 [1.23, 1.3] | AUROC: 0.72 [0.714, 0.727] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021476 | PGS002243 (ldpred_t2d) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.23 [1.2, 1.27] | AUROC: 0.718 [0.712, 0.725] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021477 | PGS000805 (GRS582_T2Deur) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.23 [1.2, 1.27] | AUROC: 0.718 [0.711, 0.724] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021478 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.23 [1.2, 1.27] | AUROC: 0.718 [0.711, 0.724] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021479 | PGS000713 (T2D) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.23 [1.2, 1.27] | AUROC: 0.718 [0.711, 0.724] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021480 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.22 [1.19, 1.26] | AUROC: 0.718 [0.711, 0.724] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021481 | PGS000729 (T2D_PGS) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.23 [1.19, 1.26] | AUROC: 0.718 [0.711, 0.724] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021482 | PGS000036 (gePS_T2D) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.21 [1.18, 1.25] | AUROC: 0.717 [0.711, 0.724] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021483 | PGS000868 (T2D_221) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.21 [1.17, 1.24] | AUROC: 0.717 [0.711, 0.724] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021484 | PGS000014 (GPS_T2D) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.21 [1.17, 1.24] | AUROC: 0.717 [0.71, 0.723] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021485 | PGS001781 (T2D_PRSCS) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.2 [1.16, 1.23] | AUROC: 0.716 [0.71, 0.723] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021486 | PGS002780 (GTG_T2D_SCT) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.18 [1.14, 1.21] | AUROC: 0.715 [0.709, 0.722] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021489 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.77 [1.71, 1.84] | AUROC: 0.78 [0.773, 0.786] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021490 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.77 [1.71, 1.84] | AUROC: 0.78 [0.773, 0.786] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021491 | PGS004923 (T2D_metaGRS) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Type 2 diabetes | OR: 1.73 [1.67, 1.79] | AUROC: 0.777 [0.77, 0.783] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021492 | PGS003867 (T2D_PRScs_ARB) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.72 [1.65, 1.78] | AUROC: 0.776 [0.769, 0.783] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021493 | PGS002771 (Type_2_diabetes_prscs) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.7 [1.64, 1.76] | AUROC: 0.775 [0.769, 0.782] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021494 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.61 [1.55, 1.67] | AUROC: 0.77 [0.764, 0.777] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021495 | PGS000330 (PRS_T2D) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.58 [1.53, 1.64] | AUROC: 0.768 [0.761, 0.775] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021496 | PGS002026 (portability-ldpred2_250.2) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.49 [1.44, 1.55] | AUROC: 0.764 [0.757, 0.771] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021497 | PGS000805 (GRS582_T2Deur) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.49 [1.44, 1.55] | AUROC: 0.764 [0.758, 0.771] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021498 | PGS001818 (portability-PLR_250.2) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.46 [1.41, 1.51] | AUROC: 0.762 [0.755, 0.769] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021499 | PGS000713 (T2D) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.46 [1.41, 1.51] | AUROC: 0.762 [0.755, 0.769] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021500 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.45 [1.4, 1.51] | AUROC: 0.761 [0.754, 0.768] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021501 | PGS000729 (T2D_PGS) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.45 [1.4, 1.51] | AUROC: 0.761 [0.754, 0.768] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021502 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.44 [1.39, 1.49] | AUROC: 0.761 [0.754, 0.768] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021503 | PGS002243 (ldpred_t2d) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.43 [1.38, 1.48] | AUROC: 0.76 [0.753, 0.767] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021504 | PGS001781 (T2D_PRSCS) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.43 [1.38, 1.48] | AUROC: 0.76 [0.753, 0.767] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021505 | PGS000036 (gePS_T2D) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.41 [1.36, 1.46] | AUROC: 0.759 [0.752, 0.766] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021506 | PGS000014 (GPS_T2D) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.39 [1.34, 1.44] | AUROC: 0.757 [0.75, 0.764] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021507 | PGS000868 (T2D_221) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.38 [1.33, 1.43] | AUROC: 0.758 [0.751, 0.765] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021508 | PGS002780 (GTG_T2D_SCT) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.35 [1.31, 1.4] | AUROC: 0.756 [0.749, 0.763] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021509 | PGS000864 (T2D-gPRS) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.02 [0.99, 1.06] | AUROC: 0.745 [0.738, 0.752] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021510 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.51 [1.29, 1.77] | AUROC: 0.648 [0.607, 0.688] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021511 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.51 [1.29, 1.77] | AUROC: 0.648 [0.607, 0.688] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021512 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.51 [1.29, 1.77] | AUROC: 0.648 [0.607, 0.688] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021513 | PGS003867 (T2D_PRScs_ARB) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.42 [1.22, 1.66] | AUROC: 0.635 [0.594, 0.676] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021514 | PGS002771 (Type_2_diabetes_prscs) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.4 [1.2, 1.64] | AUROC: 0.634 [0.592, 0.676] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021515 | PGS004923 (T2D_metaGRS) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.37 [1.17, 1.6] | AUROC: 0.627 [0.585, 0.669] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021517 | PGS001818 (portability-PLR_250.2) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.3 [1.11, 1.51] | AUROC: 0.622 [0.581, 0.664] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021518 | PGS000805 (GRS582_T2Deur) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.3 [1.11, 1.52] | AUROC: 0.613 [0.572, 0.654] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021519 | PGS000330 (PRS_T2D) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.29 [1.11, 1.51] | AUROC: 0.619 [0.577, 0.661] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021520 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.28 [1.1, 1.5] | AUROC: 0.619 [0.578, 0.661] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021521 | PGS000036 (gePS_T2D) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.25 [1.07, 1.46] | AUROC: 0.608 [0.566, 0.651] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021522 | PGS000729 (T2D_PGS) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.25 [1.07, 1.46] | AUROC: 0.615 [0.572, 0.657] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021523 | PGS000868 (T2D_221) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.24 [1.06, 1.44] | AUROC: 0.604 [0.564, 0.645] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021524 | PGS000713 (T2D) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.19 [1.02, 1.39] | AUROC: 0.598 [0.554, 0.641] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021525 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.15 [0.98, 1.34] | AUROC: 0.593 [0.55, 0.636] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021526 | PGS002780 (GTG_T2D_SCT) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.14 [0.98, 1.33] | AUROC: 0.598 [0.556, 0.641] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021527 | PGS001781 (T2D_PRSCS) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.12 [0.96, 1.3] | AUROC: 0.593 [0.551, 0.636] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021528 | PGS002243 (ldpred_t2d) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.08 [0.93, 1.26] | AUROC: 0.592 [0.548, 0.635] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021529 | PGS000864 (T2D-gPRS) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.04 [0.9, 1.21] | AUROC: 0.584 [0.54, 0.628] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021530 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 0.98 [0.84, 1.14] | AUROC: 0.585 [0.541, 0.629] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021531 | PGS000014 (GPS_T2D) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 0.99 [0.85, 1.16] | AUROC: 0.585 [0.541, 0.629] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021532 | PGS004923 (T2D_metaGRS) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.69 [1.42, 2.02] | AUROC: 0.698 [0.658, 0.737] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021533 | PGS002771 (Type_2_diabetes_prscs) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.57 [1.32, 1.87] | AUROC: 0.682 [0.642, 0.723] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021534 | PGS001818 (portability-PLR_250.2) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.54 [1.3, 1.83] | AUROC: 0.677 [0.634, 0.72] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021535 | PGS003867 (T2D_PRScs_ARB) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.52 [1.29, 1.81] | AUROC: 0.681 [0.641, 0.722] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021536 | PGS000868 (T2D_221) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.52 [1.28, 1.8] | AUROC: 0.677 [0.635, 0.72] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021538 | PGS002026 (portability-ldpred2_250.2) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.43 [1.21, 1.7] | AUROC: 0.666 [0.623, 0.708] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021539 | PGS002780 (GTG_T2D_SCT) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.43 [1.21, 1.69] | AUROC: 0.666 [0.624, 0.708] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021541 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.43 [1.21, 1.7] | AUROC: 0.667 [0.626, 0.708] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021542 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.43 [1.21, 1.7] | AUROC: 0.667 [0.626, 0.708] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021543 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.38 [1.17, 1.64] | AUROC: 0.667 [0.626, 0.709] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021544 | PGS000330 (PRS_T2D) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.32 [1.12, 1.57] | AUROC: 0.66 [0.619, 0.701] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021545 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.27 [1.08, 1.5] | AUROC: 0.655 [0.613, 0.696] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021546 | PGS000729 (T2D_PGS) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.25 [1.06, 1.48] | AUROC: 0.653 [0.612, 0.694] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021547 | PGS000036 (gePS_T2D) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.23 [1.04, 1.45] | AUROC: 0.651 [0.609, 0.693] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021548 | PGS002243 (ldpred_t2d) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.12 [0.95, 1.32] | AUROC: 0.643 [0.6, 0.685] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021549 | PGS001781 (T2D_PRSCS) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.12 [0.95, 1.32] | AUROC: 0.645 [0.602, 0.687] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021550 | PGS000713 (T2D) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 0.91 [0.77, 1.08] | AUROC: 0.643 [0.6, 0.686] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021551 | PGS000864 (T2D-gPRS) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.09 [0.93, 1.28] | AUROC: 0.643 [0.6, 0.686] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021552 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 0.96 [0.81, 1.13] | AUROC: 0.641 [0.598, 0.684] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021553 | PGS000014 (GPS_T2D) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.03 [0.87, 1.21] | AUROC: 0.639 [0.596, 0.683] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021554 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.71 [1.43, 2.06] | AUROC: 0.706 [0.665, 0.746] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021555 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.71 [1.43, 2.06] | AUROC: 0.706 [0.665, 0.746] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021556 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.71 [1.43, 2.06] | AUROC: 0.706 [0.665, 0.746] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021557 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.68 [1.4, 2.01] | AUROC: 0.705 [0.664, 0.745] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021559 | PGS003867 (T2D_PRScs_ARB) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.64 [1.37, 1.98] | AUROC: 0.701 [0.659, 0.742] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021560 | PGS002771 (Type_2_diabetes_prscs) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.62 [1.36, 1.95] | AUROC: 0.696 [0.654, 0.738] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021561 | PGS000805 (GRS582_T2Deur) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.58 [1.33, 1.88] | AUROC: 0.701 [0.659, 0.743] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021562 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.5 [1.26, 1.79] | AUROC: 0.682 [0.64, 0.725] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021564 | PGS002026 (portability-ldpred2_250.2) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.44 [1.22, 1.72] | AUROC: 0.685 [0.643, 0.727] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021565 | PGS000729 (T2D_PGS) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.37 [1.16, 1.63] | AUROC: 0.668 [0.625, 0.712] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021566 | PGS001781 (T2D_PRSCS) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.37 [1.16, 1.63] | AUROC: 0.672 [0.629, 0.715] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021567 | PGS001818 (portability-PLR_250.2) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.36 [1.15, 1.62] | AUROC: 0.675 [0.632, 0.718] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021568 | PGS000868 (T2D_221) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.34 [1.14, 1.6] | AUROC: 0.674 [0.631, 0.717] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021569 | PGS002243 (ldpred_t2d) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.32 [1.11, 1.57] | AUROC: 0.669 [0.625, 0.712] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021570 | PGS002780 (GTG_T2D_SCT) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.27 [1.07, 1.5] | AUROC: 0.668 [0.625, 0.711] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021571 | PGS000014 (GPS_T2D) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 0.82 [0.69, 0.97] | AUROC: 0.662 [0.618, 0.706] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021572 | PGS000036 (gePS_T2D) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.2 [1.01, 1.42] | AUROC: 0.657 [0.612, 0.701] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021573 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.05 [0.89, 1.24] | AUROC: 0.655 [0.611, 0.698] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021574 | PGS000713 (T2D) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 0.95 [0.8, 1.12] | AUROC: 0.652 [0.608, 0.696] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021575 | PGS000864 (T2D-gPRS) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 0.98 [0.83, 1.16] | AUROC: 0.653 [0.609, 0.697] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021576 | PGS004923 (T2D_metaGRS) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Type 2 diabetes | OR: 1.41 [1.31, 1.53] | AUROC: 0.723 [0.704, 0.742] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021577 | PGS002771 (Type_2_diabetes_prscs) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.41 [1.3, 1.53] | AUROC: 0.724 [0.705, 0.743] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021579 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.4 [1.3, 1.52] | AUROC: 0.723 [0.705, 0.742] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021580 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.4 [1.3, 1.52] | AUROC: 0.723 [0.705, 0.742] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021581 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.4 [1.29, 1.51] | AUROC: 0.721 [0.702, 0.74] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021582 | PGS002026 (portability-ldpred2_250.2) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.35 [1.24, 1.46] | AUROC: 0.719 [0.7, 0.737] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021583 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.32 [1.22, 1.43] | AUROC: 0.717 [0.698, 0.736] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021584 | PGS001818 (portability-PLR_250.2) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.32 [1.22, 1.43] | AUROC: 0.716 [0.697, 0.735] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021585 | PGS002243 (ldpred_t2d) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.31 [1.21, 1.42] | AUROC: 0.716 [0.696, 0.735] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021586 | PGS000330 (PRS_T2D) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.31 [1.21, 1.42] | AUROC: 0.716 [0.696, 0.735] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021587 | PGS000713 (T2D) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.31 [1.21, 1.42] | AUROC: 0.714 [0.695, 0.734] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021588 | PGS001781 (T2D_PRSCS) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.29 [1.2, 1.4] | AUROC: 0.714 [0.695, 0.733] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021589 | PGS000014 (GPS_T2D) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.27 [1.18, 1.38] | AUROC: 0.714 [0.695, 0.733] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021590 | PGS000805 (GRS582_T2Deur) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.27 [1.18, 1.38] | AUROC: 0.714 [0.694, 0.733] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021591 | PGS000036 (gePS_T2D) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.25 [1.16, 1.35] | AUROC: 0.71 [0.691, 0.729] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021592 | PGS000729 (T2D_PGS) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.25 [1.15, 1.35] | AUROC: 0.711 [0.692, 0.73] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021593 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.23 [1.14, 1.33] | AUROC: 0.711 [0.692, 0.73] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021594 | PGS000868 (T2D_221) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.19 [1.1, 1.29] | AUROC: 0.708 [0.689, 0.728] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021595 | PGS002780 (GTG_T2D_SCT) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.17 [1.09, 1.27] | AUROC: 0.708 [0.689, 0.727] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021596 | PGS000864 (T2D-gPRS) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.08 [1.0, 1.17] | AUROC: 0.705 [0.686, 0.724] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021597 | PGS000713 (T2D) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.9 [1.48, 2.45] | AUROC: 0.754 [0.7, 0.808] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021598 | PGS004923 (T2D_metaGRS) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Type 2 diabetes | OR: 1.82 [1.42, 2.37] | AUROC: 0.734 [0.678, 0.79] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021599 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.8 [1.4, 2.32] | AUROC: 0.738 [0.684, 0.791] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021641 | PGS002771 (Type_2_diabetes_prscs) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.18 [1.07, 1.31] | C-index: 0.645 [0.618, 0.672] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021601 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.8 [1.4, 2.32] | AUROC: 0.738 [0.684, 0.791] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021602 | PGS001818 (portability-PLR_250.2) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.74 [1.36, 2.22] | AUROC: 0.734 [0.679, 0.788] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021603 | PGS000805 (GRS582_T2Deur) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.7 [1.35, 2.16] | AUROC: 0.734 [0.679, 0.788] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021604 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.73 [1.35, 2.21] | AUROC: 0.737 [0.68, 0.793] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021605 | PGS002026 (portability-ldpred2_250.2) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.6 [1.26, 2.03] | AUROC: 0.722 [0.664, 0.78] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021606 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.61 [1.26, 2.07] | AUROC: 0.726 [0.67, 0.781] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021607 | PGS002771 (Type_2_diabetes_prscs) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.64 [1.27, 2.12] | AUROC: 0.728 [0.673, 0.783] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021608 | PGS000868 (T2D_221) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.57 [1.24, 2.0] | AUROC: 0.727 [0.672, 0.782] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021609 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.45 [1.14, 1.84] | AUROC: 0.712 [0.655, 0.769] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021610 | PGS002780 (GTG_T2D_SCT) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.44 [1.13, 1.83] | AUROC: 0.712 [0.655, 0.769] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021611 | PGS000330 (PRS_T2D) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.43 [1.12, 1.83] | AUROC: 0.714 [0.658, 0.77] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021612 | PGS000036 (gePS_T2D) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.39 [1.1, 1.77] | AUROC: 0.722 [0.668, 0.776] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021613 | PGS000729 (T2D_PGS) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.4 [1.1, 1.8] | AUROC: 0.718 [0.666, 0.771] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021614 | PGS002243 (ldpred_t2d) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.36 [1.08, 1.73] | AUROC: 0.708 [0.65, 0.766] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021615 | PGS000014 (GPS_T2D) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.28 [1.01, 1.61] | AUROC: 0.705 [0.648, 0.763] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021616 | PGS001781 (T2D_PRSCS) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.22 [0.96, 1.55] | AUROC: 0.704 [0.647, 0.761] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021617 | PGS000864 (T2D-gPRS) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.05 [0.83, 1.32] | AUROC: 0.7 [0.643, 0.757] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021619 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.91 [1.78, 2.05] | AUROC: 0.746 [0.732, 0.761] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021620 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.91 [1.78, 2.05] | AUROC: 0.746 [0.732, 0.761] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021621 | PGS004923 (T2D_metaGRS) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Type 2 diabetes | OR: 1.88 [1.75, 2.01] | AUROC: 0.742 [0.727, 0.756] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021622 | PGS002771 (Type_2_diabetes_prscs) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.85 [1.73, 1.99] | AUROC: 0.742 [0.728, 0.757] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021623 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.72 [1.6, 1.84] | AUROC: 0.73 [0.715, 0.745] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021624 | PGS002026 (portability-ldpred2_250.2) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.64 [1.53, 1.75] | AUROC: 0.724 [0.709, 0.739] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021625 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.62 [1.52, 1.73] | AUROC: 0.723 [0.708, 0.738] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021626 | PGS000330 (PRS_T2D) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.62 [1.51, 1.73] | AUROC: 0.724 [0.709, 0.738] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021627 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.61 [1.51, 1.72] | AUROC: 0.721 [0.706, 0.736] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021628 | PGS001818 (portability-PLR_250.2) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.61 [1.51, 1.72] | AUROC: 0.723 [0.708, 0.738] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021629 | PGS000805 (GRS582_T2Deur) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.61 [1.51, 1.73] | AUROC: 0.721 [0.706, 0.736] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021630 | PGS000713 (T2D) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.59 [1.49, 1.7] | AUROC: 0.721 [0.705, 0.736] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021631 | PGS002243 (ldpred_t2d) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.57 [1.47, 1.67] | AUROC: 0.718 [0.703, 0.733] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021632 | PGS000729 (T2D_PGS) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.55 [1.45, 1.66] | AUROC: 0.717 [0.703, 0.732] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021633 | PGS001781 (T2D_PRSCS) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.53 [1.43, 1.64] | AUROC: 0.716 [0.701, 0.731] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021634 | PGS002780 (GTG_T2D_SCT) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.53 [1.43, 1.63] | AUROC: 0.713 [0.698, 0.729] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021635 | PGS000014 (GPS_T2D) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.48 [1.39, 1.58] | AUROC: 0.711 [0.696, 0.726] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021636 | PGS000868 (T2D_221) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.49 [1.39, 1.59] | AUROC: 0.711 [0.696, 0.726] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021637 | PGS000036 (gePS_T2D) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.44 [1.35, 1.54] | AUROC: 0.707 [0.692, 0.722] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021638 | PGS000864 (T2D-gPRS) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.23 [1.16, 1.31] | AUROC: 0.693 [0.678, 0.709] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021639 | PGS004923 (T2D_metaGRS) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.22 [1.1, 1.34] | C-index: 0.649 [0.623, 0.676] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021640 | PGS000805 (GRS582_T2Deur) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.19 [1.08, 1.31] | C-index: 0.646 [0.619, 0.673] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021643 | PGS000729 (T2D_PGS) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.16 [1.05, 1.28] | C-index: 0.642 [0.615, 0.669] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021644 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.15 [1.04, 1.27] | C-index: 0.645 [0.618, 0.672] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021645 | PGS001781 (T2D_PRSCS) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.13 [1.03, 1.25] | C-index: 0.641 [0.613, 0.668] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021647 | PGS000868 (T2D_221) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.13 [1.02, 1.24] | C-index: 0.644 [0.616, 0.671] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021649 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.13 [1.02, 1.24] | C-index: 0.642 [0.616, 0.669] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021650 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.13 [1.02, 1.24] | C-index: 0.642 [0.616, 0.669] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021651 | PGS002026 (portability-ldpred2_250.2) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.12 [1.02, 1.24] | C-index: 0.643 [0.616, 0.67] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021652 | PGS002780 (GTG_T2D_SCT) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.12 [1.01, 1.23] | C-index: 0.644 [0.617, 0.671] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021653 | PGS000014 (GPS_T2D) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.12 [1.01, 1.23] | C-index: 0.641 [0.614, 0.669] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021654 | PGS000713 (T2D) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.12 [1.01, 1.23] | C-index: 0.644 [0.617, 0.671] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021655 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.11 [1.01, 1.23] | C-index: 0.643 [0.615, 0.67] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021656 | PGS000036 (gePS_T2D) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.11 [1.0, 1.22] | C-index: 0.641 [0.614, 0.668] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021657 | PGS002243 (ldpred_t2d) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.1 [1.0, 1.22] | C-index: 0.641 [0.614, 0.668] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021658 | PGS001818 (portability-PLR_250.2) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.09 [0.98, 1.2] | C-index: 0.642 [0.615, 0.669] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021659 | PGS000864 (T2D-gPRS) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 0.94 [0.85, 1.03] | C-index: 0.639 [0.612, 0.667] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021660 | PGS000713 (T2D) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.74 [1.25, 2.41] | C-index: 0.722 [0.646, 0.798] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021661 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.66 [1.19, 2.31] | C-index: 0.713 [0.638, 0.787] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021662 | PGS002771 (Type_2_diabetes_prscs) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.61 [1.14, 2.27] | C-index: 0.697 [0.619, 0.775] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021663 | PGS000330 (PRS_T2D) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.58 [1.13, 2.22] | C-index: 0.695 [0.611, 0.779] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021664 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.57 [1.12, 2.21] | C-index: 0.689 [0.612, 0.765] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021665 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.57 [1.12, 2.21] | C-index: 0.689 [0.612, 0.765] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021666 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.57 [1.12, 2.21] | C-index: 0.689 [0.612, 0.765] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021667 | PGS004923 (T2D_metaGRS) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.43 [1.02, 2.01] | C-index: 0.696 [0.624, 0.767] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021668 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.39 [1.01, 1.92] | C-index: 0.687 [0.612, 0.762] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021669 | PGS000729 (T2D_PGS) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.4 [1.0, 1.95] | C-index: 0.686 [0.611, 0.76] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021670 | PGS000868 (T2D_221) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.37 [0.99, 1.9] | C-index: 0.684 [0.609, 0.758] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021671 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.37 [0.99, 1.89] | C-index: 0.688 [0.612, 0.764] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021672 | PGS002780 (GTG_T2D_SCT) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.31 [0.95, 1.81] | C-index: 0.683 [0.61, 0.755] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021673 | PGS000805 (GRS582_T2Deur) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.28 [0.93, 1.76] | C-index: 0.679 [0.606, 0.753] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021674 | PGS002026 (portability-ldpred2_250.2) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.28 [0.92, 1.77] | C-index: 0.686 [0.609, 0.763] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021675 | PGS001818 (portability-PLR_250.2) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.25 [0.9, 1.73] | C-index: 0.687 [0.616, 0.758] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021676 | PGS001781 (T2D_PRSCS) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.24 [0.9, 1.72] | C-index: 0.685 [0.609, 0.761] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021677 | PGS000014 (GPS_T2D) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.24 [0.9, 1.7] | C-index: 0.684 [0.609, 0.758] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021678 | PGS000036 (gePS_T2D) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.23 [0.89, 1.7] | C-index: 0.68 [0.603, 0.756] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021679 | PGS002243 (ldpred_t2d) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.15 [0.83, 1.58] | C-index: 0.679 [0.606, 0.752] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021682 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.42 [1.3, 1.55] | C-index: 0.639 [0.617, 0.662] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021683 | PGS003445 (PRScsx_T2D_LAT_LATweights) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.42 [1.3, 1.55] | C-index: 0.639 [0.617, 0.662] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021684 | PGS002771 (Type_2_diabetes_prscs) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.35 [1.24, 1.48] | C-index: 0.63 [0.607, 0.652] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021685 | PGS004923 (T2D_metaGRS) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.35 [1.24, 1.48] | C-index: 0.629 [0.606, 0.651] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021686 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.33 [1.22, 1.45] | C-index: 0.627 [0.605, 0.65] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021687 | PGS000330 (PRS_T2D) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.28 [1.17, 1.4] | C-index: 0.622 [0.6, 0.645] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021688 | PGS000805 (GRS582_T2Deur) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.26 [1.16, 1.38] | C-index: 0.617 [0.594, 0.64] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021689 | PGS000713 (T2D) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.26 [1.15, 1.37] | C-index: 0.619 [0.596, 0.641] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021690 | PGS000729 (T2D_PGS) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.24 [1.14, 1.36] | C-index: 0.615 [0.592, 0.638] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021691 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.24 [1.13, 1.35] | C-index: 0.612 [0.589, 0.636] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021692 | PGS000868 (T2D_221) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.24 [1.14, 1.35] | C-index: 0.613 [0.59, 0.637] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021693 | PGS001818 (portability-PLR_250.2) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.24 [1.13, 1.35] | C-index: 0.616 [0.594, 0.639] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021694 | PGS002026 (portability-ldpred2_250.2) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.23 [1.13, 1.35] | C-index: 0.617 [0.595, 0.64] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021695 | PGS002243 (ldpred_t2d) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.17 [1.08, 1.28] | C-index: 0.609 [0.586, 0.632] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021696 | PGS001781 (T2D_PRSCS) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.16 [1.06, 1.27] | C-index: 0.607 [0.584, 0.63] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021697 | PGS001357 (T2D_AnnoPred_PRS) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.15 [1.06, 1.26] | C-index: 0.606 [0.583, 0.629] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021698 | PGS000036 (gePS_T2D) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.15 [1.05, 1.25] | C-index: 0.606 [0.583, 0.629] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021699 | PGS000014 (GPS_T2D) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.14 [1.05, 1.24] | C-index: 0.605 [0.582, 0.628] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021700 | PGS002780 (GTG_T2D_SCT) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.12 [1.03, 1.22] | C-index: 0.603 [0.58, 0.626] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021701 | PGS000864 (T2D-gPRS) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.1 [1.02, 1.2] | C-index: 0.604 [0.58, 0.627] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021410 | PGS004923 (T2D_metaGRS) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Type 2 diabetes | OR: 1.92 [1.88, 1.97] | AUROC: 0.737 [0.732, 0.742] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021412 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.86 [1.82, 1.9] | AUROC: 0.731 [0.726, 0.736] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021430 | PGS002780 (GTG_T2D_SCT) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.46 [1.42, 1.49] | AUROC: 0.694 [0.689, 0.699] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021431 | PGS000864 (T2D-gPRS) |
PSS011737| European Ancestry| 109,021 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.34 [1.32, 1.37] | AUROC: 0.687 [0.682, 0.692] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021440 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011738| European Ancestry| 38,941 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.98 [1.84, 2.13] | C-index: 0.77 [0.754, 0.786] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021472 | PGS003103 (ExPRSweb_T2D_30054458-GCST006867_PRSCS_MGI_20211120) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.28 [1.25, 1.32] | AUROC: 0.721 [0.714, 0.727] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021487 | PGS000864 (T2D-gPRS) |
PSS011735| African Ancestry| 44,346 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.03 [1.0, 1.06] | AUROC: 0.711 [0.705, 0.718] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021488 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011736| Hispanic or Latin American Ancestry| 33,652 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.77 [1.71, 1.84] | AUROC: 0.78 [0.773, 0.786] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021516 | PGS002026 (portability-ldpred2_250.2) |
PSS011740| East Asian Ancestry| 1,149 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.32 [1.13, 1.54] | AUROC: 0.621 [0.579, 0.663] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021537 | PGS000805 (GRS582_T2Deur) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.45 [1.23, 1.72] | AUROC: 0.674 [0.633, 0.716] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021540 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011741| South Asian Ancestry| 852 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.43 [1.21, 1.7] | AUROC: 0.667 [0.626, 0.708] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021558 | PGS004923 (T2D_metaGRS) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.63 [1.37, 1.96] | AUROC: 0.697 [0.655, 0.739] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021563 | PGS000330 (PRS_T2D) |
PSS011739| Additional Asian Ancestries| 870 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | OR: 1.45 [1.22, 1.72] | AUROC: 0.674 [0.632, 0.717] | — | Age at baseline, sex (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021578 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011743| African Ancestry| 6,871 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.4 [1.3, 1.52] | AUROC: 0.723 [0.705, 0.742] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021600 | PGS003444 (PRScsx_T2D_LAT_EASweights) |
PSS011745| East Asian Ancestry| 1,432 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.8 [1.4, 2.32] | AUROC: 0.738 [0.684, 0.791] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021618 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011749| South Asian Ancestry| 6,992 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Type 2 diabetes | OR: 1.91 [1.78, 2.05] | AUROC: 0.746 [0.732, 0.761] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021642 | PGS000330 (PRS_T2D) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.17 [1.06, 1.29] | C-index: 0.646 [0.619, 0.672] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021646 | PGS002671 (disease_T2D.PolyFun-pred) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.13 [1.02, 1.24] | C-index: 0.642 [0.615, 0.67] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021648 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011742| African Ancestry| 6,019 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.13 [1.02, 1.24] | C-index: 0.642 [0.616, 0.669] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
| PPM021680 | PGS000864 (T2D-gPRS) |
PSS011744| East Asian Ancestry| 1,350 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.1 [0.81, 1.5] | C-index: 0.677 [0.604, 0.75] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | — |
| PPM021681 | PGS003443 (PRScsx_T2D_LAT_EURweights) |
PSS011748| South Asian Ancestry| 5,685 individuals |
PGP000656 | Ritchie SC et al. medRxiv (2024) |Ext.|Pre |
Reported Trait: Incident type 2 diabetes | HR: 1.42 [1.3, 1.55] | C-index: 0.639 [0.617, 0.662] | — | Age at baseline, sex assessment centre (PGS adjusted for 20 PCs prior to model fitting) | Note: Performance is based on a linear combination of PGS003443 (weight=0.531117), PGS003444 (weight=0.5690198) and PGS003445 (weight=0.1465538). See score development details for more information |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS011735 | T2D cases were ascertained based on a combination of hospital diagnosis codes, prescription medication, and lab results from blood tests occurring prior to baseline assessment. Participants were considered controls if they had no history of any diabetes diagnoses, T2D medication, or abnormal glucose or HbA1c lab results. Participants with T1D or uncertain diabetes status were excluded from analysis | — | [
|
— | African unspecified | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | AllofUs | — |
| PSS011736 | T2D cases were ascertained based on a combination of hospital diagnosis codes, prescription medication, and lab results from blood tests occurring prior to baseline assessment. Participants were considered controls if they had no history of any diabetes diagnoses, T2D medication, or abnormal glucose or HbA1c lab results. Participants with T1D or uncertain diabetes status were excluded from analysis | — | [
|
— | Hispanic or Latin American | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | AllofUs | — |
| PSS011737 | T2D cases were ascertained based on a combination of hospital diagnosis codes, prescription medication, and lab results from blood tests occurring prior to baseline assessment. Participants were considered controls if they had no history of any diabetes diagnoses, T2D medication, or abnormal glucose or HbA1c lab results. Participants with T1D or uncertain diabetes status were excluded from analysis | — | [
|
— | European | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | AllofUs | — |
| PSS011738 | T2D was defined using ICD-10 codes E10-E14, G59.0, G63.2, H28.0, H36.0, M14.2, N08.3, or O24.0-O24.3. Participants with any diabetes history were excluded from analysis. Incident diabetes events were treated as incident T2D | — | [
|
— | European | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | INTERVAL | — |
| PSS011739 | Incident T2D was ascertained through a combination of linkage to national healthcare records, self-reported medical history at follow-up assessment (either diagnosis from a primary care physician or current diabetes medication usage), or with blood biomarker concentrations indicative of diabetes following the American Diabetes Association criteria (fasting glucose ≥ 7 mmol/L or HbA1c ≥ 6.5% or random blood glucose ≥11 mmol/L) | — | [
|
— | South East Asian (Malay Singaporean) |
Ancestry label assigned based on Malay being the majority reported ethnicity within the genetic cluster | SingaporeMEC | — |
| PSS011740 | Incident T2D was ascertained through a combination of linkage to national healthcare records, self-reported medical history at follow-up assessment (either diagnosis from a primary care physician or current diabetes medication usage), or with blood biomarker concentrations indicative of diabetes following the American Diabetes Association criteria (fasting glucose ≥ 7 mmol/L or HbA1c ≥ 6.5% or random blood glucose ≥11 mmol/L) | — | [
|
— | East Asian (Chinese Singaporean) |
Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | SingaporeMEC | — |
| PSS011741 | Incident T2D was ascertained through a combination of linkage to national healthcare records, self-reported medical history at follow-up assessment (either diagnosis from a primary care physician or current diabetes medication usage), or with blood biomarker concentrations indicative of diabetes following the American Diabetes Association criteria (fasting glucose ≥ 7 mmol/L or HbA1c ≥ 6.5% or random blood glucose ≥11 mmol/L) | — | [
|
— | South Asian (Indian Singaporean) |
Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | SingaporeMEC | — |
| PSS011742 | Prevalent T2D status at baseline was adjudicated from a combination of retrospective hospital episode records, self-reported history of diabetes, and baseline medication using the Eastwood et al. algorithms. Incident T2D cases were ascertained following the Eastwood et al. algorithms on the basis of ICD-10 diagnosis coding E11 in either the hospital inpatient or death registry data | — | [
|
— | African unspecified | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | UKB | — |
| PSS011743 | Prevalent T2D status at baseline was adjudicated from a combination of retrospective hospital episode records, self-reported history of diabetes, and baseline medication using the Eastwood et al. algorithms. Incident T2D cases were ascertained following the Eastwood et al. algorithms on the basis of ICD-10 diagnosis coding E11 in either the hospital inpatient or death registry data | — | [
|
— | African unspecified | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | UKB | — |
| PSS011744 | Prevalent T2D status at baseline was adjudicated from a combination of retrospective hospital episode records, self-reported history of diabetes, and baseline medication using the Eastwood et al. algorithms. Incident T2D cases were ascertained following the Eastwood et al. algorithms on the basis of ICD-10 diagnosis coding E11 in either the hospital inpatient or death registry data | — | [
|
— | East Asian | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | UKB | — |
| PSS011745 | Prevalent T2D status at baseline was adjudicated from a combination of retrospective hospital episode records, self-reported history of diabetes, and baseline medication using the Eastwood et al. algorithms. Incident T2D cases were ascertained following the Eastwood et al. algorithms on the basis of ICD-10 diagnosis coding E11 in either the hospital inpatient or death registry data | — | [
|
— | East Asian | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | UKB | — |
| PSS011746 | Prevalent T2D status at baseline was adjudicated from a combination of retrospective hospital episode records, self-reported history of diabetes, and baseline medication using the Eastwood et al. algorithms. Incident T2D cases were ascertained following the Eastwood et al. algorithms on the basis of ICD-10 diagnosis coding E11 in either the hospital inpatient or death registry data | — | [
|
— | European | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | UKB | — |
| PSS011747 | Prevalent T2D status at baseline was adjudicated from a combination of retrospective hospital episode records, self-reported history of diabetes, and baseline medication using the Eastwood et al. algorithms. Incident T2D cases were ascertained following the Eastwood et al. algorithms on the basis of ICD-10 diagnosis coding E11 in either the hospital inpatient or death registry data | — | [
|
— | European | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | UKB | — |
| PSS011748 | Prevalent T2D status at baseline was adjudicated from a combination of retrospective hospital episode records, self-reported history of diabetes, and baseline medication using the Eastwood et al. algorithms. Incident T2D cases were ascertained following the Eastwood et al. algorithms on the basis of ICD-10 diagnosis coding E11 in either the hospital inpatient or death registry data | — | [
|
— | South Asian | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | UKB | — |
| PSS011749 | Prevalent T2D status at baseline was adjudicated from a combination of retrospective hospital episode records, self-reported history of diabetes, and baseline medication using the Eastwood et al. algorithms. Incident T2D cases were ascertained following the Eastwood et al. algorithms on the basis of ICD-10 diagnosis coding E11 in either the hospital inpatient or death registry data | — | [
|
— | South Asian | Ancestry label assigned based on genetic similarity with 1000 Genomes reference panel superpopulations | UKB | — |