Trait: dermatitis

Trait Information
Identifier MONDO_0002406
Description An inflammatory process affecting the skin. Signs include red rash, itching, and blister formation. Representative examples are contact dermatitis, atopic dermatitis, and seborrheic dermatitis. [NCIT: C2983]
Trait category
Other disease
Synonyms 6 synonyms
  • inflammation of skin
  • inflammation of the skin
  • inflammation of zone of skin
  • inflammatory skin disease
  • skin inflammation
  • zone of skin inflammation
Mapped terms 7 mapped terms
  • DOID:2723
  • ICD9:692.9
  • MEDGEN:849741
  • MESH:D003872
  • NCIT:C2983
  • SCTID:43116000
  • UMLS:C3875321
Child trait(s) 3 child traits

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "dermatitis" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000738
(CONFIRMED_PGS)
 PGP000145 |
Roberts GHL et al. Am J Hum Genet (2019)
 Vitiligo Vitiligo 48
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000738/ScoringFiles/PGS000738.txt.gz
PGS000760
(VIT)
 PGP000164 |
Khan Z et al. Nat Commun (2021)
 Vitiligo Vitiligo 42
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000760/ScoringFiles/PGS000760.txt.gz
PGS000927
(GBE_HC1158)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Other dermatitis (time-to-event) dermatitis 242
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000927/ScoringFiles/PGS000927.txt.gz
PGS000944
(GBE_HC261)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Eczema, dermatitis Eczematoid dermatitis,
dermatitis		 598
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000944/ScoringFiles/PGS000944.txt.gz
PGS001312
(GBE_HC38)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Psoriasis psoriasis 204
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001312/ScoringFiles/PGS001312.txt.gz
PGS001313
(GBE_HC1159)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Psoriasis (time-to-event) psoriasis 578
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001313/ScoringFiles/PGS001313.txt.gz
PGS001536
(GBE_HC1188)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Vitiligo (time-to-event) Vitiligo 77
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001536/ScoringFiles/PGS001536.txt.gz
PGS001773
(PRS_atopicDermatitis)
 PGP000253 |
Simard M et al. J Allergy Clin Immunol (2020)
 Moderate-to-severe atopic dermatitis atopic eczema 25
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001773/ScoringFiles/PGS001773.txt.gz
PGS001871
(portability-PLR_696.4)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Psoriasis psoriasis 264
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001871/ScoringFiles/PGS001871.txt.gz
PGS002083
(portability-ldpred2_696.4)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Psoriasis psoriasis 71,744
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002083/ScoringFiles/PGS002083.txt.gz
PGS002293
(PRS62_psoriasis)
 PGP000323 |
Shen M et al. J Am Acad Dermatol (2022)
 Psoriasis psoriasis 62
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002293/ScoringFiles/PGS002293.txt.gz
PGS002344
(disease_PSORIASIS.BOLT-LMM)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Psoriasis psoriasis 1,109,311
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002344/ScoringFiles/PGS002344.txt.gz
PGS002416
(disease_PSORIASIS.P+T.0.0001)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Psoriasis psoriasis 6,879
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002416/ScoringFiles/PGS002416.txt.gz
PGS002465
(disease_PSORIASIS.P+T.0.001)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Psoriasis psoriasis 21,483
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002465/ScoringFiles/PGS002465.txt.gz
PGS002514
(disease_PSORIASIS.P+T.0.01)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Psoriasis psoriasis 96,453
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002514/ScoringFiles/PGS002514.txt.gz
PGS002563
(disease_PSORIASIS.P+T.1e-06)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Psoriasis psoriasis 1,348
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002563/ScoringFiles/PGS002563.txt.gz
PGS002612
(disease_PSORIASIS.P+T.5e-08)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Psoriasis psoriasis 643
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002612/ScoringFiles/PGS002612.txt.gz
PGS002661
(disease_PSORIASIS.PolyFun-pred)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Psoriasis psoriasis 283,128
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002661/ScoringFiles/PGS002661.txt.gz
PGS002710
(disease_PSORIASIS.SBayesR)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Psoriasis psoriasis 566,839
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002710/ScoringFiles/PGS002710.txt.gz
PGS002755
(Atopic_dermatitis_prscs)
 PGP000364 |
Mars N et al. Am J Hum Genet (2022)
 Atopic dermatitis atopic eczema 1,090,702
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002755/ScoringFiles/PGS002755.txt.gz
PGS003459
(PRS_CO)
 PGP000451 |
Al-Janabi A et al. J Invest Dermatol (2023)
 Atopic eczema or atopic disease atopic eczema,
allergic disease		 170
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003459/ScoringFiles/PGS003459.txt.gz
PGS003486
(PRS_AE)
 PGP000451 |
Al-Janabi A et al. J Invest Dermatol (2023)
 Atopic eczema atopic eczema 71
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003486/ScoringFiles/PGS003486.txt.gz
PGS004260
(GenoBoost_psoriasis_0)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Psoriasis psoriasis 900
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004260/ScoringFiles/PGS004260.txt.gz
PGS004261
(GenoBoost_psoriasis_1)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Psoriasis psoriasis 800
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004261/ScoringFiles/PGS004261.txt.gz
PGS004262
(GenoBoost_psoriasis_2)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Psoriasis psoriasis 200
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004262/ScoringFiles/PGS004262.txt.gz
PGS004263
(GenoBoost_psoriasis_3)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Psoriasis psoriasis 800
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004263/ScoringFiles/PGS004263.txt.gz
PGS004264
(GenoBoost_psoriasis_4)
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Psoriasis psoriasis 110
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004264/ScoringFiles/PGS004264.txt.gz
PGS004315
(GRS-ALL)
 PGP000547 |
Bui A et al. Front Genet (2023)
 Psoriasis psoriasis 88
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004315/ScoringFiles/PGS004315.txt.gz
PGS004316
(GRS-HLA)
 PGP000547 |
Bui A et al. Front Genet (2023)
 Psoriasis psoriasis 11
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004316/ScoringFiles/PGS004316.txt.gz
PGS004317
(GRS-noHLA)
 PGP000547 |
Bui A et al. Front Genet (2023)
 Psoriasis psoriasis 77
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004317/ScoringFiles/PGS004317.txt.gz
PGS004587
(PRS23_AD)
 PGP000566 |
Gu X et al. Ecotoxicol Environ Saf (2023)
 Atopic dermatitis atopic eczema 23
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004587/ScoringFiles/PGS004587.txt.gz
PGS004903
(PRS_ALL)
 PGP000633 |
Al-Janabi A et al. J Allergy Clin Immunol (2023)
 Atopic dermatitis atopic eczema 38
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004903/ScoringFiles/PGS004903.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001761 PGS000738
(CONFIRMED_PGS)
 PSS000907|
European Ancestry|
4,008 individuals
 PGP000145 |
Roberts GHL et al. Am J Hum Genet (2019)
 Reported Trait: Vitiligo — — Odds Ratio (OR, top 20% vs remaining 80% of score distribution): 4.87 [4.21, 5.64] — —
PPM001762 PGS000738
(CONFIRMED_PGS)
 PSS000907|
European Ancestry|
4,008 individuals
 PGP000145 |
Roberts GHL et al. Am J Hum Genet (2019)
 Reported Trait: Vitiligo — — Odds Ratio (OR, top 10% vs remaining 90% of score distribution): 5.26 [4.42, 6.29] — —
PPM001763 PGS000738
(CONFIRMED_PGS)
 PSS000907|
European Ancestry|
4,008 individuals
 PGP000145 |
Roberts GHL et al. Am J Hum Genet (2019)
 Reported Trait: Vitiligo — — Odds Ratio (OR, top 10% vs remaining 95% of score distribution): 6.2 [4.96, 7.79] — —
PPM001764 PGS000738
(CONFIRMED_PGS)
 PSS000907|
European Ancestry|
4,008 individuals
 PGP000145 |
Roberts GHL et al. Am J Hum Genet (2019)
 Reported Trait: Vitiligo — — Odds Ratio (OR, top 1% vs remaining 99% of score distribution): 8.79 [5.85, 13.78] — —
PPM018437 PGS000738
(CONFIRMED_PGS)
 PSS010969|
European Ancestry|
4,945 individuals
 PGP000467 |
Farré X et al. Genes (Basel) (2023)
|Ext.		 Reported Trait: Fitzpatrick scale β: 0.02234 — R²: 0.02897 — —
PPM018438 PGS000738
(CONFIRMED_PGS)
 PSS010968|
European Ancestry|
4,702 individuals
 PGP000467 |
Farré X et al. Genes (Basel) (2023)
|Ext.		 Reported Trait: Red hair β: 0.69478 — pseudo R²: 0.03857 — —
PPM018435 PGS000738
(CONFIRMED_PGS)
 PSS010977|
European Ancestry|
4,987 individuals
 PGP000467 |
Farré X et al. Genes (Basel) (2023)
|Ext.		 Reported Trait: Freckles β: -0.04382 — R²: 0.02103 — —
PPM018436 PGS000738
(CONFIRMED_PGS)
 PSS010974|
European Ancestry|
4,979 individuals
 PGP000467 |
Farré X et al. Genes (Basel) (2023)
|Ext.		 Reported Trait: Phototype score β: 0.4039 — R²: 0.03252 — —
PPM001935 PGS000760
(VIT)
 PSS000970|
European Ancestry|
1,584 individuals
 PGP000164 |
Khan Z et al. Nat Commun (2021)
 Reported Trait: anti-PD-L1 induced hypothyroidism in cancer patients HR: 1.41 [1.22, 1.61] — meta-analysis p-value: 1.10e-06 5 genotype PCs —
PPM007462 PGS000927
(GBE_HC1158)
 PSS004153|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE other dermatitis — AUROC: 0.61027 [0.57953, 0.64101] R²: 0.02035
Incremental AUROC (full-covars): 0.00207
PGS R2 (no covariates): 0.00268
PGS AUROC (no covariates): 0.5378 [0.50673, 0.56886]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007463 PGS000927
(GBE_HC1158)
 PSS004154|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE other dermatitis — AUROC: 0.57706 [0.52927, 0.62486] R²: 0.02951
Incremental AUROC (full-covars): 0.01147
PGS R2 (no covariates): 0.00458
PGS AUROC (no covariates): 0.5429 [0.49389, 0.59191]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007464 PGS000927
(GBE_HC1158)
 PSS004155|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE other dermatitis — AUROC: 0.54587 [0.53304, 0.5587] R²: 0.00506
Incremental AUROC (full-covars): 0.01785
PGS R2 (no covariates): 0.00339
PGS AUROC (no covariates): 0.53939 [0.52639, 0.55239]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007465 PGS000927
(GBE_HC1158)
 PSS004156|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE other dermatitis — AUROC: 0.58261 [0.56273, 0.60248] R²: 0.01573
Incremental AUROC (full-covars): 0.00482
PGS R2 (no covariates): 0.00187
PGS AUROC (no covariates): 0.52627 [0.50591, 0.54663]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007466 PGS000927
(GBE_HC1158)
 PSS004157|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE other dermatitis — AUROC: 0.56752 [0.56014, 0.57491] R²: 0.01047
Incremental AUROC (full-covars): 0.01697
PGS R2 (no covariates): 0.00542
PGS AUROC (no covariates): 0.54889 [0.54154, 0.55624]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007546 PGS000944
(GBE_HC261)
 PSS004384|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Eczema/dermatitis — AUROC: 0.62856 [0.58377, 0.67334] R²: 0.02337
Incremental AUROC (full-covars): 0.00187
PGS R2 (no covariates): 0.00173
PGS AUROC (no covariates): 0.52778 [0.48039, 0.57516]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007547 PGS000944
(GBE_HC261)
 PSS004385|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Eczema/dermatitis — AUROC: 0.59588 [0.52553, 0.66622] R²: 0.02855
Incremental AUROC (full-covars): 0.02432
PGS R2 (no covariates): 0.0116
PGS AUROC (no covariates): 0.58664 [0.52213, 0.65115]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007548 PGS000944
(GBE_HC261)
 PSS004386|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Eczema/dermatitis — AUROC: 0.56459 [0.54541, 0.58377] R²: 0.00802
Incremental AUROC (full-covars): 0.01208
PGS R2 (no covariates): 0.00353
PGS AUROC (no covariates): 0.54597 [0.52632, 0.56561]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007549 PGS000944
(GBE_HC261)
 PSS004387|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Eczema/dermatitis — AUROC: 0.56106 [0.52439, 0.59773] R²: 0.00683
Incremental AUROC (full-covars): -0.0012
PGS R2 (no covariates): 0.00011
PGS AUROC (no covariates): 0.51686 [0.48122, 0.5525]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007550 PGS000944
(GBE_HC261)
 PSS004388|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Eczema/dermatitis — AUROC: 0.57099 [0.55943, 0.58256] R²: 0.00884
Incremental AUROC (full-covars): 0.02521
PGS R2 (no covariates): 0.00527
PGS AUROC (no covariates): 0.5556 [0.54396, 0.56724]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009053 PGS001312
(GBE_HC38)
 PSS004471|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Psoriasis — AUROC: 0.73107 [0.60624, 0.85591] R²: 0.06593
Incremental AUROC (full-covars): 0.0282
PGS R2 (no covariates): 0.01927
PGS AUROC (no covariates): 0.62557 [0.48848, 0.76266]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009054 PGS001312
(GBE_HC38)
 PSS004472|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Psoriasis — AUROC: 0.88867 [0.80531, 0.97202] R²: 0.24575
Incremental AUROC (full-covars): 0.01187
PGS R2 (no covariates): 0.00399
PGS AUROC (no covariates): 0.57774 [0.40533, 0.75016]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009055 PGS001312
(GBE_HC38)
 PSS004473|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Psoriasis — AUROC: 0.68424 [0.65757, 0.71091] R²: 0.05057
Incremental AUROC (full-covars): 0.0981
PGS R2 (no covariates): 0.04137
PGS AUROC (no covariates): 0.66409 [0.63596, 0.69222]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009056 PGS001312
(GBE_HC38)
 PSS004474|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Psoriasis — AUROC: 0.6849 [0.63397, 0.73584] R²: 0.0448
Incremental AUROC (full-covars): 0.052
PGS R2 (no covariates): 0.02087
PGS AUROC (no covariates): 0.64825 [0.59861, 0.6979]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009057 PGS001312
(GBE_HC38)
 PSS004475|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Psoriasis — AUROC: 0.69754 [0.68165, 0.71343] R²: 0.05574
Incremental AUROC (full-covars): 0.14505
PGS R2 (no covariates): 0.05226
PGS AUROC (no covariates): 0.69158 [0.6754, 0.70775]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009058 PGS001313
(GBE_HC1159)
 PSS004158|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE psoriasis — AUROC: 0.69906 [0.60273, 0.7954] R²: 0.04185
Incremental AUROC (full-covars): 0.01899
PGS R2 (no covariates): 0.00732
PGS AUROC (no covariates): 0.62223 [0.54291, 0.70154]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009059 PGS001313
(GBE_HC1159)
 PSS004159|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE psoriasis — AUROC: 0.72306 [0.61623, 0.82989] R²: 0.09162
Incremental AUROC (full-covars): 0.00222
PGS R2 (no covariates): 0.00378
PGS AUROC (no covariates): 0.48492 [0.37014, 0.5997]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009060 PGS001313
(GBE_HC1159)
 PSS004160|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE psoriasis — AUROC: 0.66545 [0.64532, 0.68558] R²: 0.04468
Incremental AUROC (full-covars): 0.07449
PGS R2 (no covariates): 0.0337
PGS AUROC (no covariates): 0.64565 [0.62471, 0.66658]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009061 PGS001313
(GBE_HC1159)
 PSS004161|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE psoriasis — AUROC: 0.63418 [0.59417, 0.67419] R²: 0.0236
Incremental AUROC (full-covars): 0.05154
PGS R2 (no covariates): 0.0123
PGS AUROC (no covariates): 0.60455 [0.56482, 0.64428]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009062 PGS001313
(GBE_HC1159)
 PSS004162|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE psoriasis — AUROC: 0.67543 [0.66285, 0.68801] R²: 0.05117
Incremental AUROC (full-covars): 0.13853
PGS R2 (no covariates): 0.04966
PGS AUROC (no covariates): 0.6729 [0.66027, 0.68553]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005215 PGS001536
(GBE_HC1188)
 PSS004173|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE vitiligo — AUROC: 0.63509 [0.52563, 0.74454] R²: 0.01654
Incremental AUROC (full-covars): -0.00281
PGS R2 (no covariates): 0.0
PGS AUROC (no covariates): 0.51169 [0.39527, 0.62811]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005216 PGS001536
(GBE_HC1188)
 PSS004174|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE vitiligo — AUROC: 0.82774 [0.75298, 0.90249] R²: 0.08055
Incremental AUROC (full-covars): 0.01924
PGS R2 (no covariates): 0.00431
PGS AUROC (no covariates): 0.57823 [0.37976, 0.7767]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005217 PGS001536
(GBE_HC1188)
 PSS004175|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE vitiligo — AUROC: 0.6991 [0.61917, 0.77902] R²: 0.03993
Incremental AUROC (full-covars): 0.01341
PGS R2 (no covariates): 0.00254
PGS AUROC (no covariates): 0.55625 [0.47549, 0.63701]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005218 PGS001536
(GBE_HC1188)
 PSS004176|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE vitiligo — AUROC: 0.64566 [0.58746, 0.70386] R²: 0.02575
Incremental AUROC (full-covars): 0.0309
PGS R2 (no covariates): 0.01048
PGS AUROC (no covariates): 0.60302 [0.5391, 0.66694]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005219 PGS001536
(GBE_HC1188)
 PSS004177|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE vitiligo — AUROC: 0.63449 [0.58754, 0.68144] R²: 0.01686
Incremental AUROC (full-covars): 0.08163
PGS R2 (no covariates): 0.01621
PGS AUROC (no covariates): 0.64193 [0.59907, 0.68478]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009229 PGS001773
(PRS_atopicDermatitis)
 PSS007661|
Multi-ancestry (including European)|
676 individuals
 PGP000253 |
Simard M et al. J Allergy Clin Immunol (2020)
 Reported Trait: Moderate-to-severe aotpic dermatitis — AUROC: 0.93 R²: 0.49 Age, sex, father's ethnicity, mother ethnicity Nagelkerke's R^2, only unrelated individuals were considered in the analyses
PPM009230 PGS001773
(PRS_atopicDermatitis)
 PSS007661|
Multi-ancestry (including European)|
676 individuals
 PGP000253 |
Simard M et al. J Allergy Clin Immunol (2020)
 Reported Trait: Food allergy — AUROC: 0.75 — Age, sex, father's ethnicity, mother ethnicity Only unrelated individuals were considered in the analyses
PPM009231 PGS001773
(PRS_atopicDermatitis)
 PSS007661|
Multi-ancestry (including European)|
676 individuals
 PGP000253 |
Simard M et al. J Allergy Clin Immunol (2020)
 Reported Trait: Allergic asthma — AUROC: 0.75 — Age, sex, father's ethnicity, mother ethnicity Only unrelated individuals were considered in the analyses
PPM009232 PGS001773
(PRS_atopicDermatitis)
 PSS007661|
Multi-ancestry (including European)|
676 individuals
 PGP000253 |
Simard M et al. J Allergy Clin Immunol (2020)
 Reported Trait: Allergic rhinitis — AUROC: 0.77 — Age, sex, father's ethnicity, mother ethnicity Only unrelated individuals were considered in the analyses
PPM009857 PGS001871
(portability-PLR_696.4)
 PSS009347|
European Ancestry|
19,615 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0636 [0.0497, 0.0775] sex, age, birth date, deprivation index, 16 PCs —
PPM009858 PGS001871
(portability-PLR_696.4)
 PSS009121|
European Ancestry|
4,059 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.107 [0.0764, 0.1374] sex, age, birth date, deprivation index, 16 PCs —
PPM009859 PGS001871
(portability-PLR_696.4)
 PSS008675|
European Ancestry|
6,554 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0404 [0.0162, 0.0646] sex, age, birth date, deprivation index, 16 PCs —
PPM009860 PGS001871
(portability-PLR_696.4)
 PSS008449|
Greater Middle Eastern Ancestry|
1,183 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0463 [-0.0112, 0.1035] sex, age, birth date, deprivation index, 16 PCs —
PPM009861 PGS001871
(portability-PLR_696.4)
 PSS008229|
South Asian Ancestry|
6,161 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0327 [0.0077, 0.0577] sex, age, birth date, deprivation index, 16 PCs —
PPM009862 PGS001871
(portability-PLR_696.4)
 PSS008010|
East Asian Ancestry|
1,784 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0079 [-0.0388, 0.0545] sex, age, birth date, deprivation index, 16 PCs —
PPM009863 PGS001871
(portability-PLR_696.4)
 PSS007794|
African Ancestry|
2,398 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0357 [-0.0045, 0.0757] sex, age, birth date, deprivation index, 16 PCs —
PPM009864 PGS001871
(portability-PLR_696.4)
 PSS008898|
African Ancestry|
3,834 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): -0.0065 [-0.0382, 0.0252] sex, age, birth date, deprivation index, 16 PCs —
PPM011525 PGS002083
(portability-ldpred2_696.4)
 PSS009347|
European Ancestry|
19,615 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0632 [0.0493, 0.0771] sex, age, birth date, deprivation index, 16 PCs —
PPM011526 PGS002083
(portability-ldpred2_696.4)
 PSS009121|
European Ancestry|
4,059 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.1153 [0.0847, 0.1456] sex, age, birth date, deprivation index, 16 PCs —
PPM011527 PGS002083
(portability-ldpred2_696.4)
 PSS008675|
European Ancestry|
6,554 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.041 [0.0168, 0.0652] sex, age, birth date, deprivation index, 16 PCs —
PPM011529 PGS002083
(portability-ldpred2_696.4)
 PSS008229|
South Asian Ancestry|
6,161 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.03 [0.005, 0.055] sex, age, birth date, deprivation index, 16 PCs —
PPM011530 PGS002083
(portability-ldpred2_696.4)
 PSS008010|
East Asian Ancestry|
1,784 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0119 [-0.0348, 0.0585] sex, age, birth date, deprivation index, 16 PCs —
PPM011531 PGS002083
(portability-ldpred2_696.4)
 PSS007794|
African Ancestry|
2,398 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0375 [-0.0027, 0.0776] sex, age, birth date, deprivation index, 16 PCs —
PPM011532 PGS002083
(portability-ldpred2_696.4)
 PSS008898|
African Ancestry|
3,834 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): -0.0166 [-0.0483, 0.0152] sex, age, birth date, deprivation index, 16 PCs —
PPM011528 PGS002083
(portability-ldpred2_696.4)
 PSS008449|
Greater Middle Eastern Ancestry|
1,183 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0458 [-0.0117, 0.1031] sex, age, birth date, deprivation index, 16 PCs —
PPM013020 PGS002293
(PRS62_psoriasis)
 PSS009651|
European Ancestry|
345,672 individuals
 PGP000323 |
Shen M et al. J Am Acad Dermatol (2022)
 Reported Trait: Incident psoriasis HR: 4.625 [2.92, 7.348] — Odds Ratio (OR, poor lifestyle and high genetic risk): 4.625 [2.92, 7.348]
Population-attributable fraction of genetic risk: 0.13 [0.032, 0.218]		 Age, sex, education, Townsend Index, and region, relatedness, number of alleles included in the polygenic risk score, and first 20 principal components of ancestry —
PPM013109 PGS002344
(disease_PSORIASIS.BOLT-LMM)
 PSS009819|
African Ancestry|
6,503 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013158 PGS002344
(disease_PSORIASIS.BOLT-LMM)
 PSS009820|
East Asian Ancestry|
922 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013207 PGS002344
(disease_PSORIASIS.BOLT-LMM)
 PSS009821|
European Ancestry|
43,505 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.007 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013256 PGS002344
(disease_PSORIASIS.BOLT-LMM)
 PSS009822|
South Asian Ancestry|
8,098 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0035 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013397 PGS002416
(disease_PSORIASIS.P+T.0.0001)
 PSS009819|
African Ancestry|
6,503 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0005 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013446 PGS002416
(disease_PSORIASIS.P+T.0.0001)
 PSS009820|
East Asian Ancestry|
922 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013495 PGS002416
(disease_PSORIASIS.P+T.0.0001)
 PSS009821|
European Ancestry|
43,505 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013544 PGS002416
(disease_PSORIASIS.P+T.0.0001)
 PSS009822|
South Asian Ancestry|
8,098 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013593 PGS002465
(disease_PSORIASIS.P+T.0.001)
 PSS009819|
African Ancestry|
6,503 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0003 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013642 PGS002465
(disease_PSORIASIS.P+T.0.001)
 PSS009820|
East Asian Ancestry|
922 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013691 PGS002465
(disease_PSORIASIS.P+T.0.001)
 PSS009821|
European Ancestry|
43,505 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013740 PGS002465
(disease_PSORIASIS.P+T.0.001)
 PSS009822|
South Asian Ancestry|
8,098 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013789 PGS002514
(disease_PSORIASIS.P+T.0.01)
 PSS009819|
African Ancestry|
6,503 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0003 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013838 PGS002514
(disease_PSORIASIS.P+T.0.01)
 PSS009820|
East Asian Ancestry|
922 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013887 PGS002514
(disease_PSORIASIS.P+T.0.01)
 PSS009821|
European Ancestry|
43,505 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013936 PGS002514
(disease_PSORIASIS.P+T.0.01)
 PSS009822|
South Asian Ancestry|
8,098 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013985 PGS002563
(disease_PSORIASIS.P+T.1e-06)
 PSS009819|
African Ancestry|
6,503 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0004 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014034 PGS002563
(disease_PSORIASIS.P+T.1e-06)
 PSS009820|
East Asian Ancestry|
922 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014083 PGS002563
(disease_PSORIASIS.P+T.1e-06)
 PSS009821|
European Ancestry|
43,505 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014132 PGS002563
(disease_PSORIASIS.P+T.1e-06)
 PSS009822|
South Asian Ancestry|
8,098 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014181 PGS002612
(disease_PSORIASIS.P+T.5e-08)
 PSS009819|
African Ancestry|
6,503 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0007 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014230 PGS002612
(disease_PSORIASIS.P+T.5e-08)
 PSS009820|
East Asian Ancestry|
922 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014279 PGS002612
(disease_PSORIASIS.P+T.5e-08)
 PSS009821|
European Ancestry|
43,505 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014328 PGS002612
(disease_PSORIASIS.P+T.5e-08)
 PSS009822|
South Asian Ancestry|
8,098 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014377 PGS002661
(disease_PSORIASIS.PolyFun-pred)
 PSS009819|
African Ancestry|
6,503 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_PSORIASIS.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014426 PGS002661
(disease_PSORIASIS.PolyFun-pred)
 PSS009820|
East Asian Ancestry|
922 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_PSORIASIS.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014475 PGS002661
(disease_PSORIASIS.PolyFun-pred)
 PSS009821|
European Ancestry|
43,505 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.007 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_PSORIASIS.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014524 PGS002661
(disease_PSORIASIS.PolyFun-pred)
 PSS009822|
South Asian Ancestry|
8,098 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0034 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_PSORIASIS.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014622 PGS002710
(disease_PSORIASIS.SBayesR)
 PSS009820|
East Asian Ancestry|
922 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014671 PGS002710
(disease_PSORIASIS.SBayesR)
 PSS009821|
European Ancestry|
43,505 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0014 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014720 PGS002710
(disease_PSORIASIS.SBayesR)
 PSS009822|
South Asian Ancestry|
8,098 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014573 PGS002710
(disease_PSORIASIS.SBayesR)
 PSS009819|
African Ancestry|
6,503 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Psoriasis — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014955 PGS002755
(Atopic_dermatitis_prscs)
 PSS009939|
European Ancestry|
39,444 individuals
 PGP000364 |
Mars N et al. Am J Hum Genet (2022)
 Reported Trait: Atopic dermatitis OR: 1.28 [1.21, 1.34] — — age, sex, 10 PCs, technical covariates —
PPM020709 PGS002755
(Atopic_dermatitis_prscs)
 PSS011376|
European Ancestry|
337,910 individuals
 PGP000566 |
Gu X et al. Ecotoxicol Environ Saf (2023)
|Ext.		 Reported Trait: Incident atopic dermatitis — — Hazard ratio (HR, high vs low PRS): 1.249 [1.123, 1.391] sex, age, Townsend index, moderate physical and household income —
PPM020710 PGS002755
(Atopic_dermatitis_prscs)
 PSS011376|
European Ancestry|
337,910 individuals
 PGP000566 |
Gu X et al. Ecotoxicol Environ Saf (2023)
|Ext.		 Reported Trait: Incident atopic dermatitis with air pollution level — — Hazard ratio (HR, high air pollution and high PRS vs low air pollution and low PRS): 1.978 [1.624, 2.411] sex, age, Townsend index, moderate physical and household income —
PPM017414 PGS003459
(PRS_CO)
 PSS010186|
European Ancestry|
3,212 individuals
 PGP000451 |
Al-Janabi A et al. J Invest Dermatol (2023)
 Reported Trait: Paradoxical eczema in biologic-treated psoriasis OR: 1.83 [1.17, 2.84] AUROC: 0.585 — PCs 1-2 —
PPM017412 PGS003486
(PRS_AE)
 PSS010186|
European Ancestry|
3,212 individuals
 PGP000451 |
Al-Janabi A et al. J Invest Dermatol (2023)
 Reported Trait: Paradoxical eczema in biologic-treated psoriasis OR: 1.89 [1.08, 3.3] AUROC: 0.567 — PCs 1-2 —
PPM020328 PGS004260
(GenoBoost_psoriasis_0)
 PSS011347|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Psoriasis — AUROC: 0.66908 Covariate-adjusted pseudo-R2: 0.04239
AUPRC: 0.04468		 age, sex, PC1-10 —
PPM020329 PGS004261
(GenoBoost_psoriasis_1)
 PSS011347|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Psoriasis — AUROC: 0.67722 Covariate-adjusted pseudo-R2: 0.04563
AUPRC: 0.0457		 age, sex, PC1-10 —
PPM020330 PGS004262
(GenoBoost_psoriasis_2)
 PSS011347|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Psoriasis — AUROC: 0.66916 Covariate-adjusted pseudo-R2: 0.04211
AUPRC: 0.0431		 age, sex, PC1-10 —
PPM020331 PGS004263
(GenoBoost_psoriasis_3)
 PSS011347|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Psoriasis — AUROC: 0.67205 Covariate-adjusted pseudo-R2: 0.04423
AUPRC: 0.04681		 age, sex, PC1-10 —
PPM020332 PGS004264
(GenoBoost_psoriasis_4)
 PSS011347|
European Ancestry|
67,428 individuals
 PGP000546 |
Ohta R et al. Nat Commun (2024)
 Reported Trait: Psoriasis — AUROC: 0.66842 Covariate-adjusted pseudo-R2: 0.04356
AUPRC: 0.04551		 age, sex, PC1-10 —
PPM020383 PGS004315
(GRS-ALL)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Family history of psoriasis OR: 1.02 [1.0, 1.04] — R²: 0.0067 — —
PPM020384 PGS004315
(GRS-ALL)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Age of psoriasis onset OR: 0.71 [0.59, 0.85] — R²: 0.023 — —
PPM020386 PGS004315
(GRS-ALL)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Age of type1 psoriasis onset OR: 0.82 [0.59, 0.85] — R²: 0.0206 — —
PPM020388 PGS004315
(GRS-ALL)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Psoriasis severity OR: 1.02 [1.0, 1.06] — R²: 0.061 — —
PPM020390 PGS004315
(GRS-ALL)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Total number of locations ever affected by psoriasis OR: 1.16 [1.11, 1.21] — R²: 0.061 — —
PPM020393 PGS004315
(GRS-ALL)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Initial presentation of psoriasis at elbow or knee OR: 0.97 [0.94, 0.99] — — — —
PPM020396 PGS004315
(GRS-ALL)
 PSS011348|
European Ancestry|
345 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Psoriasis in genital area β: -0.037 (0.016) — — — —
PPM020385 PGS004316
(GRS-HLA)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Age of psoriasis onset OR: 0.46 [0.34, 0.63] — R²: 0.0398 — —
PPM020387 PGS004316
(GRS-HLA)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Age of type1 psoriasis onset OR: 0.69 [0.56, 0.86] — R²: 0.0216 — —
PPM020389 PGS004316
(GRS-HLA)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Psoriasis severity OR: 1.09 [1.03, 1.15] — R²: 0.077 — —
PPM020391 PGS004316
(GRS-HLA)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Total number of locations ever affected by psoriasis OR: 1.34 [1.24, 1.45] — R²: 0.077 — —
PPM020394 PGS004316
(GRS-HLA)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Initial presentation of psoriasis at elbow or knee OR: 0.92 [0.88, 0.96] — — — —
PPM020392 PGS004317
(GRS-noHLA)
 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Psoriasis in genital area OR: 0.97 [0.94, 1.0] — — — —
PPM020395 PGS004317
(GRS-noHLA)
 PSS011348|
European Ancestry|
345 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Psoriasis in genital area β: -0.038 (0.019) — — — —
PPM020707 PGS004587
(PRS23_AD)
 PSS011376|
European Ancestry|
337,910 individuals
 PGP000566 |
Gu X et al. Ecotoxicol Environ Saf (2023)
 Reported Trait: Incident atopic dermatitis — — Hazard ratio (HR, high vs low PRS): 1.153 [1.037, 1.282] sex, age, Townsend index, moderate physical and household income —
PPM020708 PGS004587
(PRS23_AD)
 PSS011376|
European Ancestry|
337,910 individuals
 PGP000566 |
Gu X et al. Ecotoxicol Environ Saf (2023)
 Reported Trait: Incident atopic dermatitis with air pollution level — — Hazard ratio (HR, high air pollution and high PRS vs low air pollution and low PRS): 1.523 [1.259, 1.84] sex, age, Townsend index, moderate physical and household income —
PPM021335 PGS004903
(PRS_ALL)
 PSS011691|
European Ancestry|
3,212 individuals
 PGP000633 |
Al-Janabi A et al. J Allergy Clin Immunol (2023)
 Reported Trait: Paradoxical eczema in individuals with psoriasis — — Coefficient: 4.77 [0.58, 8.96]
p: 0.026		 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004156 — —
[
  • 850 cases
  • , 6,981 controls
]
 — South Asian — UKB —
PSS004157 — —
[
  • 6,461 cases
  • , 60,964 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS004158 — —
[
  • 32 cases
  • , 6,465 controls
]
 — African unspecified — UKB —
PSS004159 — —
[
  • 22 cases
  • , 1,682 controls
]
 — East Asian — UKB —
PSS004160 — —
[
  • 723 cases
  • , 24,182 controls
]
 — European non-white British ancestry UKB —
PSS004161 — —
[
  • 186 cases
  • , 7,645 controls
]
 — South Asian — UKB —
PSS004162 — —
[
  • 1,956 cases
  • , 65,469 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS008010 — — 1,784 individuals — East Asian China (East Asia) UKB —
PSS011691 — —
[
  • 88 cases
  • , 3,124 controls
]
 — European — BSTOP —
PSS004173 — —
[
  • 17 cases
  • , 6,480 controls
]
 — African unspecified — UKB —
PSS004174 — —
[
  • 6 cases
  • , 1,698 controls
]
 — East Asian — UKB —
PSS004175 — —
[
  • 45 cases
  • , 24,860 controls
]
 — European non-white British ancestry UKB —
PSS004176 — —
[
  • 71 cases
  • , 7,760 controls
]
 — South Asian — UKB —
PSS004177 — —
[
  • 131 cases
  • , 67,294 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS000907 Cases are individuals with vitiligo. Diagnoses of vitiligo in multiplex-affected subjects and reportedly unaffected family members were verified by manual review of all available phenotype information for each subject. —
[
  • 1,827 cases
  • , 2,181 controls
]
 — European — NR —
PSS008675 — — 6,554 individuals — European Italy (South Europe) UKB —
PSS007794 — — 2,398 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008898 — — 3,834 individuals — African unspecified Nigeria (West Africa) UKB —
PSS007661 For the CHILD Cohort Study, atopic dermatitis (AD) was from physician diagnosis at the one year follow-up. AD severity was defined as mild if there is a single site or no more than 2 sites, minor symptoms (little itching/rubbing), minor crusting and papules, not excoriated or oozing, not needing frequent medical attention; was defined as moderate if symptoms are neither mild nor severe or; was defined as severe if there are multiple sites, with extensive crusting or papules or excoriations or oozing or lichenification, sleep loss, needing frequent medical attention, and is a major concern to parents. In the SLSJ Cohort, atopic dermatitis was self-reported and considered as positive if past or present occurrence was reported. For children, cross validation was done using questionnaires filled by their parents. Moreover, validation in medical records of these self-reported phenotypes were done for a subset of the SLSJ Cohort (n = 217), giving 89% concordance. —
[
  • 61 cases
  • , 615 controls
]
,
42.0 % Male samples
 Mean = 9.0 years
Range = [0.0, 87.0] years		 European, South East Asian, East Asian, South Asian, African American or Afro-Caribbean, Native American, Greater Middle Eastern (Middle Eastern, North African or Persian), Hispanic or Latin American, Not reported — CHILD, SLSJ Also used to evaluate the PRS_atopicDermatitis for other diseases of the atopic march: food allergy, allergic asthma and rhinitis. Only unrelated individuals were selected for analyses.
PSS011347 — —
[
  • 1,277 cases
  • , 66,151 controls
]
,
46.0 % Male samples
 — European
(White British)		 — UKB —
PSS011348 — — 345 individuals,
52.0 % Male samples
 Mean = 49.0 years
Sd = 16.0 years		 European — UCSF —
PSS011349 — — 654 individuals,
48.0 % Male samples
 Mean = 41.0 years
Sd = 14.0 years		 European — NR —
PSS004471 — —
[
  • 19 cases
  • , 6,478 controls
]
 — African unspecified — UKB —
PSS004472 — —
[
  • 10 cases
  • , 1,694 controls
]
 — East Asian — UKB —
PSS004473 — —
[
  • 416 cases
  • , 24,489 controls
]
 — European non-white British ancestry UKB —
PSS004474 — —
[
  • 108 cases
  • , 7,723 controls
]
 — South Asian — UKB —
PSS004475 — —
[
  • 1,146 cases
  • , 66,279 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS009347 — — 19,615 individuals — European UK (+ Ireland) UKB —
PSS008449 — — 1,183 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS000970 — Median = 400.0 days 1,584 individuals — European — GNEHGI2020Q2 —
PSS009651 — Median = 10.88 years 345,672 individuals,
48.0 % Male samples
 Mean = 56.53 years
Sd = 8.06 years		 European — UKB —
PSS009819 — — 6,503 individuals — African unspecified — UKB —
PSS009820 — — 922 individuals — East Asian — UKB —
PSS009821 — — 43,505 individuals — European Non-British European UKB —
PSS009822 — — 8,098 individuals — South Asian — UKB —
PSS010186 Plaque psoriasis patients with at least one exposure to biologic therapy. Cases developed one or more paradoxical eczema adverse events during treatment with one of the following biologics: TNF-alpha inhibitors (adalimumab; etanercept; certolizumab; infliximab), IL-17 inhibitors (brodalumab; secukinumab; ixekizumab), IL-12/23 inhibitors (ustekinumab) and IL-23p19 inhibitors (guselkumab; risankizumab; tildrakizumab). Controls has no recorded eczema events during biologic therapy. Participants may have been exposed to more than one biologic. —
[
  • 88 cases
  • , 3,124 controls
]
 — European — BSTOP —
PSS010968 — —
[
  • 3,750 cases
  • , 952 controls
]
 — European — NR GCAT
PSS010969 — —
[
  • 243 cases
  • , 4,702 controls
]
 — European — NR GCAT
PSS009121 — — 4,059 individuals — European Poland (NE Europe) UKB —
PSS009939 — — 39,444 individuals — European
(Finnish)		 — FinnGen —
PSS008229 — — 6,161 individuals — South Asian India (South Asia) UKB —
PSS010974 — —
[
  • 34 cases
  • , 4,945 controls
]
 — European — NR GCAT
PSS004384 — —
[
  • 157 cases
  • , 6,340 controls
]
 — African unspecified — UKB —
PSS004385 — —
[
  • 66 cases
  • , 1,638 controls
]
 — East Asian — UKB —
PSS010977 — — 4,987 individuals — European — NR GCAT
PSS004386 — —
[
  • 873 cases
  • , 24,032 controls
]
 — European non-white British ancestry UKB —
PSS004387 — —
[
  • 243 cases
  • , 7,588 controls
]
 — South Asian — UKB —
PSS004388 — —
[
  • 2,514 cases
  • , 64,911 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS011376 — Median = 12.0 years 337,910 individuals,
45.6 % Male samples
 Mean = 57.1 years
Sd = 8.0 years		 European — UKB —
PSS004153 — —
[
  • 343 cases
  • , 6,154 controls
]
 — African unspecified — UKB —
PSS004154 — —
[
  • 143 cases
  • , 1,561 controls
]
 — East Asian — UKB —
PSS004155 — —
[
  • 2,053 cases
  • , 22,852 controls
]
 — European non-white British ancestry UKB —