Polygenic Score (PGS) ID: PGS000018

Predicted Trait
Reported Trait Coronary artery disease
Mapped Trait(s) coronary artery disease (EFO_0001645)
Released in PGS Catalog: Oct. 14, 2019
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name metaGRS_CAD
Development Method
Name metaGRS
Parameters metaGRS log(HR) mixing weights: GRS46K=0.1278, FDR202=0.2359 and 1000Genomes=0.2400
Variants
Original Genome Build hg19
Number of Variants 1,745,179
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000007
Citation (link to publication) Inouye M et al. J Am Coll Cardiol (2018)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 50.9%
  • European
  • South Asian
European: 37%
South Asian: 6.7%
East Asian: 3%
Hispanic or Latin American: 1.1%
African: 0.8%
Greater Middle Eastern: 0.6%
382,026 individuals (100%)
Score Development/Training
Multi-ancestry (including European): 100%
  • European
  • Not Reported
3,000 individuals (100%)
PGS Evaluation
European: 67.7%
African: 9.7%
Hispanic or Latin American: 9.7%
Multi-ancestry (including European): 9.7%
  • European
  • Not Reported
  • African
  • Additional Asian Ancestries
  • South Asian
  • East Asian
Greater Middle Eastern: 3.2%
31 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST003116
Europe PMC: 26343387
 2,268 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) 40 cohorts
  • ADVANCE
  • ,AGES
  • ,AIDHS
  • ,ARIC
  • ,BAS
  • ,BioMe
  • ,CARDIOGENICS
  • ,CAS
  • ,CCGB
  • ,COROGENE
  • ,DUKE_2
  • ,EGCUT
  • ,FGENTCARD
  • ,FHS
  • ,FINRISK
  • ,FamHS
  • ,GENRIC
  • ,GerMIFS
  • ,GoDARTS
  • ,HPS
  • ,HSDS
  • ,HSIEA
  • ,ITH
  • ,LIFE-HEART
  • ,LOLIPOP
  • ,LURIC
  • ,MAYO-VDB
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PIVUS
  • ,PROCARDIS
  • ,PROMIS
  • ,PROSPER
  • ,PennCATH
  • ,RS
  • ,TwinGene
  • ,ULSAM
  • ,WGHS
  • ,WTCCC
Europe PMC: 23202125
[
  • 63,746 cases
  • , 130,681 controls
]
 European, South Asian 34 cohorts
  • ADVANCE
  • ,AMC-PAS
  • ,Angio-Lueb
  • ,CARDIOGENICS
  • ,COROGENE
  • ,DILGOM
  • ,Duke
  • ,EGCUT
  • ,EMIL
  • ,EPIC
  • ,FGENTCARD
  • ,FINCAVAS
  • ,FRISCII
  • ,GENRIC
  • ,GLACIER
  • ,GoDARTS
  • ,HPS
  • ,HSIEA
  • ,ITH
  • ,KORA
  • ,LOLIPOP
  • ,LURIC
  • ,METSIM
  • ,MORGAM
  • ,OHGS
  • ,PIVUS
  • ,PMB
  • ,POPGEN
  • ,PROCARDIS
  • ,PROMIS
  • ,SCARFSHEEP
  • ,STR
  • ,ULSAM
  • ,WTCCC
GWAS Catalog: GCST003116
Europe PMC: 26343387
 3,139 individuals African American or Afro-Caribbean 41 cohorts
  • ADVANCE
  • ,AGES
  • ,AIDHS
  • ,ARIC
  • ,BAS
  • ,BioMe
  • ,CARDIOGENICS
  • ,CAS
  • ,CCGB
  • ,COROGENE
  • ,DUKE_2
  • ,EGCUT
  • ,FGENTCARD
  • ,FHS
  • ,FINRISK
  • ,FamHS
  • ,GENRIC
  • ,GerMIFS
  • ,GoDARTS
  • ,HPS
  • ,HSDS
  • ,HSIEA
  • ,ITH
  • ,LIFE-HEART
  • ,LOLIPOP
  • ,LURIC
  • ,MAYO-VDB
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PIVUS
  • ,PROCARDIS
  • ,PROMIS
  • ,PROSPER
  • ,PennCATH
  • ,RS
  • ,SDS
  • ,TwinGene
  • ,ULSAM
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST003116
Europe PMC: 26343387
 4,095 individuals Hispanic or Latin American 41 cohorts
  • ADVANCE
  • ,AGES
  • ,AIDHS
  • ,ARIC
  • ,BAS
  • ,BioMe
  • ,CARDIOGENICS
  • ,CAS
  • ,CCGB
  • ,COROGENE
  • ,DUKE_2
  • ,EGCUT
  • ,FGENTCARD
  • ,FHS
  • ,FINRISK
  • ,FamHS
  • ,GENRIC
  • ,GerMIFS
  • ,GoDARTS
  • ,HPS
  • ,HSDS
  • ,HSIEA
  • ,ITH
  • ,LIFE-HEART
  • ,LOLIPOP
  • ,LURIC
  • ,MAYO-VDB
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PIVUS
  • ,PROCARDIS
  • ,PROMIS
  • ,PROSPER
  • ,PennCATH
  • ,RS
  • ,SDS
  • ,TwinGene
  • ,ULSAM
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST003116
Europe PMC: 26343387
 11,323 individuals East Asian 41 cohorts
  • ADVANCE
  • ,AGES
  • ,AIDHS
  • ,ARIC
  • ,BAS
  • ,BioMe
  • ,CARDIOGENICS
  • ,CAS
  • ,CCGB
  • ,COROGENE
  • ,DUKE_2
  • ,EGCUT
  • ,FGENTCARD
  • ,FHS
  • ,FINRISK
  • ,FamHS
  • ,GENRIC
  • ,GerMIFS
  • ,GoDARTS
  • ,HPS
  • ,HSDS
  • ,HSIEA
  • ,ITH
  • ,LIFE-HEART
  • ,LOLIPOP
  • ,LURIC
  • ,MAYO-VDB
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PIVUS
  • ,PROCARDIS
  • ,PROMIS
  • ,PROSPER
  • ,PennCATH
  • ,RS
  • ,SDS
  • ,TwinGene
  • ,ULSAM
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST003116
Europe PMC: 26343387
 25,557 individuals South Asian 41 cohorts
  • ADVANCE
  • ,AGES
  • ,AIDHS
  • ,ARIC
  • ,BAS
  • ,BioMe
  • ,CARDIOGENICS
  • ,CAS
  • ,CCGB
  • ,COROGENE
  • ,DUKE_2
  • ,EGCUT
  • ,FGENTCARD
  • ,FHS
  • ,FINRISK
  • ,FamHS
  • ,GENRIC
  • ,GerMIFS
  • ,GoDARTS
  • ,HPS
  • ,HSDS
  • ,HSIEA
  • ,ITH
  • ,LIFE-HEART
  • ,LOLIPOP
  • ,LURIC
  • ,MAYO-VDB
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PIVUS
  • ,PROCARDIS
  • ,PROMIS
  • ,PROSPER
  • ,PennCATH
  • ,RS
  • ,SDS
  • ,TwinGene
  • ,ULSAM
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST003116
Europe PMC: 26343387
 141,217 individuals European 41 cohorts
  • ADVANCE
  • ,AGES
  • ,AIDHS
  • ,ARIC
  • ,BAS
  • ,BioMe
  • ,CARDIOGENICS
  • ,CAS
  • ,CCGB
  • ,COROGENE
  • ,DUKE_2
  • ,EGCUT
  • ,FGENTCARD
  • ,FHS
  • ,FINRISK
  • ,FamHS
  • ,GENRIC
  • ,GerMIFS
  • ,GoDARTS
  • ,HPS
  • ,HSDS
  • ,HSIEA
  • ,ITH
  • ,LIFE-HEART
  • ,LOLIPOP
  • ,LURIC
  • ,MAYO-VDB
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PIVUS
  • ,PROCARDIS
  • ,PROMIS
  • ,PROSPER
  • ,PennCATH
  • ,RS
  • ,SDS
  • ,TwinGene
  • ,ULSAM
  • ,WGHS
  • ,WTCCC
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 1,000 cases
  • , 2,000 controls
]
 European, NR UKB CAD was defined as fatal or nonfatal myocardial infarction (MI) cases, percutaneous transluminal coronary angioplasty (PTCA), or coronary artery bypass grafting (CABG). Prevalent versus incident status was relative to the UKB enrollment assessment. In UKB self-reported data, cases were defined as having had a heart attack diagnosed by a doctor (data field #6150); “non-cancer illnesses that self-reported as heart attack” (data field #20002); or self-reported operation including PTCA, CABG, or triple heart bypass (data field #20004). In HES hospital episodes data and death registry data, MI was defined as hospital admission or cause of death due to ICD-9 410 to 412, or ICD-10 I21 to I24 or I25.2; CABG and PTCA were defined as hospital admission OPCS-4 K40 to K46, K49, K50.1,or K75. — — ~95% European ancestry samples, <5% non-European ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000027 PSS000018|
Multi-ancestry (including European)|
482,629 individuals
 PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
 Reported Trait: Incident coronary artery disease HR: 1.706 [1.682, 1.73] AUROC: 0.79
C-index: 0.623 [0.615, 0.631]		 AUPRC: 0.161 sex, genetic PCs (1-10), genotyping array age-as-time-scale Cox regression
PPM000597 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.53 [1.23, 1.9] C-index: 0.683 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000594 PSS000332|
African Ancestry|
7,070 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.27 [1.13, 1.43] C-index: 0.663 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000591 PSS000334|
European Ancestry|
39,758 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.53 [1.46, 1.6] C-index: 0.719 — sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000616 PSS000334|
European Ancestry|
39,758 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.49 [1.43, 1.56] C-index: 0.75 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000620 PSS000332|
African Ancestry|
7,070 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.25 [1.12, 1.41] C-index: 0.723 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000624 PSS000336|
Hispanic or Latin American Ancestry|
2,194 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.5 [1.21, 1.87] C-index: 0.725 — sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM001666 PSS000868|
European Ancestry|
3,087 individuals
 PGP000137 |
Ritchie SC et al. Nat Metab (2021)
|Ext.		 Reported Trait: Incident myocardial infarction HR: 2.89 [1.66, 5.04] — — age, sex, 10 genetic PCs —
PPM001845 PSS000929|
European Ancestry|
5,581 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
|Ext.		 Reported Trait: Coronary artery disease — AUROC: 0.5015 [0.483, 0.514] Area under the Precision-Recall curve (AUPRC): 0.5205 [0.5201, 0.521] — —
PPM001846 PSS000930|
European Ancestry|
27,048 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
|Ext.		 Reported Trait: Coronary artery disease — AUROC: 0.6597 [0.6405, 0.6789] Area under the Precision-Recall curve (AUPRC): 0.0673 [0.0668, 0.0679] — —
PPM000034 PSS000021|
European Ancestry|
1,964 individuals
 PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.		 Reported Trait: Coronary artery disease (prevalent) OR: 1.74 [1.57, 1.93] AUROC: 0.72 [0.7, 0.75] — age, sex, first four genetic PCs —
PPM000035 PSS000022|
European Ancestry|
3,309 individuals
 PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.		 Reported Trait: Coronary artery disease (prevalent) OR: 1.6 [1.43, 1.8] AUROC: 0.89 [0.88, 0.91] — age, sex, first four genetic PCs —
PPM000036 PSS000019|
European Ancestry|
5,762 individuals
 PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.		 Reported Trait: Coronary artery disease (prevalent) OR: 1.75 [1.49, 2.05] AUROC: 0.84 [0.81, 0.87] — age, sex, first four genetic PCs, cohort recruitment centre —
PPM000037 PSS000020|
European Ancestry|
3,195 individuals
 PGP000008 |
Wünnemann F et al. Circ Genom Precis Med (2019)
|Ext.		 Reported Trait: Reccurent coronary artery disease events OR: 1.17 [1.08, 1.26] — — age, sex, first four genetic PCs —
PPM000518 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Plaque vulnerability score β: 0.07 [0.003, 0.137] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000517 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Microvessels β: 0.037 [-0.006, 0.08] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000516 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Number of smoooth muscle cells β: -0.004 [-0.038, 0.031] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000515 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Number of macrophages β: 0.01 [-0.015, 0.036] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000514 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Moderate/heavy macrophages OR: 1.103 [0.983, 1.237] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000513 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Moderate/heavy smooth muscle cells OR: 1.004 [0.88, 1.145] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000512 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Presence of IPH OR: 1.126 [0.999, 1.27] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000511 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Presence of lipid core >10% OR: 1.171 [1.026, 1.337] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000510 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Moderate/heavy collagen OR: 1.064 [0.919, 1.231] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000509 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Moderate/heavy calficiations OR: 0.94 [0.826, 1.07] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000508 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Plaque vulnerability score OR: 0.198 [0.003, 0.364] — — Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000507 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Microvessels — — Beta (top 20% vs. rest): 0.072 [-0.037, 0.182] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000506 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Number of smoooth muscle cells — — Beta (top 20% vs. rest): -0.056 [-0.143, 0.031] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000505 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Number of macrophages — — Beta (top 20% vs. rest): 0.55 [-0.012, 0.121] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000504 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Moderate/heavy macrophages — — Odds Ratio (OR; top 20% vs. rest): 1.49 [1.118, 1.986] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000503 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Moderate/heavy smooth muscle cells — — Odds Ratio (OR; top 20% vs. rest): 0.908 [0.652, 1.265] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000502 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Presence of IPH — — Odds Ratio (OR; top 20% vs. rest): 1.112 [0.821, 1.506] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000501 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Presence of lipid core >10% — — Odds Ratio (OR; top 20% vs. rest): 1.591 [1.105, 2.291] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000500 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Moderate/heavy collagen — — Odds Ratio (OR; top 20% vs. rest): 1.091 [0.755, 1.577] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000499 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Moderate/heavy calficiations — — Odds Ratio (OR; top 20% vs. rest): 1.001 [0.754, 1.33] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs —
PPM000498 PSS000287|
European Ancestry|
1,319 individuals
 PGP000077 |
Timmerman N et al. Atherosclerosis (2020)
|Ext.		 Reported Trait: Secondary cardiovascular events HR: 1.15 [1.02, 1.29] — — Age, sex, diabetes, BMI, smoking, hypercholesterolemia, array, 4 genetics PCs —
PPM000603 PSS000331|
African Ancestry|
7,597 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.4 [1.3, 1.52] AUROC: 0.775 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000600 PSS000333|
European Ancestry|
45,645 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.73 [1.68, 1.78] AUROC: 0.772 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM000606 PSS000335|
Hispanic or Latin American Ancestry|
2,493 individuals
 PGP000083 |
Dikilitas O et al. Am J Hum Genet (2020)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.93 [1.67, 2.22] AUROC: 0.794 — age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components —
PPM001847 PSS000931|
European Ancestry|
431,814 individuals
 PGP000152 |
Gola D et al. Circ Genom Precis Med (2020)
|Ext.		 Reported Trait: Coronary artery disease — AUROC: 0.6377 [0.6339, 0.6416] Area under the Precision-Recall curve (AUPRC): 0.0832 [0.083, 0.0835] — May be an overlap between score development and testing sample
PPM005152 PSS003597|
Multi-ancestry (including European)|
12,413 individuals
 PGP000248 |
Liou L et al. Breast Cancer Res (2021)
|Ext.		 Reported Trait: Incident coronary artery disease survival in individuals with breast cancer HR: 1.36 [1.23, 1.5] — — Age SNPs with imputation quality scores of less than 0.3 and ambiguous strand SNPs (A/T and G/C pairs) were excluded from PGS000018.
PPM005153 PSS003596|
European Ancestry|
8,946 individuals
 PGP000248 |
Liou L et al. Breast Cancer Res (2021)
|Ext.		 Reported Trait: Incident coronary artery disease in individuals with breast cancer HR: 1.36 [1.23, 1.51] — — Age at diagnosis, genotype array, PCs(1-8) SNPs with imputation quality scores of less than 0.3 and ambiguous strand SNPs (A/T and G/C pairs) were excluded from PGS000018.
PPM005154 PSS003596|
European Ancestry|
8,946 individuals
 PGP000248 |
Liou L et al. Breast Cancer Res (2021)
|Ext.		 Reported Trait: Incident coronary artery disease in individuals with breast cancer HR: 1.34 [1.21, 1.49] — — Age at diagnosis, genotype array, PCs(1-8), body mass index, smoking SNPs with imputation quality scores of less than 0.3 and ambiguous strand SNPs (A/T and G/C pairs) were excluded from PGS000018.
PPM005155 PSS003596|
European Ancestry|
8,946 individuals
 PGP000248 |
Liou L et al. Breast Cancer Res (2021)
|Ext.		 Reported Trait: Incident coronary artery disease in individuals with breast cancer HR: 1.34 [1.21, 1.48] — — Age at diagnosis, genotype array, PCs(1-8), body mass index, smoking, sociodemographic variables SNPs with imputation quality scores of less than 0.3 and ambiguous strand SNPs (A/T and G/C pairs) were excluded from PGS000018.
PPM005156 PSS003596|
European Ancestry|
8,946 individuals
 PGP000248 |
Liou L et al. Breast Cancer Res (2021)
|Ext.		 Reported Trait: Incident coronary artery disease in individuals with breast cancer HR: 1.33 [1.2, 1.48] — — Age at diagnosis, genotype array, PCs(1-8), body mass index, smoking, sociodemographic variables, medical variables SNPs with imputation quality scores of less than 0.3 and ambiguous strand SNPs (A/T and G/C pairs) were excluded from PGS000018.
PPM005157 PSS003596|
European Ancestry|
8,946 individuals
 PGP000248 |
Liou L et al. Breast Cancer Res (2021)
|Ext.		 Reported Trait: Incident coronary artery disease in individuals with breast cancer HR: 1.33 [1.2, 1.47] — — Age at diagnosis, genotype array, PCs(1-8), body mass index, smoking, sociodemographic variables, medical variables, oncotherapies SNPs with imputation quality scores of less than 0.3 and ambiguous strand SNPs (A/T and G/C pairs) were excluded from PGS000018.
PPM015480 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Uterine cancer death HR: 0.68 [0.46, 1.0] — — — —
PPM015451 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Self-reported hypertension OR: 1.2 [1.16, 1.24] — — — —
PPM015478 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Brain cancer death HR: 0.71 [0.52, 0.97] — — — —
PPM015479 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Pneumonia death HR: 1.14 [1.0, 1.3] — — — —
PPM017200 PSS010162|
European Ancestry|
292,438 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Acute myocardial infarction or revascularization OR: 1.54 [1.52, 1.56] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017201 PSS010161|
Hispanic or Latin American Ancestry|
30,648 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Acute myocardial infarction or revascularization OR: 1.62 [1.54, 1.71] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017202 PSS010160|
African Ancestry|
76,709 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Acute myocardial infarction or revascularization OR: 1.2 [1.17, 1.2] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017203 PSS010162|
European Ancestry|
292,438 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.38 [1.36, 1.39] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017204 PSS010161|
Hispanic or Latin American Ancestry|
30,648 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.39 [1.34, 1.43] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017205 PSS010160|
African Ancestry|
76,709 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.12 [1.1, 1.14] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017206 PSS010162|
European Ancestry|
292,438 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Acute myocardial infarction or revascularization in incident coronary artery disease OR: 1.47 [1.44, 1.5] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017207 PSS010161|
Hispanic or Latin American Ancestry|
30,648 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Acute myocardial infarction or revascularization in incident coronary artery disease OR: 1.5 [1.38, 1.63] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017208 PSS010160|
African Ancestry|
76,709 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Acute myocardial infarction or revascularization in incident coronary artery disease OR: 1.17 [1.12, 1.22] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017209 PSS010162|
European Ancestry|
292,438 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Incident coronary artery disease OR: 1.27 [1.25, 1.29] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017210 PSS010161|
Hispanic or Latin American Ancestry|
30,648 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Incident coronary artery disease OR: 1.24 [1.17, 1.32] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017211 PSS010160|
African Ancestry|
76,709 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Incident coronary artery disease OR: 1.1 [1.07, 1.14] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM015476 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Cerebrovascular death HR: 1.11 [1.03, 1.2] — — — —
PPM015477 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Dementia death HR: 1.11 [1.02, 1.21] — — — —
PPM015454 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Self-reported family history of myocardial infarction OR: 1.16 [1.13, 1.2] — — — —
PPM015455 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Self-reported family history of stroke OR: 1.07 [1.04, 1.11] — — — —
PPM015456 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Self-reported history of breast cancer OR: 0.81 [0.69, 0.95] — — — —
PPM015457 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Self-reported history of non-melanoma skin cancer OR: 0.93 [0.89, 0.98] — — — —
PPM015458 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Self-reported family history of colon cancer OR: 0.95 [0.91, 0.99] — — — —
PPM015459 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Self-reported history of colonoscopy OR: 0.96 [0.93, 0.99] — — — —
PPM015461 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident PTCA OR: 1.53 [1.43, 1.63] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015462 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident myocardial infarction OR: 1.41 [1.32, 1.5] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015463 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident coronary heart disease OR: 1.31 [1.23, 1.38] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015464 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident CABG OR: 1.53 [1.39, 1.7] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015465 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident all angina OR: 1.38 [1.26, 1.51] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015466 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident ischemic stroke OR: 1.11 [1.04, 1.19] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015467 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident all stroke OR: 1.09 [1.03, 1.16] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015468 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident TIA OR: 1.21 [1.04, 1.41] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015469 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident peripheral artery disease OR: 1.16 [1.01, 1.32] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015470 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident carotid disease OR: 1.14 [1.0, 1.3] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015471 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident any cancer OR: 0.96 [0.93, 0.99] — — Smoking status, alcohol consumption, weekly physical activity, dietary health measured by the alternative healthy eating index, and BMI —
PPM015472 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident lung cancer OR: 0.91 [0.83, 0.99] — — Smoking status, alcohol consumption, weekly physical activity, dietary health measured by the alternative healthy eating index, and BMI —
PPM015473 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident breast cancer OR: 0.96 [0.92, 1.0] — — Smoking status, alcohol consumption, weekly physical activity, dietary health measured by the alternative healthy eating index, and BMI —
PPM015474 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Coronary heart disease death HR: 1.29 [1.16, 1.43] — — — —
PPM015475 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Death of unknown cause HR: 1.28 [1.07, 1.54] — — — —
PPM015452 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Self-reported hypercholesterolemia OR: 1.17 [1.12, 1.23] — — — —
PPM015453 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Self-reported rheumatoid arthritis OR: 1.11 [1.03, 1.19] — — — —
PPM015460 PSS009958|
European Ancestry|
21,863 individuals
 PGP000372 |
Clarke SL et al. Commun Med (Lond) (2022)
|Ext.		 Reported Trait: Incident coronary revascularization OR: 1.54 [1.45, 1.63] — — Smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol —
PPM015502 PSS009965|
European Ancestry|
836 individuals
 PGP000378 |
Schoepf IC et al. Clin Infect Dis (2021)
|Ext.		 Reported Trait: Coronary artery disease — — Odds Ratio (OR, fifth vs. first quintile): 3.17 [1.74, 5.79] Clinical risk factors —
PPM015504 PSS009965|
European Ancestry|
836 individuals
 PGP000378 |
Schoepf IC et al. Clin Infect Dis (2021)
|Ext.		 Reported Trait: Coronary artery disease — — Odds Ratio (OR, fifth vs. first quintile): 3.67 [2.0, 6.73] Clinical risk factors, PRS_longetivity Combined as metaPRS
PPM015571 PSS009986|
Greater Middle Eastern Ancestry|
7,023 individuals
 PGP000386 |
Saad M et al. Circ Genom Precis Med (2022)
|Ext.		 Reported Trait: Coronary heart disease OR: 1.54 [1.43, 1.66] AUROC: 0.686 [0.667, 0.704] — — —
PPM017084 PSS010120|
European Ancestry|
4,218 individuals
 PGP000433 |
de La Harpe R et al. Eur J Prev Cardiol (2023)
|Ext.		 Reported Trait: Atherosclerotic cardiovascular disease (incident and prevalent) OR: 1.36 [1.21, 1.52] AUROC: 0.772 [0.748, 0.796] — sex, age —
PPM017085 PSS010122|
European Ancestry|
4,218 individuals
 PGP000433 |
de La Harpe R et al. Eur J Prev Cardiol (2023)
|Ext.		 Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.63 [1.45, 1.83] AUROC: 0.793 [0.77, 0.816] — sex, age —
PPM017086 PSS010119|
European Ancestry|
3,383 individuals
 PGP000433 |
de La Harpe R et al. Eur J Prev Cardiol (2023)
|Ext.		 Reported Trait: Incident atherosclerotic cardiovascular disease HR: 1.31 [1.13, 1.51] AUROC: 0.769 [0.734, 0.804]
C-index: 0.779 [0.746, 0.811]		 — sex, age, 10 principal components —
PPM017087 PSS010121|
European Ancestry|
3,383 individuals
 PGP000433 |
de La Harpe R et al. Eur J Prev Cardiol (2023)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.62 [1.43, 1.84] AUROC: 0.784 [0.757, 0.811]
C-index: 0.79 [0.764, 0.816]		 — sex, age, 10 principal components —
PPM018467 PSS010981|
European Ancestry|
3,459 individuals
 PGP000468 |
Hodel F et al. Elife (2023)
|Ext.		 Reported Trait: Coronary heart disease HR: 1.32 [1.16, 1.51] — — — —
PPM021306 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Incident cardiovascular disease outcome HR: 1.31 [1.27, 1.34] — — Age at baseline, smoking status, history of diabetes, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol levels, stratified by study centre, sex —
PPM021307 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.49 [1.44, 1.54] — — Age at baseline, smoking status, history of diabetes, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol levels, stratified by study centre, sex —
PPM021308 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Incident coronary heart disease HR: 1.57 [1.51, 1.62] — — Age at baseline, stratified by study centre, sex —
PPM021309 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Incident stroke HR: 1.09 [1.04, 1.13] — — Age at baseline, smoking status, history of diabetes, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol levels, stratified by study centre, sex —
PPM021310 PSS011681|
European Ancestry|
306,654 individuals
 PGP000628 |
Sun L et al. PLoS Med (2021)
|Ext.		 Reported Trait: Combination of incident coronary heart disease, stroke and cardiac revascularisation procedures HR: 1.39 [1.36, 1.42] — — Age at baseline, smoking status, history of diabetes, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol levels, stratified by study centre, sex —
PPM021742 PSS011775|
Multi-ancestry (including European)|
199,997 individuals
 PGP000669 |
Saadatagah S et al. JACC Adv (2023)
|Ext.		 Reported Trait: Coronary heart disease onset > 70 years — — Odds ratio (OR, top 5th percentile vs 20-80th percentile): 1.91 [1.68, 2.17] Sex, 4 PCs —
PPM021743 PSS011775|
Multi-ancestry (including European)|
199,997 individuals
 PGP000669 |
Saadatagah S et al. JACC Adv (2023)
|Ext.		 Reported Trait: Coronary heart disease onset < 50 years — — Odds ratio (OR, top 5th percentile vs 20-80th percentile): 3.25 [2.73, 3.85] Sex, 4 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS003596 All individuals had breast cancer. Cases were individuals who suffered incident coronary artery disease (CAD) events. Incident CAD events were defined as a composite endpoint of unstable angina, myocardial infarction, or death due to complications following myocardial infarction according to the International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10 codes): I21, I22, I23, I25 and I25. —
[
  • 432 cases
  • , 8,514 controls
]
,
0.0 % Male samples
 — European — SEARCH —
PSS003597 All individuals had breast cancer. Cases were individuals who suffered incident coronary artery disease (CAD) events. Incident CAD events were defined as a composite endpoint of unstable angina, myocardial infarction, or death due to complications following myocardial infarction according to the International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10 codes): I21, I22, I23, I25 and I25. Median = 10.3 years
[
  • 750 cases
  • , 11,663 controls
]
,
0.0 % Male samples
 — European, African unspecified, Asian unspecified, Not reported European = 11,995, African unspecified = 1, Asian unspecified = 2, Not reported = 413 SEARCH —
PSS011775 — — 190,489 individuals — European — UKB —
PSS011775 — — 4,412 individuals — South Asian — UKB —
PSS011775 — — 3,795 individuals — African unspecified — UKB —
PSS011775 — — 1,230 individuals — East Asian — UKB —
PSS011775 — — 71 individuals — Not reported — UKB —
PSS009958 — — 21,863 individuals,
0.0 % Male samples
 Mean = 65.3 years European
(Non-Hispanic White)		 — WHI —
PSS009965 CAD events were defined according to the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) study and the MONICA Project of the World Health Organization, as reported elsewhere —
[
  • 269 cases
  • , 567 controls
]
 — European — SHCS —
PSS010119 Atherosclerotic cardiovacular disease (ASCVD), comprising non-fatal acute myocardial infarction, death of cardiovascular origin (comprising sudden death, ischemic death) and fatal and non-fatal ischaemic stroke (including transient ischaemic attack) using relevant medical records and ICD codes. All events were adjudicated by two expert. More details in PMID: 33838036 Median = [10.7, 14.6] years
[
  • 190 cases
  • , 3,193 controls
]
,
45.0 % Male samples
 Mean = 52.3 years European — CoLaus right censored was death or latest evidence of good health, participant with statine therapy at baseline were excluded
PSS010120 Atherosclerotic cardiovacular disease (ASCVD), comprising non-fatal acute myocardial infarction, death of cardiovascular origin (comprising sudden death, ischemic death) and fatal and non-fatal ischaemic stroke (including transient ischaemic attack) using relevant medical records and ICD codes. All events were adjudicated by two expert. More details in PMID: 33838036 Median = [10.6, 14.6] years
[
  • 363 cases
  • , 3,855 controls
]
,
47.0 % Male samples
 Mean = 53.4 years European — CoLaus right censored was death or latest evidence of good health
PSS010121 Coronary artery disease (CAD), ccomprising either non-fatal myocardial infarction, death from coronary heart disease or symptomatic stable angina followed by a revascularization procedure, either by percutaneous coronary intervention (PCI), or by coronary artery bypass grafting (CABG) using relevant medical records and ICD codes. All events were adjudicated by two expert. More details in PMID: 33838036 Median = [10.7, 14.6] years
[
  • 195 cases
  • , 3,188 controls
]
,
45.0 % Male samples
 Mean = 52.3 years European — CoLaus right censored was death or latest evidence of good health, participant with statine therapy at baseline were excluded
PSS010122 Coronary artery disease (CAD), ccomprising either non-fatal myocardial infarction, death from coronary heart disease or symptomatic stable angina followed by a revascularization procedure, either by percutaneous coronary intervention (PCI), or by coronary artery bypass grafting (CABG) using relevant medical records and ICD codes. All events were adjudicated by two expert. More details in PMID: 33838036 Median = [10.6, 14.6] years
[
  • 388 cases
  • , 3,830 controls
]
,
47.0 % Male samples
 Mean = 53.4 years European — CoLaus right censored was death or latest evidence of good health
PSS000018 CAD was defined as fatal or nonfatal myocardial infarction (MI) cases, percutaneous transluminal coronary angioplasty (PTCA), or coronary artery bypass grafting (CABG). Prevalent versus incident status was relative to the UKB enrollment assessment. In UKB self-reported data, cases were defined as having had a heart attack diagnosed by a doctor (data field #6150); “non-cancer illnesses that self-reported as heart attack” (data field #20002); or self-reported operation including PTCA, CABG, or triple heart bypass (data field #20004). In HES hospital episodes data and death registry data, MI was defined as hospital admission or cause of death due to ICD-9 410 to 412, or ICD-10 I21 to I24 or I25.2; CABG and PTCA were defined as hospital admission OPCS-4 K40 to K46, K49, K50.1,or K75. —
[
  • 22,242 cases
  • , 460,387 controls
]
,
45.6 % Male samples
 — European, NR ~95% European ancestry samples, <5% non-European ancestry UKB —
PSS000019 Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting). —
[
  • 173 cases
  • , 5,589 controls
]
,
41.29 % Male samples
 — European
(French Canadian)		 — CARTaGENE —
PSS000020 Recurrent CAD event during the follow- up period (median follow-up time =3.9 years [range =1.1–7), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting). —
[
  • 446 cases
  • , 416 controls
]
 — European
(French Canadian)		 — MHI Phase 1
PSS000020 Recurrent CAD event during the follow- up period (median follow-up time =3.9 years [range =1.1–7), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting). —
[
  • 937 cases
  • , 1,396 controls
]
 — European
(French Canadian)		 — MHI Phase 2
PSS000021 Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting). —
[
  • 974 cases
  • , 976 controls
]
,
72.7 % Male samples
 — European
(French Canadian)		 — MHI Phase 1
PSS000022 Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting). —
[
  • 2,492 cases
  • , 817 controls
]
,
72.38 % Male samples
 — European
(French Canadian)		 — MHI Phase 2
PSS000331 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 9.2 years
IQR = [5.5, 13.0] years
[
  • 838 cases
  • , 6,759 controls
]
,
31.0 % Male samples
 Mean = 43.6 years
Sd = 12.5 years		 African American or Afro-Caribbean — 7 cohorts
  • BioMe
  • ,BioVU
  • ,Columbia
  • ,KP
  • ,Nugene
  • ,PHB
  • ,eMERGE
 right censored at age 75 years or at the age of last observation (whichever was first)
PSS000332 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 9.2 years
IQR = [5.5, 13.0] years
[
  • 311 cases
  • , 6,759 controls
]
,
31.0 % Male samples
 Mean = 43.6 years
Sd = 12.5 years		 African American or Afro-Caribbean — 7 cohorts
  • BioMe
  • ,BioVU
  • ,Columbia
  • ,KP
  • ,Nugene
  • ,PHB
  • ,eMERGE
 right censored at age 75 years or at the age of last observation (whichever was first)
PSS000333 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 11.7 years
IQR = [6.0, 18.5] years
[
  • 8,108 cases
  • , 37,537 controls
]
,
44.6 % Male samples
 Mean = 49.0 years
Sd = 14.1 years		 European — 11 cohorts
  • BioMe
  • ,BioVU
  • ,CCHMC
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Marshfield
  • ,MyCode
  • ,Nugene
  • ,PHB
  • ,eMERGE
 right censored at age 75 years or at the age of last observation (whichever was first)
PSS000334 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 11.7 years
IQR = [6.0, 18.5] years
[
  • 2,221 cases
  • , 37,537 controls
]
,
44.6 % Male samples
 Mean = 49.0 years
Sd = 14.1 years		 European — 11 cohorts
  • BioMe
  • ,BioVU
  • ,CCHMC
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Marshfield
  • ,MyCode
  • ,Nugene
  • ,PHB
  • ,eMERGE
 right censored at age 75 years or at the age of last observation (whichever was first)
PSS000335 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 10.4 years
IQR = [5.7, 14.7] years
[
  • 419 cases
  • , 2,074 controls
]
,
36.2 % Male samples
 Mean = 41.1 years
Sd = 13.2 years		 Hispanic or Latin American — 8 cohorts
  • BioMe
  • ,BioVU
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Nugene
  • ,PHB
  • ,eMERGE
 right censored at age 75 years or at the age of last observation (whichever was first)
PSS000336 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 10.4 years
IQR = [5.7, 14.7] years
[
  • 120 cases
  • , 2,074 controls
]
,
36.2 % Male samples
 Mean = 41.1 years
Sd = 13.2 years		 Hispanic or Latin American — 8 cohorts
  • BioMe
  • ,BioVU
  • ,Columbia
  • ,KP
  • ,MAYO
  • ,Nugene
  • ,PHB
  • ,eMERGE
 right censored at age 75 years or at the age of last observation (whichever was first)
PSS000868 CALIBER rule-based phenotyping algorithms (https://www.caliberresearch.org/portal). ICD-10: I21-I23, I24.1, I25.2 Median = 6.9 years
[
  • 15 cases
  • , 3,072 controls
]
,
51.0 % Male samples
 Median = 44.0 years
IQR = [30.5, 54.7] years		 European — INTERVAL —
PSS009986 — —
[
  • 1,014 cases
  • , 6,009 controls
]
,
47.0 % Male samples
 — Greater Middle Eastern (Middle Eastern, North African or Persian)
(Qatari)		 — QBB —
PSS000287 (i) Secondary cardiovascular events (sCVE; incl myocardial infarction, stroke, ruptured abdominal aortic aneurysm, fatal cardiac failure, percuteneous of bypass surgery, leg amputation due to cardiovascular causes, cardiovascular death), (ii) atherosclerotic carotid plaque characteristics Mean = 3.0 years 1,319 individuals,
69.3 % Male samples
 Mean = 68.8 years
Sd = 9.3 years		 European
(Dutch)		 — AEGS1 —
PSS010981 — —
[
  • 210 cases
  • , 3,249 controls
]
,
46.0 % Male samples
 Mean = 52.83 years European — CoLaus —
PSS010160 — —
[
  • 17,202 cases
  • , 59,507 controls
]
 — African American or Afro-Caribbean — MVP —
PSS010161 — —
[
  • 6,378 cases
  • , 24,270 controls
]
 — Hispanic or Latin American — MVP —
PSS010162 — —
[
  • 95,151 cases
  • , 197,287 controls
]
 — European — MVP —
PSS011681 The primary outcome was a first-onset cardiovascular disease event, defined as the composite of CHD (i.e., myocardial infarction or fatal CHD) or any stroke. Secondary outcomes included each of CHD and stroke separately, and a combination of CHD, stroke, and cardiac revascularisation procedures (i.e., percutaneous transluminal cor- onary angioplasty [PTCA] and coronary artery bypass grafting [CABG]). 3333 Cases are CHD events and 2347 are stroke events Median = 8.1 years
[
  • 5,680 cases
  • , 300,974 controls
]
,
43.01 % Male samples
 Mean = 56.0 years
Sd = 8.0 years		 European — UKB —
PSS000929 For GERMIFSI and GERMIFSII, CAD was defined as Myocardinal infarction before the age of 60 and 1 or more 1st- degree relative with CAD. In GERMIFSIII CAD was defined as myocardial infarction between the ages of 26 and 74. In GERMIFSIV, cases were based on a CAD diagnosis before age 65 in men or age 70 in women. In Luric, cases were ascertained as >50% angiographic confirmation of vascular obstruction in 1 or more coronary vessel —
[
  • 2,919 cases
  • , 2,662 controls
]
 — European — GerMIFS, LURIC —
PSS000930 CAD ascertainment was based on myocardial infarction diagnosis or death cause using ICD-10 codes I21.X, I22.X, I23.X, I24.1, or I25.2 —
[
  • 840 cases
  • , 26,208 controls
]
 — European — EB —
PSS000931 CAD ascertainment was based on a composite of myocardial infarction or coronary revascularization. Myocardial infarction was based on ICD-9 codes 410.X, 411.X, 412.X, or 429.79, or ICD-10 codes I21.X, I22.X, I23.X, I24.1, or I25.2. Coronary revascularization was assessed based on OPCS-4 coded procedure for coronary artery bypass grafting (K40.1-40-4, K41.1-41.4, or K45.1-45.5), or coronary angioplasty with or without stenting (K49.1-49.2, K49.0-49.9, K50.2, K75.1-75.4, or K75.8-75.9) —
[
  • 21,025 cases
  • , 410,789 controls
]
 — European — UKB —